ID Q5CXB4_CRYPI Unreviewed; 5542 AA.
AC Q5CXB4;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Tra1p-like C-terminal FAT domain plus phoshoinositide 3-kinase domain very large protein {ECO:0000313|EMBL:EAK89842.1};
GN ORFNames=cgd6_1740 {ECO:0000313|EMBL:EAK89842.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK89842.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK89842.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK89842.1}.
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DR EMBL; AAEE01000002; EAK89842.1; -; Genomic_DNA.
DR RefSeq; XP_627540.1; XM_627540.1.
DR STRING; 353152.Q5CXB4; -.
DR EnsemblProtists; EAK89842; EAK89842; cgd6_1740.
DR GeneID; 3376121; -.
DR KEGG; cpv:cgd6_1740; -.
DR VEuPathDB; CryptoDB:cgd6_1740; -.
DR InParanoid; Q5CXB4; -.
DR OMA; NEWNQMQ; -.
DR OrthoDB; 227373at2759; -.
DR Proteomes; UP000006726; Chromosome 6.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 2.
DR Pfam; PF20206; Tra1_ring; 2.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EAK89842.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Transferase {ECO:0000313|EMBL:EAK89842.1}.
FT DOMAIN 4088..4852
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 5131..5463
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 5505..5542
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 2661..2688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5542 AA; 630760 MW; 674C042599573A76 CRC64;
MNIKEVGTRL KSFGQNDFNE ELEFLTNIRD QIELYTTDKQ TYFSFLEECL DGIRNILLMN
DTAKKHDYKK SSIICMEIIS LLPQNEVISN YCSDLAQLCL HLLDRDTDDV GVLAIRNLVF
LHKNYTDKLE NVVESFLGFA SRLCTDVQHT LPQLIQEVIS NRNNNSSTEG QDIYIQSGNS
TTKSDKINSV NDDPDQLFFR GALSTTLPEL TEITNQVRSN VHRGPVTTNV NNTNPSQNLI
LPCHRSLRIL IELPLALLHI FQLYPHFIER YFAIFAPNLV SCLNIVSLFP RDFHPKLMGS
SCASQNHSIS QLKISPEQIP EIIRSSSFKS LVQDYMIACS KIILWFVHFF RGFNGDEHIS
ETLRQTQSAF IQGFIQVLLF CPPYCLHQRR EILVCLRSIL NTEFRQGFYD RIEILLDEAV
LIGHGRTGYE TLKVLSSAIL HEIIVYLRAE HSLNSYCNSL NQDSFFDSIM KCLHSLTRNI
LDTALPLPAQ HYCIRSAAFL PDILKKEGFV PSSNTQRNII IRDILLNILS IFSLKIHQLR
RQIYNLVLVS INKEIPGLPD SKTDSLTFTP LKPVLNDFLD EFIEISNIGN WLDNSFSYAN
TQIGHCEISI TGCSALKKGL DSETDMENQT KPLIIDVLRE LRPIIRATII GARQTIFHIT
TLNRNTIPSS DISNKNILNN NHSGMSGTTN NSNTNNVDIT RFDVRKLANG VMLNEAESKL
LQKILIEGII CSVEYCQCLQ YTMSSSGLFK IKEGGNECQI IPTSSLIIPN TIQSNYGANQ
HNNAVRQNNG AKPQQNSPLS IMPEEKELLE LLASVLCYIH PQSFGDIIQA TFSILFEWST
SMSPQISLIF HYWGVQQHTA KVFYESILPH LMLKLDTLAV EPNSKFTELR SKLSPIQILL
KSLNGKQLFS ESTQYDISSF IAQVNNMNIP STPLTCSIYP TEHHKLALSR YVVDPHIDNV
ESHSKIPYSR GRISHFGTPI QFPDAVQSVI DPRDDPNNLI NFAPTAAPHG NPDDHPFPFD
ILTQNINISL FQMQKNIIDL PIPDTFIYGG NSKNVNKDKT NEIASGLVST RLLKQLFRYI
GQNPQHETIL IPYVVDLCTL CTSMASKYQN NIFFLSILRS LFRSITPGGK ASGIYKEFLV
ILPWFLDTTI KMQKETKSPY REIWLEISLT VPARLKSLLP YMGQLISPML NALESNDPEL
VLLALRSLDL WIDNLHHDFL YPILTNSLHQ PHRFQTRPSI LVTLCKLLKP APPIPLPVSQ
VLLSNFHRYQ KNNSLSFYAL QSIAFQHATL VGRILGKLGG KNRWFLKDSA VLDVNDPLCV
KVPILIRPSP INNKLDTTLF LRIDDTLQHV YKYLSSISKK DFISSNKIIK NMCSTHIKNL
LLLYLSIFWT DIGTTESIKT FFNFLTSYLE KHSEKIENPN EATPFSMDYI SECNNFKAQS
SYSNNLELFA KSLILALSLI EELHDSVGEF CDGLTNYLAI YSASRSFIPE HCNLNLYWSN
TKTDPVAPIL SALFDTIDVQ FTISHNNHLK HTEPSYIALA AVKNMVNIYY NLVENFPLLY
FNRAFQTAQL PCLLESNIVN LCYDISWSKK TAACILIIEL LNHIPPIWAQ TYFQKLSDAL
FFISKDSGAD SNPFAERCSE DALDALIYSV FTGIKPFALF VNCENFSSKV IKIPISKYGI
TIPKNKLSLL SGESININDR NWEDLLTVIN ETNELKKNNS EFWWSNSYRV YMEMLITESK
DKWYSGVAIR DEIMNSLANN TPPDEILDIL RKHLFHLCMN SITPNILSLR PACRRMAQKC
LITLSNITGV SVATLLNTSF SSQFGNNDTN NLNATSQTTL LQQLLSRLQT KLISTCSTPY
QLAFLDTLCF LASLRPSPIG IPSTIIRRFV EDVFVVIRDE IDCEMNESQQ KNSNNSFSQS
NIQVNAQNSQ GNKGNPDFRK NKVQVQIYSI RFLKLILLHP NWSEFLRSRS NSSISVPVSA
NISPVISPAI PSNCSTQIHQ SSNFNQSNQL QHNSHQTNVN QGVQLQQTQQ PIPVLAQHIS
VNHPAQVGTQ SNHQNLQNVN QSKTQYPHQI YQNQHQTNIN QQFQMNSQLG INQTKTSQDE
LRWKIIGVLF RCVTRKDLEI CKAAHHTLKV IVRLERYLLN IDGIEDSNGN PNICNSSMNN
TNNSQYELLP EDQLRHCLRP VLVHLASATK LTVHVLQGLA RLLELLCFCF NVTLGEKLLQ
HLQRLCWPNE YQREVLNSSN QASSSIRQAQ NSSTGLANTQ IDTFNRYEED LHMAIAMVCI
FHLLPQGSDE FVSKVVGTIL GTRNFPGLDR SSNMQSSISS FITSYTTSMT ISSPFRLPLA
LFATHSPHNV VLFLIQQLAS DRYANFLIDL IKMSPCSVIR VKLYQLRTQL IESTVNRILE
EAENVENKCD SYIPTANFSQ VTGSSVQQNI NNSVVGAPQN INKANPNVIP VSPAFTESYS
SAWNGIRVLN SLCEEWPSLL VIDFLEYYAS SNRSALTIID ILLTMYNTIF NRLVVFTKSG
GISTHGNFDN KFELSLAYQG TVAWQHPWSF FHSNECFMLY KMLIGFYTAT NNLENVQNKE
YLEKKCYGNR VGDEIINDIL SVQNSMKSVL YSAVSLPSNT SSITNFSQSS TSSFQRQNLT
EDQTFSNSFS FTSHQMRQNI QNSNNNLNSS LHANNSHNSI SSTSNSTLNN QPIYPSKELI
ISLLSTIIHG QDVKEHLKRR RIDVILTIAT LFGTSSTLDS GAFRDFLICT VPKTLSNQEK
RLLFNQLIQR YYPSGPNIDT SSILPGTQIA CIQLILIPLL EYEFNRNNEK IRHSEDSWLN
DYICEGIITR IILPSLERNV IPLHGTNGLS ATDDPLKIEI LKLLILLVKN KYSLETISNN
RKRLIKDVWN ILRTESSLLK SWGYITMCYF VEKYPFPEKI LFSMLVALTR LYGVSEVRLT
VRRALNLFIP LLHNIKPIIK DDTLNIFSPE NESDKSLFSL IPSPPKLFIK DKTPETLFSN
WLRLMIAILI QDSYNLPLQQ QLYHWNIITL RPNIFAFEYI YLLSPVLSTL TKLLWGFGSV
GQNSSQSTSS SYAGSNSGMT NNFGQSAFPS NNILNIPFLP EMKRMIFGIL IVITNWVCNF
DAEVNIGVSS HCIDSDDNLE LKRRRISHSI SKDEKNNQSI CSGVGKEYRN VANATIDISS
IPQLAELLKI EDETSSVSII DLVITIWFRL ALLASSSDHK IVSKSFSTIS KIILIYPNCK
VQISWLDIGF NLSNNSHLSS ISSSTRSNIS QNPSTNSQGL NSQHQTISPN LIAFQLTLIA
GLQVFCIHQT SATIIMQLDS ILQILEPAFV SNDKNVSEAL YVLICKIIQI IPHPSTQLKD
SITKIVNFIY SNEENIQNSD RQPRELDYNY VDNFKVPLSK KLTVDNKIDS FYIRLIDIST
SGIWSLVNQE LSVLPELFPA KVTSNNQTTT NDNSNLLQYS EQTTNCSGRN ISLHTSIKII
SSFMVLGIAL NEQDVHKSQE ETTEIAVMFL RYFSPLIIYV LDKALAYYSS SNSQNLNSLQ
PSALSGKSNI SNANKNTNIS TSRSNTQNLN HTVSNALQHL NGSNTSILNN CADLFQLILI
SPYFTMKSLN SNVFRQHIIV LLRDFGLITF QGGIVHLLMS ILGRWIFNHQ LNINSYLSEK
LEIEVEEGSN LFVCNSLIVD SNESVENDFE GKRRIKVYNL DEILKFYSNL DYKNKTDETS
IKVLKYELVI TLLTGWSLIC DRNRRFEMHL IYHSFLEEIL NNHEDEILKI ILNYEGNLKA
KIEGSSNNIV LKQANTFVFT EKALTQLEKC ALLGLASPHP KIKLGFLKWF NEKLPKDLFG
RLRYLFTTSN FDVLAERFYI TQFLELLMPT MTFSEKSSII SNKMGAFPSI LPSIEQQIIN
KLDKSSNESY QSFKTNDFKT NLTEVELEWW ELQNLKLKEN YEDDNASTSS DISLICILDS
SSSDQSNSSL INRPQHNNFV AGQVKFDLLD DVIGNLKRNP GLAIDSLLFF SSTSESISIS
LWKTIFPWIW NNLEHQQRNE LTLDIIELLS KERHHRVSSA MPSEWTIPHV ILDSLLSCDN
PPILPATLLL HLSTKLRCWH IASNYLSNQI NTSNSQANIN KKENNFISKV NCNHDFKNNL
VQDDGPDSSW MILAQIYGEL QEEDIVIGIR RSFSNCLETH MGLALMQQAE WSKAQEIFYN
NLDAIYNSSS KATNSNADCS HNILNWARIF ENSDSSLLNN ETMIWIDSWV ACAKHLNQWN
TLNEFAKERR NPQLQLECSS KLQDWVLVEK LVNKYILHNP ITKLCQAYHS LYDLLLGGIN
NNWNLQSKGT QESLSNSSTN ISNQNRVNNS TNSQNLNNGA YCQQFSQSII QNSSRSKLAE
FERHCSIGYR TVLNFWAMLP SVVTTCHVPL LLNFQQYIEL QEGFRLSSDI ERKLYPDGPN
SNINHSLNGN IVQNTANFGS NYIIHHSNAN NLAQSSQSIN TGNPNSHVNI NSHSNLQNTS
NSTPGYFEAR MLNVWRDRLP NKWDSMILWN DLFVWRNFVF SIIMNLISRS DHLTSQAKSL
WPSYLQDMPW TMIKFASIAR KSHRLPEVSV ALLQRLQNHL QVSGGDAYRA ETFLATLEKV
KLCLSDTTQL RTGLNILNMT DFQKCPEPYF DEYRAEFLRL KGIISNKLYP NYYIDGEIPN
NANSVTGSNV LNSEQGHPGL NNTSATGIST SVVRVNADLL SSLKVYPLFA RGWITWAQYT
DRLLYIHQNM SYAVNAVISY LMGIYLRPDK YSILLSRVLW LLPHDSPDGK YLSLAFKKYS
DHLPCAVWLP WIPQLIAGID RIEGSAILHI LNKIVLIFPQ SIYFNIRSSY LEKREMAHMY
WYLSSNSETE NTSQGPPPPP SSGIYPSFIS LGWQRIESLM NTCRIRHGAL TLALEHWVED
IVLHCKPDPL DELLCAIRTL FQMTIEISPI NDESIIVQDS NLSDTKASDI FPNIGTHFLE
HNIIRRYEQL LNKSSSLNNK SFERSKNIIK QYWNEFKNDF HVYLCNNTNP PIERVSQLKL
DYVLEKLKKW KDHFTKCTER YSNENIRGKS LLSDFSTTLC DLFHRINIRL EVPGQYLRIV
SESLYLRNFA VLENTNSNNP IGGVIYLHRS LPTVETVVRQ SYTLKRIGFI TSSGSTIHFL
IQPYSGLQQK VEERILHLQV TLNTLLYKYK ETRSRNISFA IQPCIPLHPR CRIIEDTGNK
KSFTELFEEE ANSSNCTCPI KDLDFPILLH RKLINISLRK LNNINNSQLD KEMLKIYTEL
CDNWVPDNIF KRSILRKFNS HDQSFLFTKQ FTTHLGLLSI FSYILGVNDV TPGKLFISLD
TGQVYQSELK SSYVSSTLLI DKTEKVPFRL TRNMEHLMGP FGKNGILPGT MLAFAQCLQK
YEFHVRNLLC SLLRDDLHAF SVHRALQIPQ NRNLYQKPNN PSVESDFDNS SQTVINSPNT
ANDHSQNTIS QIMQQRLLSN VEIREKVDRN VRRMMEKIAV LTNPRPINEN SQLIDRSVLE
LIECSTDPKN LSAMKPTWMP WL
//
