ID Q5HL75_STAEQ Unreviewed; 350 AA.
AC Q5HL75;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=Alcohol dehydrogenase, zinc-containing {ECO:0000313|EMBL:AAW52989.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:AAW52989.1};
GN OrderedLocusNames=SERP2112 {ECO:0000313|EMBL:AAW52989.1};
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279 {ECO:0000313|EMBL:AAW52989.1, ECO:0000313|Proteomes:UP000000531};
RN [1] {ECO:0000313|EMBL:AAW52989.1, ECO:0000313|Proteomes:UP000000531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A {ECO:0000313|Proteomes:UP000000531};
RX PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J., Khouri H., Utterback T., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR EMBL; CP000029; AAW52989.1; -; Genomic_DNA.
DR RefSeq; WP_001832329.1; NC_002976.3.
DR AlphaFoldDB; Q5HL75; -.
DR STRING; 176279.SERP2112; -.
DR KEGG; ser:SERP2112; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_3_9; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08286; FDH_like_ADH2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AAW52989.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000531};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 26..130
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 178..305
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 350 AA; 37815 MW; 69ABF2C356824876 CRC64;
MKAYEYLKPG HAQLTDKEKP TITSSTDAII RIVKTTICGT DLHIIKGDTP EVKSHTTLGH
EGIGIIEEIG DNVNNFKVGD KVIISCISSC GKCYYCKKGI YAHCENGGGW ILGHLVNGTQ
AEYVKVPFAD NSLYHAPSNL KEDALVMLSD ILPTGYEIGV LKGKVKPGCT VAIVGAGPVG
LAALLTAQFY SPSKIIMIDL DDNRLETAKE LGATHLINSK ETETAIKKVK SLNPRGVDVA
IEAVGIPQTF DLCQNLIGVD GTIANVGVHG LPVQLDIDKL WIKNINVTTG LVSGNTTEEL
LEALKSKIIQ PEQLVTHYSK LSEIESAYDL FRNATDHKAI KLIIENDITI
//
