ID Q5CUD1_CRYPI Unreviewed; 514 AA.
AC Q5CUD1;
DT 12-APR-2005, integrated into UniProtKB/TrEMBL.
DT 12-APR-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=phenylalanine--tRNA ligase {ECO:0000256|ARBA:ARBA00012814};
DE EC=6.1.1.20 {ECO:0000256|ARBA:ARBA00012814};
DE Flags: Fragment;
GN ORFNames=cgd3_3320 {ECO:0000313|EMBL:EAK89256.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89256.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK89256.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Phe-tRNA synthetase alpha subunit type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00006703}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK89256.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAEE01000004; EAK89256.1; -; Genomic_DNA.
DR RefSeq; XP_626883.1; XM_626883.1.
DR AlphaFoldDB; Q5CUD1; -.
DR STRING; 353152.Q5CUD1; -.
DR EnsemblProtists; EAK89256; EAK89256; cgd3_3320.
DR GeneID; 3373771; -.
DR KEGG; cpv:cgd3_3320; -.
DR InParanoid; Q5CUD1; -.
DR OMA; QIEGWVM; -.
DR OrthoDB; 4619at2759; -.
DR Proteomes; UP000006726; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004826; F:phenylalanine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006432; P:phenylalanyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00496; PheRS_alpha_core; 1.
DR Gene3D; 1.10.10.2320; -; 1.
DR Gene3D; 1.10.10.2330; -; 1.
DR Gene3D; 3.30.1370.240; -; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR004529; Phe-tRNA-synth_IIc_asu.
DR InterPro; IPR002319; Phenylalanyl-tRNA_Synthase.
DR InterPro; IPR040724; PheRS_DBD1.
DR InterPro; IPR040725; PheRS_DBD3.
DR NCBIfam; TIGR00468; pheS; 1.
DR PANTHER; PTHR11538:SF40; PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR11538; PHENYLALANYL-TRNA SYNTHETASE; 1.
DR Pfam; PF18552; PheRS_DBD1; 1.
DR Pfam; PF18553; PheRS_DBD3; 1.
DR Pfam; PF01409; tRNA-synt_2d; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000313|EMBL:EAK89256.1};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Ligase {ECO:0000313|EMBL:EAK89256.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726}.
FT DOMAIN 378..510
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAK89256.1"
SQ SEQUENCE 514 AA; 59095 MW; 97ABCF165B2E3DAF CRC64;
SCDQTMEVEP VTILEKLESL NCSLSSISIS EELKCEHERV IGVIKSLESR NIIKTQFISD
NMLSLTDEGK DYLLNGSPEY RLIKIILEKS DHKIKQDEAM TFLGGSIFKI GLSKCLQKKL
IKLNKELGLI EIPADSNMDL LNTDELGKNL LIVGVNGVKE SQLTKQDLQI IAELKKRKLA
ISQKISYFMI NKGEDFTVKL KPMITDLTQE MIMNSSWENN EFKPYNFNAK GKRLPRGNIH
PLTRTSRKFK RILSQMGFEE MPTNRWVESS FWNFDALFQP QKHPARDSHD TFFLETPSTF
RNEMELSNDH IDKVKKVHEI GGYGSIGLSY NWSIEEASKN LLRTHTTAVS VRMLYKLAQM
YLYNENGLSF DNFQRKAYFS IDRVFRNESI DATHLAEFHQ VEGLIVDKNL TLADLIGTLK
TFYEKIGISD LKFKPAFNPY TEPSMEIFGY HTTLKKWIEV GNSGLFRPEM LRPLGFPSDI
VVIAWGLSLE RPTMISYNIP NIRDLFSFKA KIFS
//
