ID   Q5CVP7_CRYPI            Unreviewed;       552 AA.
AC   Q5CVP7;
DT   12-APR-2005, integrated into UniProtKB/TrEMBL.
DT   12-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Importin alpha subunit {ECO:0000313|EMBL:EAK89707.1};
DE   Flags: Fragment;
GN   ORFNames=cgd8_3260 {ECO:0000313|EMBL:EAK89707.1};
OS   Cryptosporidium parvum (strain Iowa II).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX   NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89707.1, ECO:0000313|Proteomes:UP000006726};
RN   [1] {ECO:0000313|EMBL:EAK89707.1, ECO:0000313|Proteomes:UP000006726}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX   PubMed=15044751; DOI=10.1126/science.1094786;
RA   Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA   Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA   Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA   Anantharaman V., Aravind L., Kapur V.;
RT   "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL   Science 304:441-445(2004).
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAK89707.1}.
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DR   EMBL; AAEE01000003; EAK89707.1; -; Genomic_DNA.
DR   RefSeq; XP_627222.1; XM_627222.1.
DR   AlphaFoldDB; Q5CVP7; -.
DR   STRING; 353152.Q5CVP7; -.
DR   EnsemblProtists; EAK89707; EAK89707; cgd8_3260.
DR   GeneID; 3374337; -.
DR   KEGG; cpv:cgd8_3260; -.
DR   InParanoid; Q5CVP7; -.
DR   OMA; EMIQMLY; -.
DR   OrthoDB; 916229at2759; -.
DR   Proteomes; UP000006726; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR   Pfam; PF00514; Arm; 7.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 2.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 2.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PROSITE-
KW   ProRule:PRU00561}.
FT   DOMAIN          1..57
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          116..145
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          159..201
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          13..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EAK89707.1"
SQ   SEQUENCE   552 AA;  61553 MW;  CC9103683B46A01E CRC64;
     IGIIATMDKL ETHKKAYKKT FDDPRRKREE QQAQIRKQQR DEQLSKRRQG NDGENNDISM
     GMNIQSGNMY GVEHIPALSQ GIMSQEFTTQ FEATQGLRRL LSREHNPPIQ AVIDAGVIPR
     LVHFLSDYDH PNLQFEAAWT LTNISSGTTE QTCEVVRHGS IPKCVELLNS PKLEVKEQAI
     WTLGNIAGDS ANCRDLVLRA GALPPILQLI ALEIGPLDNN EQMMNVKSPS TVGGKVSGKT
     SILRTATWTV NNLCRGRPPP PFEMVSHSLP VLCRLLYFSD LEVMTDACWA LSYISDGPND
     RVEAVLRSEA CPRLVELLGH PSPLVQTPAL RCVGNIVTGD DRQTQMVLSC GAAKYLLQLL
     SSPKKVIRKE ACWTVSNITA GNKEQIQEII DNGLIVPLVN LLNTAEFDVK KEAAWAISNA
     TTGGTVEQIE YLVSQGVIKP LCDLLSIEDA KVINVALEAI ENILKTGAIR QHERGLQENP
     YCALVEQAYG LSRLEKLQEA PSKAIYEKAF HIIVSYFPYE YEDDHEEIFD TIESAEPEFK
     YNPDSNVDFK FE
//