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Database: UniProt
Entry: Q5FWR0
LinkDB: Q5FWR0
Original site: Q5FWR0 
ID   SMRCD_XENTR             Reviewed;        1003 AA.
AC   Q5FWR0; F6W182; F7CJC9;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   31-JUL-2019, entry version 79.
DE   RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1;
DE            EC=3.6.4.12;
GN   Name=smarcad1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA helicase that possesses intrinsic ATP-dependent
CC       nucleosome-remodeling activity and is both required for DNA repair
CC       and heterochromatin organization. Promotes DNA end resection of
CC       double-strand breaks (DSBs) following DNA damage: probably acts by
CC       weakening histone DNA interactions in nucleosomes flanking DSBs.
CC       Required for the restoration of heterochromatin organization after
CC       replication (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}. Note=Colocalizes with PCNA at replication forks
CC       during S phase. Recruited to double-strand breaks (DSBs) sites of
CC       DNA damage (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000305}.
DR   EMBL; AAMC01061573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01061574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01061575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC089242; AAH89242.1; -; mRNA.
DR   RefSeq; NP_001015697.1; NM_001015697.1.
DR   RefSeq; XP_017948418.1; XM_018092929.1.
DR   RefSeq; XP_017948421.1; XM_018092932.1.
DR   SMR; Q5FWR0; -.
DR   STRING; 8364.ENSXETP00000041632; -.
DR   GeneID; 548414; -.
DR   KEGG; xtr:548414; -.
DR   CTD; 56916; -.
DR   Xenbase; XB-GENE-492700; smarcad1.
DR   HOGENOM; HOG000172362; -.
DR   InParanoid; Q5FWR0; -.
DR   KO; K14439; -.
DR   OrthoDB; 61251at2759; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008094; F:DNA-dependent ATPase activity; IBA:GO_Central.
DR   GO; GO:0043044; P:ATP-dependent chromatin remodeling; ISS:UniProtKB.
DR   GO; GO:0000729; P:DNA double-strand break processing; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   InterPro; IPR009060; UBA-like_sf.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF46934; SSF46934; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51140; CUE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chromatin regulator; Chromosome; Complete proteome;
KW   DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1   1003       SWI/SNF-related matrix-associated actin-
FT                                dependent regulator of chromatin
FT                                subfamily A containing DEAD/H box 1.
FT                                /FTId=PRO_0000420486.
FT   DOMAIN      221    264       CUE. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00468}.
FT   DOMAIN      486    654       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      835    997       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     499    506       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       605    608       DEGH box.
SQ   SEQUENCE   1003 AA;  114788 MW;  9A74272E88E1784F CRC64;
     MSAFNLERFR FDKGKKIDTE FGEKGASSRP STPNSQLEDH VTSIPETPEA KRVNNPSLFK
     KDKGVSFLDS DSENEDHQSK SKFSSTHQQS HPREENGTSD SVTDDSEDDY LAVKRPSAST
     AQVKDGSKYK NLQRLKEIFP KQNNDELLKL IESTSTLDGA VAAGVVLFNK EGSSRKRKLD
     EVPKDSSPVH EGINGQTKKK KKIDRVSSDN DSSLSEDDWE KQEASVKKLQ RHFPDLDKEE
     LREVLQEHDW SFHEALEALK LFAEDETDAL QNAAKKEVSN GKEFSRSNKN DNKSSAKAKA
     NQNSNKAMAQ NGVKKKGKGK KYSENAKRDT RDLESEESAS DAGSCLDEDY SSGDEKLEEE
     YKTKILSFLQ DASLDELYLI PHCSHKKAQK ITELRPFSSW ESLFEKMTKS NGLSEDLIWD
     CQTLIKEREV VMKLMNKCEE ISRTLTKQVT QLTEDGECGW NIEQPSIMSE NLVLKPYQKI
     GLNWLALLHK HKVNMILADE MGLGKTVQAI AFLAHLYVTG DSGPHLVVVP ASTMDNWIRE
     FNQWCPSMNI LLYYGSQEER KHLRYDILNK VVEFNVIVTT YNCAISSAED RSLFRRLKLN
     FAVFDEGHML KNMSAIRYQH LMTLNARSRL LLTGTPVQNN LLELMSLLNF VMPHMFSSST
     SEIKRLFSSK AKSTDEQTIF EKERIAHAKQ IMKPFILRRV KSEVLKQLPP KQDKIKFCQM
     SKKQEQLYSD LLNKLKKSID ATEKNSELCN VMMHLRKMAN HPLLHRQYYT ADRLRTMSKL
     MLKEPTHCDA NPDLIFEDME VMTDFELHRL CNEFTTLSQY KLEKELILDS GKFNILEKLL
     SDIKKKGDRV VLFSQFTMML DIIEVFLRHH QHRYVRLDGK TQISERIHLI DEFNTDMDIF
     IFLLSTKAGG LGINLTSANI VILHDIDCNP YNDKQAEDRC HRVGQTKEVK VIKLIGKGTI
     EESMLKISQQ KLRLEQDMTT NDTGDEGTIP LDMATLLKTS LGL
//
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