ID ELP2_XENTR Reviewed; 824 AA.
AC Q5EBD9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Elongator complex protein 2;
DE Short=ELP2;
GN Name=elp2;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the elongator complex which is required for
CC multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl
CC uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U
CC (5-carbamoylmethyl uridine). The elongator complex catalyzes the
CC formation of carboxymethyluridine in the wobble base at position 34 in
CC tRNAs. {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC biosynthesis. {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- SUBUNIT: Component of the elongator complex.
CC {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6IA86}. Nucleus
CC {ECO:0000250|UniProtKB:Q6IA86}.
CC -!- DOMAIN: Folds into a two seven-bladed beta-propeller structure which is
CC required for elongator complex assembly.
CC {ECO:0000250|UniProtKB:P42935}.
CC -!- SIMILARITY: Belongs to the WD repeat ELP2 family. {ECO:0000305}.
CC -!- CAUTION: The elongator complex was originally thought to play a role in
CC transcription elongation. However, it is no longer thought to play a
CC direct role in this process and its primary function is thought to be
CC in tRNA modification. {ECO:0000250|UniProtKB:Q6IA86}.
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DR EMBL; BC089753; AAH89753.1; -; mRNA.
DR RefSeq; NP_001015799.1; NM_001015799.1.
DR AlphaFoldDB; Q5EBD9; -.
DR SMR; Q5EBD9; -.
DR STRING; 8364.ENSXETP00000014687; -.
DR PaxDb; 8364-ENSXETP00000041056; -.
DR GeneID; 548516; -.
DR KEGG; xtr:548516; -.
DR AGR; Xenbase:XB-GENE-5752362; -.
DR CTD; 55250; -.
DR Xenbase; XB-GENE-5752362; elp2.
DR eggNOG; KOG1063; Eukaryota.
DR HOGENOM; CLU_006430_1_0_1; -.
DR InParanoid; Q5EBD9; -.
DR OrthoDB; 22040at2759; -.
DR UniPathway; UPA00988; -.
DR Proteomes; UP000008143; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033588; C:elongator holoenzyme complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR GO; GO:0061133; F:endopeptidase activator activity; ISS:UniProtKB.
DR GO; GO:0043248; P:proteasome assembly; ISS:UniProtKB.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR037289; Elp2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44111; ELONGATOR COMPLEX PROTEIN 2; 1.
DR PANTHER; PTHR44111:SF1; ELONGATOR COMPLEX PROTEIN 2; 1.
DR Pfam; PF00400; WD40; 7.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; tRNA processing; WD repeat.
FT CHAIN 1..824
FT /note="Elongator complex protein 2"
FT /id="PRO_0000284001"
FT REPEAT 14..51
FT /note="WD 1"
FT REPEAT 54..98
FT /note="WD 2"
FT REPEAT 103..147
FT /note="WD 3"
FT REPEAT 153..195
FT /note="WD 4"
FT REPEAT 200..241
FT /note="WD 5"
FT REPEAT 278..326
FT /note="WD 6"
FT REPEAT 336..375
FT /note="WD 7"
FT REPEAT 383..422
FT /note="WD 8"
FT REPEAT 433..471
FT /note="WD 9"
FT REPEAT 562..606
FT /note="WD 10"
FT REPEAT 609..648
FT /note="WD 11"
FT REPEAT 664..703
FT /note="WD 12"
FT REPEAT 718..764
FT /note="WD 13"
FT REPEAT 784..824
FT /note="WD 14"
SQ SEQUENCE 824 AA; 92123 MW; 9BAF9A4F9B8666FA CRC64;
MSAPIVQLAH AAFSVNRCPS CVSWSRTGIL ACATCHSIAL YDPQKNVVIS TLNGHTGRVN
CVHWVQKNDC SAETELVSGG SDKKVIIWAI EKNKCEQPVA AEGHTEVVNA VHAVYTQRSE
NELLIVSAAS DCTVRLWLRR NVKTECLQTL SFGKGFVLDV CISFLPGSLV PVLACGADDS
RIHLYVLQNE QFEKTQVLHG HEDWIRGVEW AVTGQNLFLA SCAQDCLIRI WKIFRKTAKE
NSKTEDENSI KLKENIFKVK EKDTETSYAV TLETVLTGHE NSIYAVHWQP SFSRDGSIVQ
PMSLLSASMD KTMILWEPDE ESGVWLEQVR VGEVGGNTLG FLGCQFSPDK SMILAHAFHG
ALHLWSRAPN KQNEWIPMVI ISGHFDSVQD MRWDPDGQFV ITVSADQTTR LFGPWKKKGQ
SHVTWHEIAR PQIHGYDMQC LAMIGRFQFV SGADEKVLRV FAAPRNFIEN FSNISCISVE
KLLLNEDTNL PEGATVPALG LSNKAVFHGE ILIQSTQEEG KYNSVSEQYS QPNFQPLNLT
EPPTEDHLLQ NTLWPEVQKL YGHGYEIFAV ACNSAKTVIA SACKASKREH AAIILWSTTS
WKQLQSLSYH NLTVTQMAFS PDDEFLLVVS RDRNWSLWKK QEGIPEQTEP TFTLYASTDK
NSCVHSRIIW ACDWTPDSKY FVTGSRDKKV IVWGDCSLPS MNEEKSSALI RPCSSLLDTG
DSITAVSVSQ VLALDGSYII AVGLDCGIIQ LYKWKHSGTV NDWLKCLAMD QSLLSHTLTV
KQLCWRSCLG RAGHDDRDNG DWIQLASCGA DHCVKIFDVY RKAL
//
