ID Q5H4I7_XANOR Unreviewed; 314 AA.
AC Q5H4I7;
DT 01-MAR-2005, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Malonyl CoA-acyl carrier protein transacylase {ECO:0000256|ARBA:ARBA00018953, ECO:0000256|PIRNR:PIRNR000446};
DE EC=2.3.1.39 {ECO:0000256|ARBA:ARBA00013258, ECO:0000256|PIRNR:PIRNR000446};
GN Name=fabD {ECO:0000313|EMBL:AAW74134.1};
GN OrderedLocusNames=XOO0880 {ECO:0000313|EMBL:AAW74134.1};
OS Xanthomonas oryzae pv. oryzae (strain KACC10331 / KXO85).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Xanthomonas.
OX NCBI_TaxID=291331 {ECO:0000313|EMBL:AAW74134.1, ECO:0000313|Proteomes:UP000006735};
RN [1] {ECO:0000313|EMBL:AAW74134.1, ECO:0000313|Proteomes:UP000006735}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KACC10331 / KXO85 {ECO:0000313|Proteomes:UP000006735};
RX PubMed=15673718; DOI=10.1093/nar/gki206;
RA Lee B.M., Park Y.J., Park D.S., Kang H.W., Kim J.G., Song E.S., Park I.C.,
RA Yoon U.H., Hahn J.H., Koo B.S., Lee G.B., Kim H., Park H.S., Yoon K.O.,
RA Kim J.H., Jung C.H., Koh N.H., Seo J.S., Go S.J.;
RT "The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331, the
RT bacterial blight pathogen of rice.";
RL Nucleic Acids Res. 33:577-586(2005).
RN [2] {ECO:0007829|PDB:3K89}
RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS).
RA Natarajan S., Jung J.W., Kang L.W.;
RT "Structure of X. oryzae pv. oryzae KACC10331, Xoo0880(fabD) complexed with
RT glycerol.";
RL Submitted (OCT-2009) to the PDB data bank.
RN [3] {ECO:0007829|PDB:3R97}
RP X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
RA Natarajan S., Jung J.W., Kang L.W.;
RT "Crystal structure of malonyl-CoA:acyl carrier protein transacylase (FabD),
RT Xoo0880, from Xanthomonas oryzae pv. oryzae KACC10331.";
RL Submitted (MAR-2011) to the PDB data bank.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP];
CC Xref=Rhea:RHEA:41792, Rhea:RHEA-COMP:9623, Rhea:RHEA-COMP:9685,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:64479,
CC ChEBI:CHEBI:78449; EC=2.3.1.39;
CC Evidence={ECO:0000256|ARBA:ARBA00000936,
CC ECO:0000256|PIRNR:PIRNR000446};
CC -!- SIMILARITY: Belongs to the fabD family.
CC {ECO:0000256|PIRNR:PIRNR000446}.
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DR EMBL; AE013598; AAW74134.1; -; Genomic_DNA.
DR PDB; 3K89; X-ray; 1.60 A; A=1-314.
DR PDB; 3R97; X-ray; 2.30 A; A=1-314.
DR PDBsum; 3K89; -.
DR PDBsum; 3R97; -.
DR AlphaFoldDB; Q5H4I7; -.
DR SMR; Q5H4I7; -.
DR STRING; 291331.XOO0880; -.
DR KEGG; xoo:XOO0880; -.
DR HOGENOM; CLU_030558_0_1_6; -.
DR BRENDA; 2.3.1.39; 6717.
DR EvolutionaryTrace; Q5H4I7; -.
DR Proteomes; UP000006735; Chromosome.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR024925; Malonyl_CoA-ACP_transAc.
DR InterPro; IPR004410; Malonyl_CoA-ACP_transAc_FabD.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR NCBIfam; TIGR00128; fabD; 1.
DR PANTHER; PTHR42681; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42681:SF1; MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR PIRSF; PIRSF000446; Mct; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3K89, ECO:0007829|PDB:3R97};
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|PIRNR:PIRNR000446};
KW Reference proteome {ECO:0000313|Proteomes:UP000006735};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000446}.
FT DOMAIN 9..312
FT /note="Malonyl-CoA:ACP transacylase (MAT)"
FT /evidence="ECO:0000259|SMART:SM00827"
FT ACT_SITE 94
FT /evidence="ECO:0000256|PIRSR:PIRSR000446-1"
FT ACT_SITE 203
FT /evidence="ECO:0000256|PIRSR:PIRSR000446-1"
SQ SEQUENCE 314 AA; 32616 MW; 26CA4BF95F681068 CRC64;
MTESTLAFVF PGQGSQSLGM LAELSELHPQ IRETFAEASE GAGVDLWALS QGGPEEMLNR
TEYTQPALLA AGVAVWRLWT AQRGQRPALL AGHSLGEYTA LVAAGVLSLH DGAHLVRLRG
QFMQAAAPAG VGAMAAVLGA EDAVVLEVCA EAAGSQVVVP ANFNSPGQIV IGGDAAAVDR
ALALLAERGV RKAVKLAVSV PSHTPLMRDA ANQLGEAMAG LSWHAPQIPV VQNVDARVHD
GSAAIRQALV EQLYLPVQWT GCVQALASQG ITRIAECGPG KVLSGLIKRI DKSLDARPLA
TPADYAGALD AWAH
//
