ID Q5F247_MOUSE Unreviewed; 422 AA.
AC Q5F247;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Smoothelin-like 2 {ECO:0000313|Ensembl:ENSMUSP00000104140.2};
GN Name=Smtnl2 {ECO:0000313|Ensembl:ENSMUSP00000104140.2,
GN ECO:0000313|MGI:MGI:2442764};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000104140.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000104140.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104140.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000104140.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000104140.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; Q5F247; -.
DR SMR; Q5F247; -.
DR jPOST; Q5F247; -.
DR MaxQB; Q5F247; -.
DR ProteomicsDB; 320580; -.
DR Antibodypedia; 11245; 79 antibodies from 20 providers.
DR Ensembl; ENSMUST00000108500.8; ENSMUSP00000104140.2; ENSMUSG00000045667.15.
DR AGR; MGI:2442764; -.
DR MGI; MGI:2442764; Smtnl2.
DR VEuPathDB; HostDB:ENSMUSG00000045667; -.
DR GeneTree; ENSGT00940000154495; -.
DR HOGENOM; CLU_040651_5_0_1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000045667; Expressed in sternocleidomastoid and 156 other cell types or tissues.
DR ExpressionAtlas; Q5F247; baseline and differential.
DR CDD; cd21261; CH_SMTNL2; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR23167; CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED; 1.
DR PANTHER; PTHR23167:SF37; SMOOTHELIN-LIKE PROTEIN 2; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|EPD:Q5F247,
KW ECO:0007829|MaxQB:Q5F247};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 312..419
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 87..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..53
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 120..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..248
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 45820 MW; BCBFC5F532A562DF CRC64;
MQGLQRGVER RVAEALRLAG PLARTVAELQ RDNQRLQAQL ERLTRQVEAL GLATGVSPAP
GTPSPPPAAT VTDRAPRLGT ARFSSHATFS LSGRSPSVEH DEASDLEVRR ASNSCILENG
HQLDAGPANG SSEVQTSSAQ EPPRPRPVSL SLRMPHQPVT AVTRVSEKFS GETSASALSP
TSAAIVGGFT PSPSEAISPW TPSPTEKSSS FTRSLSGSGY GAVTAGKRKD SPPLVTPPQS
PPSSQPPAMT QAPRQGERRR ELVRSQTLPR TSGAQARKAL FEKWEQDTAS KGKGETRAKL
KRSQSFGVAS ASSIKQILLE WCRSKTVGYQ HVDLQNFSSS WSDGMAFCAL VHSFFPDAFD
YNALSPTQRQ KNFELAFTMA ENLANCERLI EVEDMMVMGR KPDPMCVFTY VQSLYNHLRR
FE
//
