ID Q5E9S7_BOVIN Unreviewed; 457 AA.
AC Q5E9S7; F1MYT5;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 13-SEP-2023, entry version 132.
DE SubName: Full=RasGEF domain family, member 1A {ECO:0000313|EMBL:AAX08860.1};
GN Name=RASGEF1A {ECO:0000313|EMBL:AAX08860.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAX08860.1};
RN [1] {ECO:0000313|EMBL:AAX08860.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX08860.1};
RX PubMed=11282978; DOI=10.1101/gr.170101;
RA Smith T.P., Grosse W.M., Freking B.A., Roberts A.J., Stone R.T., Casas E.,
RA Wray J.E., White J., Cho J., Fahrenkrug S.C., Bennett G.L., Heaton M.P.,
RA Laegreid W.W., Rohrer G.A., Chitko-McKown C.G., Pertea G., Holt I.,
RA Karamycheva S., Liang F., Quackenbush J., Keele J.W.;
RT "Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries
RT and construction of a gene index for cattle.";
RL Genome Res. 11:626-630(2001).
RN [2] {ECO:0000313|EMBL:AAX08860.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pooled {ECO:0000313|EMBL:AAX08860.1};
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
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DR EMBL; BT020843; AAX08860.1; -; mRNA.
DR RefSeq; NP_001015601.1; NM_001015601.1.
DR AlphaFoldDB; Q5E9S7; -.
DR SMR; Q5E9S7; -.
DR GeneID; 514877; -.
DR KEGG; bta:514877; -.
DR CTD; 221002; -.
DR eggNOG; KOG3541; Eukaryota.
DR HOGENOM; CLU_022907_3_0_1; -.
DR TreeFam; TF313379; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF172; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1A; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 17..146
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 190..437
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 457 AA; 52254 MW; 5780810F8064082C CRC64;
MGERGGGAGG SGDLIFQDGR LISGSLEALM EHLVPTVDYY PDRTYIFTFL LSSRVFIPPH
DLLARVGQLC VEQRQQLEAG SEKAKLKSFS AKIVQLLKEW TEAFPFDFQD EKAMAELKAI
THRVTQCDEE NGTVKKAISQ MTQSLLLSLA ARSQLQELRE KLRSPAMDKG PVLKAKPPAA
QKDILGVCCD PLVLAQQLTH IELERVSSIH PEDLMQIVSH MDSRDKHRCR GDMTKTYSLE
AYDNWFNCLS MLVATEVCRV VKKKHRTRML EFFIDVAREC FNIGNFNSMM AIISGMNLSP
VARLKKTWSK VKTAKFDVLE HHMDPSSNFC NYRTALQGAT QRSQTANSSR EKIVIPVFNL
FVKDIYFLHK IHTNHLPNGH INFKKFWEIS RQIHEFMTWT QVECPFEKDK KIQSYLLTAP
IYSEEALFIA SFESEGPENH MEKDSWKTLR TTLLNRA
//
