ID   Q5CV27_CRYPI            Unreviewed;       683 AA.
AC   Q5CV27;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Cysteine-rich extracellular protein with a signal peptide and two apple domains {ECO:0000313|EMBL:EAK89209.1};
GN   ORFNames=cgd3_520 {ECO:0000313|EMBL:EAK89209.1};
OS   Cryptosporidium parvum (strain Iowa II).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89209.1, ECO:0000313|Proteomes:UP000006726};
RN   [1] {ECO:0000313|EMBL:EAK89209.1, ECO:0000313|Proteomes:UP000006726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX   PubMed=15044751; DOI=10.1126/science.1094786;
RA   Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA   Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA   Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA   Anantharaman V., Aravind L., Kapur V.;
RT   "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL   Science 304:441-445(2004).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAK89209.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAEE01000004; EAK89209.1; -; Genomic_DNA.
DR   RefSeq; XP_626637.1; XM_626637.1.
DR   AlphaFoldDB; Q5CV27; -.
DR   STRING; 353152.Q5CV27; -.
DR   EnsemblProtists; EAK89209; EAK89209; cgd3_520.
DR   GeneID; 3373798; -.
DR   KEGG; cpv:cgd3_520; -.
DR   VEuPathDB; CryptoDB:cgd3_520; -.
DR   InParanoid; Q5CV27; -.
DR   OMA; ANIFYKI; -.
DR   OrthoDB; 196167at2759; -.
DR   Proteomes; UP000006726; Chromosome 3.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR   InterPro; IPR000177; Apple.
DR   InterPro; IPR003609; Pan_app.
DR   Pfam; PF00024; PAN_1; 1.
DR   Pfam; PF14295; PAN_4; 1.
DR   SMART; SM00223; APPLE; 1.
DR   SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR   PROSITE; PS50948; PAN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006726}.
FT   DOMAIN          385..457
FT                   /note="Apple"
FT                   /evidence="ECO:0000259|PROSITE:PS50948"
SQ   SEQUENCE   683 AA;  75870 MW;  71CBF035B2FB9CE8 CRC64;
     MGKSWKQFKY GLLALAYILT IVKCQRKIPE YFNDGPFPSL SIPTSRFGNS TTFVADILDG
     ALSPFSYLKL AGISACGKLQ TGTPLPSVCY IDFELKCNNP SEGGLKIRGK PVVTHHGVID
     VTGGSFELNN GKSKAGGWGY GIFPYLGESS YFELTLVPVL NKKGEYVFEI YGVGYEKAHL
     TSESIGINCP FSIGEVIFKN VHWARTYIVG VNWIRNQLPF PNVIPKTKNK LVEMDAPFTP
     GSSWRLGGMF LSSLHVPVNP SIPIGNTDMR VILSCQKNNN NFLISLNSTG DITVSQLYTN
     YTNTQLFDQF KPNNEIFTGK YPHVMYNGLI VELVIARSLY AESGVIYLND LAIPKFFECR
     DNTIRVSVKH DTWAPLYTSN FTSNCHEYGS SFTGVNLFSI PTFLSPGQCQ NSCIQTSDCE
     FWTYNNKDNI CNGYSSEKYS FKRDSSTYSM ITGSVSCPCY SHNVNLVTPL LDGNDKVKVT
     NSAVSSPAEC QALVLENNGL GSYFVYNKEK KECYKQGVVK SNTVPIIDTN SVVGPSICYE
     YIYSNGVTRF SDKLQLIKSI KISTNSTDHH GEFCRSLCSM EEKCQIFELN NSYECMLYSI
     NDKRGLRPLF DIIENSWPTS GVILMGISTP LVVSYPNGNR EHILHAEVGS LSLDLTRSSD
     AFNSSLTTKQ LSILLAILLL LIL
//