ID Q5FJ40_LACAC Unreviewed; 639 AA.
AC Q5FJ40;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Lactose permease {ECO:0000313|EMBL:AAV43284.1};
GN Name=lacS {ECO:0000313|EMBL:AAV43284.1};
GN OrderedLocusNames=LBA1463 {ECO:0000313|EMBL:AAV43284.1};
OS Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=272621 {ECO:0000313|Proteomes:UP000006381};
RN [1] {ECO:0000313|EMBL:AAV43284.1, ECO:0000313|Proteomes:UP000006381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700396 / NCK56 / N2 / NCFM
RC {ECO:0000313|Proteomes:UP000006381};
RX PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA Hamrick A., Cano R., Klaenhammer T.R.;
RT "Complete genome sequence of the probiotic lactic acid bacterium
RT Lactobacillus acidophilus NCFM.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the sodium:galactoside symporter (TC 2.A.2)
CC family. {ECO:0000256|ARBA:ARBA00009617}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC sodium:galactoside symporter (TC 2.A.2) family.
CC {ECO:0000256|ARBA:ARBA00007724}.
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DR EMBL; CP000033; AAV43284.1; -; Genomic_DNA.
DR RefSeq; WP_011254471.1; NC_006814.3.
DR RefSeq; YP_194315.1; NC_006814.3.
DR AlphaFoldDB; Q5FJ40; -.
DR STRING; 272621.LBA1463; -.
DR GeneID; 56943038; -.
DR KEGG; lac:LBA1463; -.
DR PATRIC; fig|272621.13.peg.1385; -.
DR eggNOG; COG2190; Bacteria.
DR eggNOG; COG2211; Bacteria.
DR HOGENOM; CLU_027408_1_0_9; -.
DR OrthoDB; 9764596at2; -.
DR BioCyc; LACI272621:G1G49-1433-MONOMER; -.
DR Proteomes; UP000006381; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR CDD; cd17332; MFS_MelB_like; 1.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR039672; MFS_2.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001927; Na/Gal_symport.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR NCBIfam; TIGR00792; gph; 1.
DR NCBIfam; TIGR00830; PTBA; 1.
DR PANTHER; PTHR11328:SF24; INNER MEMBRANE SYMPORTER YICJ-RELATED; 1.
DR PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13347; MFS_2; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006381};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 321..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 504..611
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
SQ SEQUENCE 639 AA; 70054 MW; AEADC42DF8A42755 CRC64;
MANGHKTSGK QIISYASFCL GNLGHAAFYG VMSTYFIIFI TSGMFSGLEQ SVADKLIGLI
TGLMVLIRIV ELVIDPILGN IVDNTKTKWG KFKPWIFIGT MVSAVLLLIL FTGIFGLAQS
NWILFAILFV IIYIGFDVFY SLSDVSYWGM VPALSEDSHE RGIYTSLGAF SGAIGWNGLA
IIVVPLVTGV TYAVTGKNEE GAPGWLAFAA VISALAIICA IIVCFGTKEK HNLIRNSAKQ
KTTLRQVFSA IFHNDQILWP SLAYLVFSLA NTITNGVLFY LYKFVIGKPG EFWVVGLIAT
IIGFCVSPMF PILNKYIPRK WLFIAGQTCM ICAYLLFIFC RDNVVLMDLG LILFNINFAQ
LVTVLTLTDA IEYGQLKSGQ RNEAVVLAVR PMIDKFTGAV SNALVGYVAI AAGMTGTATA
ADMTAHDIST FNTMALYIPL VLPAISIVVF MTKVNLSEKK HAQVVEELKD KLAEGKLEKA
DTEAARPKEV TIYAPADGKL MNMSSVIDED GRPFPGKGFA IKPSTGKIYA PFDGEIKFTF
GTKHAFEIIS NDGLQVIVHV GLGTVNLRGQ GFETYYDDGQ HVKKGDLLLE FDRDLALNNG
YKDTIVTFYT QPRRIQETSE IQAGTTVEHG EKVVEVKFR
//
