GenomeNet

Database: UniProt
Entry: Q5F3R7
LinkDB: Q5F3R7
Original site: Q5F3R7 
ID   DCA12_CHICK             Reviewed;         427 AA.
AC   Q5F3R7;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   23-MAY-2018, entry version 77.
DE   RecName: Full=DDB1- and CUL4-associated factor 12;
DE   AltName: Full=WD repeat-containing protein 40A;
GN   Name=DCAF12; Synonyms=WDR40A; ORFNames=RCJMB04_8j18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
RA   Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
RA   Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3
CC       ubiquitin-protein ligase complex. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat DCAF12 family. {ECO:0000305}.
DR   EMBL; AJ851583; CAH65217.1; -; mRNA.
DR   RefSeq; NP_001026615.1; NM_001031444.1.
DR   UniGene; Gga.22012; -.
DR   ProteinModelPortal; Q5F3R7; -.
DR   STRING; 9031.ENSGALP00000009301; -.
DR   PaxDb; Q5F3R7; -.
DR   Ensembl; ENSGALT00000009315; ENSGALP00000009301; ENSGALG00000005800.
DR   GeneID; 427396; -.
DR   KEGG; gga:427396; -.
DR   CTD; 25853; -.
DR   eggNOG; ENOG410IGRG; Eukaryota.
DR   eggNOG; ENOG410XTH6; LUCA.
DR   GeneTree; ENSGT00390000001132; -.
DR   HOGENOM; HOG000047356; -.
DR   HOVERGEN; HBG055605; -.
DR   InParanoid; Q5F3R7; -.
DR   KO; K11803; -.
DR   PhylomeDB; Q5F3R7; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q5F3R7; -.
DR   Proteomes; UP000000539; Chromosome Z.
DR   ExpressionAtlas; Q5F3R7; baseline and differential.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome;
KW   Repeat; Ubl conjugation pathway; WD repeat.
FT   CHAIN         1    427       DDB1- and CUL4-associated factor 12.
FT                                /FTId=PRO_0000306843.
FT   REPEAT      110    150       WD 1.
FT   REPEAT      154    192       WD 2.
FT   REPEAT      222    261       WD 3.
FT   REPEAT      310    347       WD 4.
SQ   SEQUENCE   427 AA;  47618 MW;  14EA8B57A5590DFC CRC64;
     MARKTVSRKR KAAAASAAGP GGLYGEQYGW DHSVHKRKRL PPVKRSLVYY LKEREFHLGT
     LNKVFASQWL NHRQVVCGTK CNTLFVVDVQ TGQITKIPIL KDREPGMVNQ QGCGIHAIEL
     NPSRTLLATG GDNPNSLAIY RLPTLDPVCV GDDGHKDWIF SIAWISDTMA VSGSRDGSMG
     LWEVTEDVLS KSDSRHNLSQ VPVYAHITHR ALKDIPKENT NPDNCKVRAL AFNNKNKELG
     AVSLDGYFHL WKAEHTLSKL LSTKLPYCRE NVCLAYGQEW SVYAVGSQAH VSFLDPRQPS
     HNVKSVCSKE RGSGIRSVSF YEHIITVGTG HGSLLFYDIR AQRFLDERPP RACYGQKQKL
     GGSEILKLTT GKGWLNHDET WRNYFSEINF FPNAVYTHCY DSSGTKLFVA GGPLPSGLHG
     NYAGLWS
//
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