ID Q5FLD9_LACAC Unreviewed; 626 AA.
AC Q5FLD9;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=PTS system, arbutin-like IIBC component {ECO:0000313|EMBL:AAV42485.1};
DE EC=2.7.1.69 {ECO:0000313|EMBL:AAV42485.1};
GN OrderedLocusNames=LBA0606 {ECO:0000313|EMBL:AAV42485.1};
OS Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=272621 {ECO:0000313|Proteomes:UP000006381};
RN [1] {ECO:0000313|EMBL:AAV42485.1, ECO:0000313|Proteomes:UP000006381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700396 / NCK56 / N2 / NCFM
RC {ECO:0000313|Proteomes:UP000006381};
RX PubMed=15671160; DOI=10.1073/pnas.0409188102;
RA Altermann E., Russell W.M., Azcarate-Peril M.A., Barrangou R., Buck B.L.,
RA McAuliffe O., Souther N., Dobson A., Duong T., Callanan M., Lick S.,
RA Hamrick A., Cano R., Klaenhammer T.R.;
RT "Complete genome sequence of the probiotic lactic acid bacterium
RT Lactobacillus acidophilus NCFM.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:3906-3912(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000033; AAV42485.1; -; Genomic_DNA.
DR RefSeq; WP_003546418.1; NC_006814.3.
DR RefSeq; YP_193516.1; NC_006814.3.
DR AlphaFoldDB; Q5FLD9; -.
DR STRING; 272621.LBA0606; -.
DR GeneID; 56942238; -.
DR KEGG; lac:LBA0606; -.
DR PATRIC; fig|272621.13.peg.579; -.
DR eggNOG; COG1263; Bacteria.
DR eggNOG; COG1264; Bacteria.
DR HOGENOM; CLU_012312_1_0_9; -.
DR OrthoDB; 9764327at2; -.
DR BioCyc; LACI272621:G1G49-630-MONOMER; -.
DR Proteomes; UP000006381; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0103111; F:D-glucosamine PTS permease activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00212; PTS_IIB_glc; 1.
DR Gene3D; 3.30.1360.60; Glucose permease domain IIB; 2.
DR InterPro; IPR036878; Glu_permease_IIB.
DR InterPro; IPR018113; PTrfase_EIIB_Cys.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013013; PTS_EIIC_1.
DR InterPro; IPR001996; PTS_IIB_1.
DR InterPro; IPR010975; PTS_IIBC_a_glc.
DR NCBIfam; TIGR00826; EIIB_glc; 1.
DR NCBIfam; TIGR02005; PTS-IIBC-alpha; 1.
DR PANTHER; PTHR30009; CYTOCHROME C-TYPE SYNTHESIS PROTEIN AND PTS TRANSMEMBRANE COMPONENT; 1.
DR PANTHER; PTHR30009:SF12; PHOSPHOTRANSFERASE IIC COMPONENT GLVC; 1.
DR Pfam; PF00367; PTS_EIIB; 2.
DR Pfam; PF02378; PTS_EIIC; 1.
DR SUPFAM; SSF55604; Glucose permease domain IIB; 2.
DR PROSITE; PS51098; PTS_EIIB_TYPE_1; 2.
DR PROSITE; PS01035; PTS_EIIB_TYPE_1_CYS; 1.
DR PROSITE; PS51103; PTS_EIIC_TYPE_1; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000006381};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAV42485.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..423
FT /note="PTS EIIC type-1"
FT /evidence="ECO:0000259|PROSITE:PS51103"
FT DOMAIN 454..536
FT /note="PTS EIIB type-1"
FT /evidence="ECO:0000259|PROSITE:PS51098"
FT DOMAIN 548..626
FT /note="PTS EIIB type-1"
FT /evidence="ECO:0000259|PROSITE:PS51098"
FT ACT_SITE 476
FT /note="Phosphocysteine intermediate; for EIIB activity"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
FT ACT_SITE 570
FT /note="Phosphocysteine intermediate; for EIIB activity"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00421"
SQ SEQUENCE 626 AA; 68952 MW; 04D2BC6350D653AD CRC64;
MMQKIQRFGA AMFVPVMLFS FAGIVVALGS LFNNPTLFGS IANPGTTWNS VWDTISAGGW
TVFNQEGILF TVGLPIGLAN KARGRAAMES VIAYLTYNYF IGAMLTHWGA AFGIPNFDKI
QIVANSTNHG LTNIAGIKTL DTSILAALVV ALIVVWLHNK YFDKKLPDWL GTFQGSTYVY
AISFFVMIPL ALITCWGWPK VQMGITGMQH FIVDSGFIGV WIYQFLNRVL IPTGLHHLVY
IPFQFGPAVV AGGLQPYWLK HLAEYAASTK PLSQIASVEG FQLYGNEKIF LVPFICLAFY
ATAKKNKKKQ TSALLIPAAL TSVLAGITEP IDFTYLFAAP VLWVVYSVLS ATMNTVMWAF
GLRGFMSDGA IGIASMNWLP LWEHHWQTYV MQFIVGIIFG IITYFVFKIM IEKFNYITPG
READDQDVKL INKKEYKQKM AAKAAGKDAN DPYIARATAY LDLLGGPSNI TELSSCATRL
RVSVADPSKV APDADFKANK AVNVVHHGKA LQVIVGLDVP QVLDEMTQLM QQSGNEAKVS
TEPDNPYIER ATGIVDLLGG GENIKDVIAC STRVRAHVFD PKKVAPDSEF KKIADSYEVQ
HKDNNEIDIV VGLDADQVVD QIKQLL
//
