ID Q5GR23_9VIRU Unreviewed; 2004 AA.
AC Q5GR23;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Replicase {ECO:0000313|EMBL:CAF04326.1};
OS Daphne virus S.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Alsuviricetes;
OC Tymovirales; Betaflexiviridae; Quinvirinae; Carlavirus.
OX NCBI_TaxID=216614 {ECO:0000313|EMBL:CAF04326.1, ECO:0000313|Proteomes:UP000202355};
RN [1] {ECO:0000313|EMBL:CAF04326.1, ECO:0000313|Proteomes:UP000202355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=type strain: K {ECO:0000313|Proteomes:UP000202355};
RX PubMed=16096707; DOI=10.1007/s00705-005-0606-x;
RA Lee B.Y., Min B.E., Ha J.H., Lee M.Y., Paek K.H., Ryu K.H.;
RT "Genome structure and complete sequence of genomic RNA of Daphne virus S.";
RL Arch. Virol. 151:193-200(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the potexviruses/carlaviruses RNA replication
CC protein family. {ECO:0000256|ARBA:ARBA00008513}.
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DR EMBL; AJ620300; CAF04326.1; -; Genomic_RNA.
DR RefSeq; YP_595727.1; NC_008020.1.
DR GeneID; 5141573; -.
DR KEGG; vg:5141573; -.
DR Proteomes; UP000202355; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016817; F:hydrolase activity, acting on acid anhydrides; IEA:InterPro.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23245; Betaflexiviridae_RdRp; 1.
DR CDD; cd22792; OTU_RDRP-like; 1.
DR Gene3D; 2.60.120.590; Alpha-ketoglutarate-dependent dioxygenase AlkB-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR InterPro; IPR037151; AlkB-like_sf.
DR InterPro; IPR002588; Alphavirus-like_MT_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008041; Peptidase_C23.
DR InterPro; IPR001788; RNA-dep_RNA_pol_alsuvir.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF05379; Peptidase_C23; 1.
DR Pfam; PF00978; RdRP_2; 1.
DR Pfam; PF01443; Viral_helicase1; 1.
DR Pfam; PF01660; Vmethyltransf; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51743; ALPHAVIRUS_MT; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
DR PROSITE; PS50802; OTU; 1.
DR PROSITE; PS51492; PEPTIDASE_C23; 1.
DR PROSITE; PS51657; PSRV_HELICASE; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000202355};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 63..254
FT /note="Alphavirus-like MT"
FT /evidence="ECO:0000259|PROSITE:PS51743"
FT DOMAIN 740..831
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 908..1017
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT DOMAIN 1016..1106
FT /note="Peptidase C23"
FT /evidence="ECO:0000259|PROSITE:PS51492"
FT DOMAIN 1158..1493
FT /note="(+)RNA virus helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51657"
FT DOMAIN 1787..1894
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 811..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2004 AA; 227590 MW; 24EC461D9CA1DB5D CRC64;
MALTYRSPME EIMTVYDTSI QGAIAGISAN HYKDCETRDF KFFCYALEPE AKKNLTNAGI
YLSPFSAMPH SHPVCKTLEN YLLYKVLPSV VDNSFLFVGM KQFKLELLKA RNSNLSMVEV
INRYVTSADR VRYDSTFVIR RSKPIGGLKR HAPGLESAPL KELVPEIMAR SAKHLFLHDE
LHYWSHRDLI TMLEVLKPDK LLGTLVYPPE LLCGSTSSLY PWCYDFEVLG KDFFFYPDGV
RSEGYLQPLK GGFLLSTSKI HLSTGEVYCV DVIQSKFAHH LVCLTKGDAI ALKFRSFGEF
AATGCKGLSP MTKGLGSFIP VSYPIISRIY RYLRSLKKPD VQSAMSKLSQ LVPEPTGIEI
KFIQDFANFV IETSTINSMI VPSRLKLFMG KWLKNLPGFI AQRFETARGV CLDDFVMSMA
PYTYTCRLTE IDWSTEYYLE LAGRCEAEFE QDVPENMDRK YLYGPEGAKD RRGAEPYTGL
AKWADGRSPV ICVHKSHLTS MMARKTIESF LCERERKVSR KRVVAELRTW LCDIRTSLIF
PITHTLEMLD DVLQVDSLIR KILMLQRRRA SLLFVDIGAL WFLSNFRGFQ LKLTNYSEAK
VLPREAGELW AVVVAEIGNG DLRKGLKRKY YYHASAHAGK QGRTQDAVQE TWSEGASSSC
GECNVQKYVS CACGVTMELK SPVETLDHLF QAPDPLRGRR AGWYSRDGHD YNYTGASHKS
LGWAAWMDEW LKVLDLDPNY YNSCLYQVYE ADATLNWHSD DESLFEKGGR IATVNLSGSA
VFHVKCMNGC RANELVGFGV FEMPADFQST HKHKLSNPSN GRESVTFRRT AQQSVTTGSE
NFSNHEGGES NQEVVDVRVA DEFTMGVERS DGSSASSSEG VKNDELIFKR HYAGVNIESG
ICHDDRMKKI IKVPGDGDCF WHCVSRVMSN ELRLTKEKAG RVDLGSESLN DALQHQMGEQ
VYAQDEAIAA TSVCFSARIN VYQPAECVLT KFIPTSGVKH EINLINEFDH FSIVEPANCC
VPRAIAAAYK RSLSEILAVI REHCDESVSS EIWNGEGVNE MHMLLLFECF DIRADVVQQG
VSTVFNEAGR VRFSFHLEDK HLTFLEKDKL ASAPSLRYER PELSLPLASQ HVLAQIASKL
TYKATELRAK VLSRSLFEGT TGVISSNLFN GRLDLMQHGE TPPKEKSRDV YCLMGTFGAG
KSTHLANFFK MNKGRMITYV SPRKVLAEDF EKRIGLERKE KGQGREAAGQ RKKLGQEHWR
VKTFEQALLE HTKIREGSCL ILDEIQLYPP GYLDLMCYLV PDRTIIAVAG DPCQSDYDNE
KDRFIFSAME ADFMVLLKDQ EYKYMVRSLR FQNQIFSGRL PSKLCIPQSA GVIEYGLYTG
VEAFGYEDVI GARNYLVSSF EEKKIIETFC VKQVNVLTFG ESTGMTFDGV NIVLTSASFG
ASERRWLTAL SRSRKIINFI NLGHFDWNAL ATCYKGRFLA SFLAGTAKVE DLLQYLPGKP
IFVDNLDGKI GKDEGIKEEK LAGDPWLKGM IDLGQTEDIE EIELEEAILQ EPWFKVHLPR
AELESIRARW EHRFKAKEHR EVRMGYLVSE QFTDEHSKQK GKELTNAATR FEAIYPRHKA
SDTVTFIMAV KKRLRFSQPA KEMGKLLEAR LYGKFLLEQF LKHVPLKKAH NPEMMAQAKA
AFELKKTSKS AATIENHANR SCRDWLIDVG LIFSKSQLCT KFDNRFRDAK AAQSIVCFQH
EVLCRFAPYI RYIEMKLNEV LPDRFYIHSG KGLEELNDWV LKHDFSGVCT ESDYEAFDAS
QDQYIVGFEL AVMEYLGLPR DLINDYIYIK THLGSKLGSF AIMRFSGEAS TFLFNTMANM
LFTFLRYEIH GNENICFAGD DMCASKRLQV KNIHAKFLSK LKLKAKVDFT SHPTFCGWNL
TKYGIYKKPQ LVLERLCIAK ETNNLINCID NYAIEVSYAY KLGELALCEM NEEEAEAMYN
CVRIIVKNKH HLKSSISDLF QEIP
//