GenomeNet

Database: UniProt
Entry: Q5EA46
LinkDB: Q5EA46
Original site: Q5EA46 
ID   CREL1_BOVIN             Reviewed;         420 AA.
AC   Q5EA46; Q58CS1;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   16-JAN-2019, entry version 83.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 1;
DE   Flags: Precursor;
GN   Name=CRELD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX46723.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305};
DR   EMBL; BT020723; AAX08740.1; -; mRNA.
DR   EMBL; BT021876; AAX46723.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001014851.3; NM_001014851.3.
DR   UniGene; Bt.5333; -.
DR   ProteinModelPortal; Q5EA46; -.
DR   SMR; Q5EA46; -.
DR   STRING; 9913.ENSBTAP00000014377; -.
DR   PaxDb; Q5EA46; -.
DR   PRIDE; Q5EA46; -.
DR   GeneID; 504854; -.
DR   KEGG; bta:504854; -.
DR   CTD; 78987; -.
DR   eggNOG; KOG4260; Eukaryota.
DR   eggNOG; ENOG41107X2; LUCA.
DR   HOGENOM; HOG000004778; -.
DR   HOVERGEN; HBG081344; -.
DR   InParanoid; Q5EA46; -.
DR   OrthoDB; 883628at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 1.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     29       {ECO:0000255}.
FT   CHAIN        30    420       Cysteine-rich with EGF-like domain
FT                                protein 1.
FT                                /FTId=PRO_0000042780.
FT   TOPO_DOM     30    362       Extracellular. {ECO:0000255}.
FT   TRANSMEM    363    383       Helical. {ECO:0000255}.
FT   TOPO_DOM    384    384       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    385    405       Helical. {ECO:0000255}.
FT   TOPO_DOM    406    420       Extracellular. {ECO:0000255}.
FT   DOMAIN      153    193       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      208    255       FU 1.
FT   REPEAT      268    315       FU 2.
FT   DOMAIN      305    344       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    205    205       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    155    169       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    163    181       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    183    192       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    309    321       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    314    330       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    332    343       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CONFLICT    346    346       D -> E (in Ref. 1; AAX46723).
FT                                {ECO:0000305}.
SQ   SEQUENCE   420 AA;  45368 MW;  D6332A491CF08B91 CRC64;
     MAPRSSRGIA PAMLCGLSLF LGFPGLVWVQ ISVPPQSSPH TEPHPCHTCR GLVDSFNKGL
     ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSK SDFECHRLLE LSEELVESWW
     FHKQQEAPDL FQWLCSDSLK LCCPSGTFGP SCLPCPGGAE RPCGGYGHCE GEGTRGGSGH
     CDCQAGYGGE ACGQCGLGYF EAERNASHLV CSACFGPCAR CSGPEESHCL QCKKGWALHH
     LKCVDIDECG TERASCGADQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSPGYQQVG
     SKCLDVDECE TAVCPGENQQ CENTEGSYRC ICADGYKQME GICVKDQIPE SAGFFSEMTE
     DELVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM TGYWLSERSD RVLEGFIKGR
//
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