ID Q5FHW6_LACAC Unreviewed; 709 AA.
AC Q5FHW6;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=ATP-dependent protease {ECO:0000313|EMBL:AAV43708.1};
GN Name=clpE {ECO:0000313|EMBL:AAV43708.1};
GN OrderedLocusNames=LBA1910 {ECO:0000313|EMBL:AAV43708.1};
OS Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=272621 {ECO:0000313|Proteomes:UP000006381};
RN [1] {ECO:0000313|EMBL:AAV43708.1, ECO:0000313|Proteomes:UP000006381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700396 / NCK56 / N2 / NCFM
RC {ECO:0000313|Proteomes:UP000006381};
RX PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA Hamrick A., Cano R., Klaenhammer T.R.;
RT "Complete genome sequence of the probiotic lactic acid bacterium
RT Lactobacillus acidophilus NCFM.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
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DR EMBL; CP000033; AAV43708.1; -; Genomic_DNA.
DR RefSeq; WP_011254615.1; NC_006814.3.
DR RefSeq; YP_194739.1; NC_006814.3.
DR AlphaFoldDB; Q5FHW6; -.
DR STRING; 272621.LBA1910; -.
DR GeneID; 56943458; -.
DR KEGG; lac:LBA1910; -.
DR PATRIC; fig|272621.13.peg.1814; -.
DR eggNOG; COG0542; Bacteria.
DR HOGENOM; CLU_005070_4_3_9; -.
DR OrthoDB; 9803641at2; -.
DR BioCyc; LACI272621:G1G49-1864-MONOMER; -.
DR Proteomes; UP000006381; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS50151; UVR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:AAV43708.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:AAV43708.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006381}.
FT DOMAIN 316..351
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 24..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 312..358
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 24..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 78808 MW; 092A918ABFF98F1E CRC64;
MAYFDNDFDN LFNELNSSFF NDDFGSRRSD NNGNSGSIPM NYSSNMSSSP RTIQQNPQQP
NEKPIGVDLV EEAKNNKFDP VIGRDEQIDN VIEILSRRKK NNPVLIGPAG VGKTSIVEGL
AERIAAGNVP AKMANMHIIS VNINDMVAGS SLRGSFEERL KKVIDKAKSD PNIVLFIDEL
HNIVGAGSTD SENNNGDAAN ILKPALASGE LKLIGATTTS EFQRIEKDPA LSRRFQAVQV
PEPSTDVAIK ILEGLKKKYE DYHHVKYTDD SLKLAVELSE RYIQGRYLPD KAIDLMDEAG
AKKALLVQPT DEKSLKNQIS ALEAKKAEAA KAEDYDKAAE IKEKIASLES QLKSVDSKNT
PEVTAKDIYQ IIEQKTKIPM SELHADEAQK NLDLAKKLKK NVIDQDRAID VITDAIARKQ
IFKDSDRPTG SFLLTGPTGV GKTELAKQLA IQLFGNKEHL IRLDMSEYQD EMAVNKLIGS
APGYVGYGEG GQLTEKVRHQ PYSLILFDEI EKANPQVFNA LLQIMDDGRL TDAQGRTVSF
KDTILIMTSN AGFSDKLLED GKVDQDKLIS ALENYFRPEF LNRLDAIVPF NSLTEQDMGK
IINIYLKKMS HVLAKKGVTV EVSDEAKEFL AEKGYDKKFG ARPLRRVVEQ NLETPAAKLI
LREPDTKKIE FTADDKHLYL NGKAIFDISP KVEEKVKEDE AKAEGKKED
//
