ID Q5F2A4_MOUSE Unreviewed; 240 AA.
AC Q5F2A4;
DT 10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=Tumor necrosis factor (ligand) superfamily, member 13 {ECO:0000313|Ensembl:ENSMUSP00000018896.8};
GN Name=Tnfsf13 {ECO:0000313|Ensembl:ENSMUSP00000018896.8,
GN ECO:0000313|MGI:MGI:1916833};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000018896.8, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1};
RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA Hayashizaki Y.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [7] {ECO:0000313|EMBL:BAE41739.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE21985.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE21985.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [9] {ECO:0000313|EMBL:BAC30661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30661.1}, and NOD
RC {ECO:0000313|EMBL:BAE41739.1};
RC TISSUE=Aorta and vein {ECO:0000313|EMBL:BAC30661.1}, and Thymus
RC {ECO:0000313|EMBL:BAE21985.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [10] {ECO:0000313|Ensembl:ENSMUSP00000018896.8, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018896.8,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [11] {ECO:0000313|Ensembl:ENSMUSP00000018896.8}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000018896.8};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AK040667; BAC30661.1; -; mRNA.
DR EMBL; AK134028; BAE21985.1; -; mRNA.
DR EMBL; AK170351; BAE41739.1; -; mRNA.
DR RefSeq; NP_001152977.1; NM_001159505.1.
DR RefSeq; NP_076006.2; NM_023517.2.
DR Antibodypedia; 1191; 895 antibodies from 45 providers.
DR DNASU; 69583; -.
DR Ensembl; ENSMUST00000018896.14; ENSMUSP00000018896.8; ENSMUSG00000089669.8.
DR GeneID; 69583; -.
DR KEGG; mmu:69583; -.
DR UCSC; uc007jre.1; mouse.
DR AGR; MGI:1916833; -.
DR CTD; 8741; -.
DR MGI; MGI:1916833; Tnfsf13.
DR VEuPathDB; HostDB:ENSMUSG00000089669; -.
DR GeneTree; ENSGT00940000161488; -.
DR HOGENOM; CLU_1234667_0_0_1; -.
DR OMA; MAYNTCY; -.
DR OrthoDB; 5358224at2759; -.
DR TreeFam; TF332331; -.
DR BioGRID-ORCS; 69583; 3 hits in 113 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 11.
DR Bgee; ENSMUSG00000089669; Expressed in layer of retina and 65 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15151; PROTEIN EIGER; 1.
DR PANTHER; PTHR15151:SF12; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..240
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 240 AA; 26818 MW; 27A2E7356D9903B2 CRC64;
MPASSPGHMG GSVREPALSV ALWLSWGAVL GAVTCAVALL IQQTELQSLR REVSRLQRSG
GPSQKQGERP WQSLWEQSPD VLEAWKDGAK SRRRRAVLTQ KHKKKHSVLH LVPVNITSKD
SDVTEVMWQP VLRRGRGLEA QGDIVRVWDT GIYLLYSQVL FHDVTFTMGQ VVSREGQGRR
ETLFRCIRSM PSDPDRAYNS CYSAGVFHLH QGDIITVKIP RANAKLSLSP HGTFLGFVKL
//
