ID Q5EP54_HUMAN Unreviewed; 258 AA.
AC Q5EP54;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 07-APR-2021, entry version 152.
DE SubName: Full=HLA class II histocompatibility antigen DP beta chain {ECO:0000313|EMBL:BBD34212.1};
DE SubName: Full=HLA class II histocompatibility antigen, DP beta 1 chain {ECO:0000313|Ensembl:ENSP00000399298};
DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AAW78739.1};
GN Name=HLA-DPB1 {ECO:0000313|EMBL:AAW78739.1,
GN ECO:0000313|Ensembl:ENSP00000399298};
GN Synonyms=DPB1 {ECO:0000313|EMBL:QBG49716.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAW78739.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000399298, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|EMBL:AAW78739.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16189666; DOI=10.1007/s00251-005-0043-8;
RA Reinders J., Rozemuller E.H., van Gent R., Arts-Hilkes Y.H.,
RA van den Tweel J.G., Tilanus M.G.J.;
RT "Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing.";
RL Immunogenetics 57:790-794(2005).
RN [3] {ECO:0000313|EMBL:ABC66207.1}
RP NUCLEOTIDE SEQUENCE.
RA Song C.-H., Lee J.-K., Koh I., Lee J.-Y., Lim Y.-H., Kang J., Cha Y.-Y.,
RA Yun H.-S., Lee E.-J., Kwack K.;
RT "Identification of HLA-DPB1*020102 allele variant, in the Korean
RT population.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:BAN59793.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23714642; DOI=10.1186/1471-2164-14-355;
RA Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.;
RT "Phase-defined complete sequencing of the HLA genes by next-generation
RT sequencing.";
RL BMC Genomics 14:355-355(2013).
RN [5] {ECO:0000313|EMBL:AMT81697.1}
RP NUCLEOTIDE SEQUENCE.
RA Marino S.R., Brown N.K., West T.A., Issangya B.M., Upchurch R.L.;
RT "Novel HLA alleles identified and characterized by an NGS-based typing
RT assay.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Ensembl:ENSP00000399298}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2016) to UniProtKB.
RN [7] {ECO:0000313|EMBL:SIT60286.1}
RP NUCLEOTIDE SEQUENCE.
RA Song W.-J., Kurnit D.M.;
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:SMY43988.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28547825; DOI=10.1111/tan.13057;
RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., Dahl A.,
RA Winkler S., Lange V., Bohme I., Schmidt A.H.;
RT "Dual redundant sequencing strategy: Full-length gene characterisation of
RT 1056 novel and confirmatory HLA alleles.";
RL HLA 90:79-87(2017).
RN [9] {ECO:0000313|EMBL:SIT60286.1}
RP NUCLEOTIDE SEQUENCE.
RA Lang K., Schoefl G., Schmidt A., Lange V.;
RT "Complementing the HLA-DPB1 Database: Full-Length Gene Characterization of
RT all Common and Well-Documented Alleles.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:SJK83216.1}
RP NUCLEOTIDE SEQUENCE.
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:AVI26629.1}
RP NUCLEOTIDE SEQUENCE.
RA Balz V., Krause S., Enzcmann J., Fischer J.;
RT "Determination of full gene HLA-DPB1 sequences and variations thereof.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:SMZ62531.1}
RP NUCLEOTIDE SEQUENCE.
RA Albrecht V., Zweiniger C., Boehme I., Schmidt A.H.;
RT "Characterisation and Confirmation of new HLA alleles found by DKMS Life
RT Science Lab.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:BBD34212.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30337930; DOI=.3389/fimmu.2018.02294;
RA Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., Oka A.,
RA Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., Morishima S.,
RA Morishima Y., Inoko H., Kulski J.K., Shiina T.;
RT "Reference Grade Characterization of Polymorphisms in Full-Length HLA Class
RT I and II Genes With Short-Read Sequencing on the ION PGM System and Long-
RT Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio
RT Platform.";
RL Front. Immunol. 9:2294-2294(2018).
RN [14] {ECO:0000313|EMBL:QBG49716.1}
RP NUCLEOTIDE SEQUENCE.
RA Balz V., Enczmann J., Fischer J.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:SPT23801.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhirakovskaya E.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [16] {ECO:0000313|EMBL:SUQ66061.1}
RP NUCLEOTIDE SEQUENCE.
RA Quirk P.G., Krulwich T.A.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [17] {ECO:0000313|EMBL:SUQ66081.1}
RP NUCLEOTIDE SEQUENCE.
RA Albrecht V., Albrecht V.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [18] {ECO:0000313|EMBL:VEM23648.1}
RP NUCLEOTIDE SEQUENCE.
RA Albrecht V.;
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN [19] {ECO:0000313|EMBL:VIO51626.1}
RP NUCLEOTIDE SEQUENCE.
RA Turner R T.;
RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN [20] {ECO:0000313|EMBL:CAA7154599.1}
RP NUCLEOTIDE SEQUENCE.
RA Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.;
RL Submitted (JAN-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004352}.
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DR EMBL; CR847849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY804134; AAW78739.1; -; mRNA.
DR EMBL; DQ284441; ABC66207.1; -; mRNA.
DR EMBL; KU745858; AMT81697.1; -; Genomic_DNA.
DR EMBL; KY801329; AVI26629.1; -; Genomic_DNA.
DR EMBL; KY801330; AVI26630.1; -; Genomic_DNA.
DR EMBL; KY801331; AVI26631.1; -; Genomic_DNA.
DR EMBL; KY801332; AVI26632.1; -; Genomic_DNA.
DR EMBL; KY801333; AVI26633.1; -; Genomic_DNA.
DR EMBL; AB774947; BAN59793.1; -; Genomic_DNA.
DR EMBL; LC257894; BBD34212.1; -; Genomic_DNA.
DR EMBL; LC257895; BBD34213.1; -; Genomic_DNA.
DR EMBL; LC257896; BBD34214.1; -; Genomic_DNA.
DR EMBL; LC257897; BBD34215.1; -; Genomic_DNA.
DR EMBL; LC257898; BBD34216.1; -; Genomic_DNA.
DR EMBL; LC257899; BBD34217.1; -; Genomic_DNA.
DR EMBL; LC257900; BBD34218.1; -; Genomic_DNA.
DR EMBL; LC257901; BBD34219.1; -; Genomic_DNA.
DR EMBL; LR745772; CAA7154599.1; -; Genomic_DNA.
DR EMBL; MH491537; QBG49716.1; -; Genomic_DNA.
DR EMBL; LT707787; SIT60286.1; -; Genomic_DNA.
DR EMBL; LT707788; SIT60287.1; -; Genomic_DNA.
DR EMBL; LT707800; SIT60299.1; -; Genomic_DNA.
DR EMBL; LT707801; SIT60300.1; -; Genomic_DNA.
DR EMBL; LT707854; SIT60353.1; -; Genomic_DNA.
DR EMBL; LT707855; SIT60354.1; -; Genomic_DNA.
DR EMBL; LT707856; SIT60355.1; -; Genomic_DNA.
DR EMBL; LT707857; SIT60356.1; -; Genomic_DNA.
DR EMBL; LT707858; SIT60357.1; -; Genomic_DNA.
DR EMBL; LT707859; SIT60358.1; -; Genomic_DNA.
DR EMBL; LT707860; SIT60359.1; -; Genomic_DNA.
DR EMBL; LT707861; SIT60360.1; -; Genomic_DNA.
DR EMBL; LT707862; SIT60361.1; -; Genomic_DNA.
DR EMBL; LT707863; SIT60362.1; -; Genomic_DNA.
DR EMBL; LT707864; SIT60363.1; -; Genomic_DNA.
DR EMBL; LT707865; SIT60364.1; -; Genomic_DNA.
DR EMBL; LT707866; SIT60365.1; -; Genomic_DNA.
DR EMBL; LT707867; SIT60366.1; -; Genomic_DNA.
DR EMBL; LT707868; SIT60367.1; -; Genomic_DNA.
DR EMBL; LT707869; SIT60368.1; -; Genomic_DNA.
DR EMBL; LT707870; SIT60369.1; -; Genomic_DNA.
DR EMBL; LT707871; SIT60370.1; -; Genomic_DNA.
DR EMBL; LT707872; SIT60371.1; -; Genomic_DNA.
DR EMBL; LT707873; SIT60372.1; -; Genomic_DNA.
DR EMBL; LT718901; SJK83216.1; -; Genomic_DNA.
DR EMBL; LT718902; SJK83217.1; -; Genomic_DNA.
DR EMBL; LT718903; SJK83218.1; -; Genomic_DNA.
DR EMBL; LT718904; SJK83219.1; -; Genomic_DNA.
DR EMBL; LT718905; SJK83220.1; -; Genomic_DNA.
DR EMBL; LT718906; SJK83221.1; -; Genomic_DNA.
DR EMBL; LT718907; SJK83222.1; -; Genomic_DNA.
DR EMBL; LT718908; SJK83223.1; -; Genomic_DNA.
DR EMBL; LT718909; SJK83224.1; -; Genomic_DNA.
DR EMBL; LT718910; SJK83225.1; -; Genomic_DNA.
DR EMBL; LT718912; SJK83227.1; -; Genomic_DNA.
DR EMBL; LT718913; SJK83228.1; -; Genomic_DNA.
DR EMBL; LT718914; SJK83229.1; -; Genomic_DNA.
DR EMBL; LT718915; SJK83230.1; -; Genomic_DNA.
DR EMBL; LT718916; SJK83231.1; -; Genomic_DNA.
DR EMBL; LT718917; SJK83232.1; -; Genomic_DNA.
DR EMBL; LT718918; SJK83233.1; -; Genomic_DNA.
DR EMBL; LT718919; SJK83234.1; -; Genomic_DNA.
DR EMBL; LT718920; SJK83235.1; -; Genomic_DNA.
DR EMBL; LT718921; SJK83236.1; -; Genomic_DNA.
DR EMBL; LT718922; SJK83237.1; -; Genomic_DNA.
DR EMBL; LT718923; SJK83238.1; -; Genomic_DNA.
DR EMBL; LT719017; SJK83332.1; -; Genomic_DNA.
DR EMBL; LT882732; SMY43988.1; -; Genomic_DNA.
DR EMBL; LT882733; SMY43989.1; -; Genomic_DNA.
DR EMBL; LT882771; SMY44028.1; -; Genomic_DNA.
DR EMBL; LT883489; SMZ62531.1; -; Genomic_DNA.
DR EMBL; LT883490; SMZ62532.1; -; Genomic_DNA.
DR EMBL; LT883497; SMZ62539.1; -; Genomic_DNA.
DR EMBL; LT883498; SMZ62540.1; -; Genomic_DNA.
DR EMBL; LT883504; SMZ62546.1; -; Genomic_DNA.
DR EMBL; LS480665; SPT23801.1; -; Genomic_DNA.
DR EMBL; LS480666; SPT23802.1; -; Genomic_DNA.
DR EMBL; LS990961; SUQ66061.1; -; Genomic_DNA.
DR EMBL; LS990971; SUQ66071.1; -; Genomic_DNA.
DR EMBL; LS990972; SUQ66072.1; -; Genomic_DNA.
DR EMBL; LS990973; SUQ66073.1; -; Genomic_DNA.
DR EMBL; LS990981; SUQ66081.1; -; Genomic_DNA.
DR EMBL; LS990987; SUQ66087.1; -; Genomic_DNA.
DR EMBL; LS990990; SUQ66090.1; -; Genomic_DNA.
DR EMBL; LR137069; VEM23648.1; -; Genomic_DNA.
DR EMBL; LR137083; VEM23662.1; -; Genomic_DNA.
DR EMBL; LR137084; VEM23663.1; -; Genomic_DNA.
DR EMBL; LR137108; VEM23687.1; -; Genomic_DNA.
DR EMBL; LR137119; VEM23698.1; -; Genomic_DNA.
DR EMBL; LR137121; VEM23700.1; -; Genomic_DNA.
DR EMBL; LR585253; VIO51626.1; -; Genomic_DNA.
DR EMBL; LR585286; VIO51659.1; -; Genomic_DNA.
DR EMBL; LR585303; VIO51676.1; -; Genomic_DNA.
DR SMR; Q5EP54; -.
DR MaxQB; Q5EP54; -.
DR PRIDE; Q5EP54; -.
DR ProteomicsDB; 62775; -.
DR Ensembl; ENST00000415996; ENSP00000399298; ENSG00000229295.
DR UCSC; uc011hgd.3; human.
DR HGNC; HGNC:4940; HLA-DPB1.
DR OMA; ICQVEHT; -.
DR ChiTaRS; HLA-DPB1; human.
DR Proteomes; UP000005640; Chromosome 6.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.10.320.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR000353; MHC_II_b_N.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00969; MHC_II_beta; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00921; MHC_II_beta; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius}; MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Proteomics identification {ECO:0007829|MaxQB:Q5EP54,
KW ECO:0007829|PeptideAtlas:Q5EP54, ECO:0007829|ProteomicsDB:Q5EP54};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..258
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015097870"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 258 AA; 29290 MW; BD74758796CA4B5B CRC64;
MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN
REEFVRFDSD VGEFRAVTEL GRPDEEYWNS QKDILEEERA VPDRMCRHNY ELGGPMTLQR
RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW
TFQILVMLEM TPQQGDVYTC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC
GVGIFMHRRS KKVQRGSA
//
