ID Q5CY84_CRYPI Unreviewed; 873 AA.
AC Q5CY84;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=E3 ubiquitin-protein ligase CHFR {ECO:0000256|ARBA:ARBA00017908};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=cgd7_3320 {ECO:0000313|EMBL:EAK90333.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAK90333.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAK90333.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- SIMILARITY: Belongs to the CHFR family.
CC {ECO:0000256|ARBA:ARBA00005797}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAK90333.1}.
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DR EMBL; AAEE01000001; EAK90333.1; -; Genomic_DNA.
DR RefSeq; XP_628496.1; XM_628494.1.
DR AlphaFoldDB; Q5CY84; -.
DR STRING; 353152.Q5CY84; -.
DR EnsemblProtists; EAK90333; EAK90333; cgd7_3320.
DR GeneID; 3372048; -.
DR KEGG; cpv:cgd7_3320; -.
DR VEuPathDB; CryptoDB:cgd7_3320; -.
DR InParanoid; Q5CY84; -.
DR OMA; YNIEETH; -.
DR OrthoDB; 5479648at2759; -.
DR Proteomes; UP000006726; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR23328:SF0; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23328; UNCHARACTERIZED; 1.
DR Pfam; PF00498; FHA; 2.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00240; FHA; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 80..118
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 573..647
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
SQ SEQUENCE 873 AA; 99450 MW; FD39DDB1977145B7 CRC64;
MINNNMIKRE VVNERKQDCE HGSDIINNKD NMFNITVNTE PYDVLENDIM KNKSRKVNNS
SKNGFESTNI SNKILSEFTC PVCLDYYMLP VTIPCGHTFC RYCITHNRLL GKKCPVCRQL
IGYNFRINMT IHNVIVSLGI FKQIENSSQD ERLYNEILLT NNELIGQNRP KWWQLCFCKP
IISVTLFARI ISDEILGIGI VFAEDLTRCI IDHLSKLSSI IQDKKLKSMI WSNGIYMIGP
LEVNLLTKWM GCPPLPFKLD DKETGNLEKN SDFTLNNNAI FKNQVKKWVE ECIALKPTIL
NIGQSPFTKT STYPILRILS DRIHRVESKI YDLGALRSPL PWDLGRHSKS TIQVSHSSVS
TNHLLIVNIK EHDQVAQELK YKSNTSHKFD ESSPIEKDWG IGVIDLGSSI GTMLKIQPKH
RLATDEVIHL ADRVEIIVKI RKIEEITNED NLNGDSRILI NEWKKLRWSN KLNLVINIDD
YNKGEHKTIN RAKNSDFEDL FGICNDKDKL DSSELSQESK IVQVPLEELE IEEIKECLEV
YIPIGSKSFV PCEGAKKTEN GMYWSVIVHP SGMVFGRGKN GALGLRKVEV TESNGYISRE
HCIFYYSSIR NREYEGLDYL SRSNGCLSNW FVKDVSTSGT FLRLKPFSYP VRVLPGMVLK
VGQCKMEILP YMIGALYSGQ PNSSVRNNSI NLVSQDFQPI QTNLTEVESS QTHVSNTNQI
PIPYLSNSAL FTQTLNDQYL SNINNNVIAQ LNILAAYNYI NSSSITNLVN SNNIVEFNNQ
TYEDRIIQRQ NSSFDNIILQ SILRNSIVNN NILSAGHYLG NIQTSEDNSI TGGSIGSLEV
NSILNYDRRP REPRVTQEVD VSFQIESFEN EDC
//
