ID Q5HMU1_STAEQ Unreviewed; 828 AA.
AC Q5HMU1;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=SERP1537 {ECO:0000313|EMBL:AAW54906.1};
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279 {ECO:0000313|EMBL:AAW54906.1, ECO:0000313|Proteomes:UP000000531};
RN [1] {ECO:0000313|EMBL:AAW54906.1, ECO:0000313|Proteomes:UP000000531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A {ECO:0000313|Proteomes:UP000000531};
RX PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J., Khouri H., Utterback T., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR EMBL; CP000029; AAW54906.1; -; Genomic_DNA.
DR RefSeq; WP_010959222.1; NC_002976.3.
DR AlphaFoldDB; Q5HMU1; -.
DR STRING; 176279.SERP1537; -.
DR KEGG; ser:SERP1537; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_342225_0_0_9; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000000531};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..165
FT /note="Bacterial DNA polymerase III alpha subunit NTPase"
FT /evidence="ECO:0000259|Pfam:PF07733"
FT DOMAIN 189..357
FT /note="DNA polymerase III alpha subunit finger"
FT /evidence="ECO:0000259|Pfam:PF17657"
FT DOMAIN 443..529
FT /note="DNA polymerase helix-hairpin-helix motif"
FT /evidence="ECO:0000259|Pfam:PF14579"
SQ SEQUENCE 828 AA; 95115 MW; 2082D55B5CD6191A CRC64;
MDIDIDCEGS KRQRIIGALK KHYGEDRVLN VCTYGTEGAK SAIKMAARGL NIPDTEAQYL
GSFIKVERGQ QWSIKDTLYG NPDKDRKPDT QFKNEMEKYP RLLETAMKLE GLVTRRGIHA
GGVIIFNDEA YKNNAIMTAS GGDVHVTQYN LSDSEYMGGV KFDLLSVENL DRIRATLELL
SKDVLIDNTK SLRENFSDLL HPKNLDLESN EYFELASTGE INDLFQFQTE IGQTTLKRVQ
PETFEQFCAA NSLMRLQSDG EEQPIDKYIR HKNDINEWYK EMREFGLNEE EIKIMEEHLL
HDKGLNITQE NSMGLSADNR ISNFTILEQN KLRKAIAKPK GSALDQIKSL FYSKGKECGA
REVFLDYVWN VQFAMQFSYS FSLLHTTAYS VIGIQNLELN RRFPRIYWQT ACLNVDSDSI
STDSKDIDYE KIANGIGKMK ENGVTVKLPS INKSTLEFSP DVEHNAIVYG LKPVKNINNE
IVDHIIANRP YHSLDDVLTK LYDTKLITNK HLISIVKSGM LDEFGERKKI MMDVVKYITD
LKTNLTLANI KLLLEADILS ERPEYELVLL RENIKNKVLR KVQTGKSKTK HKIFKVEDTE
LYDRLIGNEA IVNVVGSYYE VDEKEFKKIF DKKTKDLKEW LKTDKPIELA NRYVLNEAWK
KHALGNYSSW EMETLSFYYH KHELYNVNKE TYDITDFKEL PVDPVVADVF KFKGREMPKY
EIVNIAGTVI AKNAPKKSVT ILATDGSVVT IKYHGNFSYY DKTSKLNGSV VEESWFKKGN
KLIFSGFRRG GQFVSKKYKD TSTSSSTKLI ESISKDGVLR YKLERDYL
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