ID Q5CQN4_CRYPI Unreviewed; 569 AA.
AC Q5CQN4;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=APG7-like ubiquitin activating enzyme E1 {ECO:0000313|EMBL:EAK87707.1};
GN ORFNames=cgd4_40 {ECO:0000313|EMBL:EAK87707.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK87707.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK87707.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK87707.1}.
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DR EMBL; AAEE01000009; EAK87707.1; -; Genomic_DNA.
DR RefSeq; XP_625614.1; XM_625614.1.
DR AlphaFoldDB; Q5CQN4; -.
DR STRING; 353152.Q5CQN4; -.
DR EnsemblProtists; EAK87707; EAK87707; cgd4_40.
DR GeneID; 3372607; -.
DR KEGG; cpv:cgd4_40; -.
DR InParanoid; Q5CQN4; -.
DR OMA; LFRANND; -.
DR OrthoDB; 1128973at2759; -.
DR Proteomes; UP000006726; Chromosome 4.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR CDD; cd01486; Apg7; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF3; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006726}.
FT DOMAIN 236..483
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 569 AA; 64970 MW; B32F1AAB52BE1387 CRC64;
MSAIINFGNI DHGCDSYLES AVDNAMMWIN NSSNHEKYPF TFKLCIYFDF KTQIAYYSAF
FPNVNTNFNI KTDKQSELGI EIKSNLPEYS GSYIDLSSIN KNSNSLAVLK TLKDRVEGKI
GNFNDETSIE KKERFDCPWF FSTLLTIILF KDKYKNLLKT NEIIKLLKES GSNGNFKFDS
RSCFISNKHV KNVLAISDKE MKELQSEHIL PFDLKNYLSP HELQQRLSTM NIDLIKWRLI
PNFEQIHFKN LKFLIVGSGT LGCSVARNLI GWGIRNFKFI DHSKVSLNNP MRQCLFTLED
VKNKKNKAIA AVERLRYVCP DIHAEGIDFE IPILGDSTLS LEQFLKSVNE TKDNIIDSDV
VMLLTDNKES RWLPTVLIGL INRYYNRRRP ILCITVGLGF DSFIVVRNTF TETDYSSSGC
YFCGDFSINS KNNTLDIPVD QQCSVVRMGA SYFASSIAVE LIMNLSQHPL TWNAPHLSNE
SNKSDENKSL LGTTPQCIRG FLADFSFCTD PIQRNKCCIA CSDKLIDKIH KDEVNTLSEI
FINPRKVESI SGLTNFKSEM EKSITESYI
//
