ID Q5FHD6_EHRRG Unreviewed; 415 AA.
AC Q5FHD6;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Proline/betaine transporter {ECO:0000313|EMBL:CAI27734.1};
GN Name=proP {ECO:0000313|EMBL:CAI27734.1};
GN OrderedLocusNames=ERGA_CDS_02820 {ECO:0000313|EMBL:CAI27734.1};
OS Ehrlichia ruminantium (strain Gardel).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Ehrlichia.
OX NCBI_TaxID=302409 {ECO:0000313|EMBL:CAI27734.1, ECO:0000313|Proteomes:UP000000533};
RN [1] {ECO:0000313|EMBL:CAI27734.1, ECO:0000313|Proteomes:UP000000533}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gardel {ECO:0000313|EMBL:CAI27734.1,
RC ECO:0000313|Proteomes:UP000000533};
RX PubMed=16547041; DOI=10.1128/JB.188.7.2533-2542.2006;
RA Frutos R., Viari A., Ferraz C., Morgat A., Eychenie S., Kandassamy Y.,
RA Chantal I., Bensaid A., Coissac E., Vachiery N., Demaille J., Martinez D.;
RT "Comparative genomic analysis of three strains of Ehrlichia ruminantium
RT reveals an active process of genome size plasticity.";
RL J. Bacteriol. 188:2533-2542(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CR925677; CAI27734.1; -; Genomic_DNA.
DR RefSeq; WP_011154966.1; NC_006831.1.
DR AlphaFoldDB; Q5FHD6; -.
DR KEGG; erg:ERGA_CDS_02820; -.
DR HOGENOM; CLU_001265_39_0_5; -.
DR OrthoDB; 9783227at2; -.
DR Proteomes; UP000000533; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR43045; SHIKIMATE TRANSPORTER; 1.
DR PANTHER; PTHR43045:SF1; SHIKIMATE TRANSPORTER; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 353..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..406
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 415 AA; 47293 MW; BD7EF3993A2105D2 CRC64;
MSKFSNIKPT LSVLICAFIE CYDFMVYGNF SRIFSEMFFS HLTEEFSVVL SFMTFAIAFI
VRPFGSLLFG YIGDKFGRKL ALFSSATLLI ISLSGITFLP QVEAIGVLSP ILLIIFRILQ
GLSFAGEVGC MLLMMENVKD NRDIVFPMGA HFLISILGGA VGCFIFKLCY NFIPESQFYS
WGWRIPFFVG LIMSMLLPFL RNSIEESRQY LEYNRKQKIS KIPILDVILH HKKSCCAIVF
SVPFCNSLFY IFFVFLGIQQ KVSISLYALL ILMILISGTI FSMICRVYRP TTVALYSQIF
FMIVISPIIY FLGFDSYITY LIIAISLGMC STPLFALFML VFPVNVRQTG FSVSYSIAAG
CFGALTPVLF LWLSDILQLV TAPIFCIDFY AIVSLYSFYY LKTHEKVIEY ESVYR
//
