ID Q5CU47_CRYPI Unreviewed; 1113 AA.
AC Q5CU47;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Insulinase like peptidase {ECO:0000313|EMBL:EAK89232.1};
DE Flags: Fragment;
GN ORFNames=cgd3_4240 {ECO:0000313|EMBL:EAK89232.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89232.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK89232.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK89232.1}.
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DR EMBL; AAEE01000004; EAK89232.1; -; Genomic_DNA.
DR RefSeq; XP_626967.1; XM_626967.1.
DR AlphaFoldDB; Q5CU47; -.
DR SMR; Q5CU47; -.
DR STRING; 353152.Q5CU47; -.
DR EnsemblProtists; EAK89232; EAK89232; cgd3_4240.
DR GeneID; 3374006; -.
DR KEGG; cpv:cgd3_4240; -.
DR InParanoid; Q5CU47; -.
DR OMA; VCISENA; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000006726; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 3.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 43..160
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 207..388
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK89232.1"
SQ SEQUENCE 1113 AA; 130236 MW; 4A3726C8CA7EACDB CRC64;
EKEMAIEENS SKYLEIVEDS EFIKPKESSF KCKFERLKTG LEVFLISSEK LTSTSVNLVV
KVGSANEGSE IDGLAHFLEH SVFLGTEKFP GQNEFGKFVR TYGGATNAST DILMTHYSFF
IPNQFLEPAL ERFCEFFKSP LFSEEYLQNE INIVENEFLS KTNNFYTLLE HVLKQIADET
HIYSKFFYGN SKTLKKIPEK NGISLRERTI RFFEEYYGSK NMVLFILSNI SIQELSKISY
KYFSNVRSCS RLSPKPESLS LFPELPYLGI SKKLVKIHLN INASQLMLMF SLPKKEYGLS
RIFSQYLSFF LCPKSGEGLL NDIIQKNLCH KISLNETYSQ LGFSYITFYL FLTKEGVFNI
REIILSLFSA FQIIKKTELI DEYIQRIANK DYLNFLKIED TLPSIQILEL LKVYYLTKGT
PEKLFSAIYS APQFSQQVFE DFMSYLNVEN MVTIIIDSNF DLGTLIKQEI IQKSNHKDYI
NKKYNFKDYI STIILSGRIR NIENKYLLSE KYFNTNYSIW DFTNKFLQSI SEIKIESGID
FSNVPLPMQT INMLESSKIK NSQIKTNLKP PLLFDIAYEF EKLKLSKEKD FVFSRNLKIS
SIWRGMFYMN VPKNIFPDSF FILRLLIPPL FGKKSFDQFS ESGFYIKDGY HSCVLIQLLS
ELIKLKINLN FERLSKEGIS AQIYPTFRSP FPNYAIGIEY YLYGKFESLS KFTDELSHTL
KNILKIKSEE FEFIKKNTIG KLLLIESQLL YKDLIGEAEH EVLNMGFINT KKFINLVNKV
KITEFIKFSD LFRRICIFEG IFVGDTPANI LKAVLDGFIL NLKNFKFSEI DKPLFYVKDN
PNNDNYLKPY YHKIFFTQNE NSNIYKRKKT QCNGFDMIDL FSIPPNKNKI YYLTKSIKSK
HNLIRLSVFF KRESPITFFK LQIINQVFFD ILFENVRQKK QIAYEFNSEV CEVSEKTLSY
SFVIQTDNHT ITSTIYTLLE CLKELSPTIL SEELFRVALL EKIECLEQMD SIFMEVNSFI
TNSFNRSFNY KLREEVLASL RSLDFIQFQS WFSNSLKNVP ILITVCISEN ASASDKKICK
KFVPPGFTKI KKPMELFEIY KVKSYYIQHR IFN
//
