ID Q5F393_CHICK Unreviewed; 1510 AA.
AC Q5F393; E1BRL1;
DT 15-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 15-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
GN Name=NCOA1 {ECO:0000313|Ensembl:ENSGALP00010014582.1};
GN ORFNames=RCJMB04_27h20 {ECO:0000313|EMBL:CAH65391.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:CAH65391.1};
RN [1] {ECO:0000313|EMBL:CAH65391.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CB {ECO:0000313|EMBL:CAH65391.1};
RC TISSUE=Bursa {ECO:0000313|EMBL:CAH65391.1};
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [2] {ECO:0000313|Ensembl:ENSGALP00010014582.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010014582.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ851757; CAH65391.1; -; mRNA.
DR RefSeq; NP_001012900.1; NM_001012882.1.
DR RefSeq; XP_015140590.1; XM_015285104.1.
DR STRING; 9031.ENSGALP00000050346; -.
DR PaxDb; 9031-ENSGALP00000026768; -.
DR Ensembl; ENSGALT00010025906.1; ENSGALP00010014582.1; ENSGALG00010010826.1.
DR GeneID; 422016; -.
DR KEGG; gga:422016; -.
DR CTD; 8648; -.
DR VEuPathDB; HostDB:geneid_422016; -.
DR GeneTree; ENSGT00950000183021; -.
DR HOGENOM; CLU_001988_0_0_1; -.
DR OMA; AQHVNIG; -.
DR OrthoDB; 4230728at2759; -.
DR Reactome; R-GGA-159418; Recycling of bile acids and salts.
DR Reactome; R-GGA-192105; Synthesis of bile acids and bile salts.
DR Reactome; R-GGA-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
DR Reactome; R-GGA-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
DR Reactome; R-GGA-211976; Endogenous sterols.
DR Reactome; R-GGA-3214847; HATs acetylate histones.
DR Reactome; R-GGA-3899300; SUMOylation of transcription cofactors.
DR Reactome; R-GGA-400206; Regulation of lipid metabolism by PPARalpha.
DR Reactome; R-GGA-9018519; Estrogen-dependent gene expression.
DR Reactome; R-GGA-9707564; Cytoprotection by HMOX1.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000016617; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IEA:Ensembl.
DR GO; GO:0016922; F:nuclear receptor binding; IBA:GO_Central.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IBA:GO_Central.
DR GO; GO:1904017; P:cellular response to Thyroglobulin triiodothyronine; IEA:Ensembl.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0000435; P:positive regulation of transcription from RNA polymerase II promoter by galactose; IEA:Ensembl.
DR GO; GO:0002155; P:regulation of thyroid hormone mediated signaling pathway; IEA:Ensembl.
DR CDD; cd18948; bHLH-PAS_NCoA1_SRC1; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 6.10.140.410; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR028819; NCOA1_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF1; NUCLEAR RECEPTOR COACTIVATOR 1; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 2.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 22..79
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 107..178
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 667..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1247
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1324..1347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1510 AA; 161987 MW; FCACDEB9186207EC CRC64;
MSGLGDSSTD PANPDSRKRK GSPCDTAQSN EKRRREQENK YLEELAELLS ANIGDIDTLS
VKPDKCKILK KTVDQIQQMK RLEQEKAADD EVQKSDISSS SQGVIEKESL GPLLLEALDG
FFFVVNREGR IVFVSENVTS YLGYNQEELM NTSVYSILHV GDHTEFVKNL LPKSLVNGVP
WPQEATRRNS HTFSCRMLIR PPDEPGTENQ EARQRYEVMQ CFTVSQPKSF KEEGEDFQSC
LICIARRLPR PAAVTPSESF VTKQDTTGKI ISIDTSSLRA AGRTGWEDLV RKCIYAFFQP
QGREPSYAKQ LFQEVMTRGT AFSPSYRFTL SDGTVLSAHT KCKLCYPSSP EVQPFIMGIH
IIDRDHGMLS PQENTNSAMA LPRVSPSLNP NISPGQGMAL PPSIPPSNGS MLATPGNQQP
GAGLHSSNSS TSQTSFGCSP GNQIGANVAL SQGQAGPPNS NHNLNLSSSP MNSPGITPPQ
FMSPRHRVSP GLVPRPRGPS NPFSPTMPTM HSPVGMANSG GGGNGGGGGG GSRSFPTAPI
NSLQGLSEGA STPVGYSTPP PVLRQLGSQS SPGRLGMQPM KAESKDSKEI ASILSEMIQS
DGSAGDGKPL DSGVLHASER LTEGESKCSQ ATSHKLVQLL ASTAEQQLRH ADADTSCKDS
LACAGTTGTL GASNPPSSTC PSSHSSLTER HKILHRLLQE GSPSDITTLA MEHDKKDNVP
NPATTPTAPS QLPGTQDIKL ESDAMKKKDV KDHQLLRYLL DKDEKELAAA PALSLDDVKV
KVEKTEQMEP CNTTPVPLAK PPAAEEVKLE SQGQFAAELE QLDQLLPSLE KAAQLPGLCG
PERSESGVAV KSEMLAAPLQ PSTAPRAPTG LNPLSSGQGM QAARAPFEFC DPLEPAQLRP
VAFPTTNGSS PRPRAPAEQG RGTVPGPNPF PPDTGMSELE MGVPDHQFGQ PGMGEQMPWT
DNSMAPMNRG TLSKPEDPCI TSQLDELLCP PTTPEGRNDE KALLEQLVSF LSGKDETELA
ELDRALGIDK LVQGGGLEAL TERFQPQQAT PPLMMEQKPG MYPQPYSSAS PTTNLPAAFP
GMVRQKPSFG PMPVQVPPPR GAFPTTMAMQ PRQALSRPPT APNQLRLQLQ QRLQGQQQLI
HQNRQAILNQ FAANSPVGIN MRAGMQQQMT PQPPLNAQML AQRQRELYSQ QHRQRQLMQQ
RAILMRQQSF GNNLPPSAGL PVQMGAARLP QAPPQQFPYP PNYGTSPGNP PTSTSPFSQL
ASSPEAALAN RGGMVTRGMM GSVGGQFGTG MTPQMQQNIF QYSGSGMGQQ NEPTFAPSLS
PSSPLMSPQL PPSQSPMLQP APPAPGYQSP DMKTWQQGAM GNSNVFSQTG QTQPAPAQQG
MYNNMSITVS MAGGNTNVQN MNPMAGQMQM NSLQMPGMNS MCSEQVNDPA LRPTGLYCNQ
LSSTDLLKTE ADGAQQVQQV QVFADVQCTV NLVGDPYLNP PAPLGAPKAA AVPPTPQGQQ
KSLLQQLLTE
//
