ID Q5HQ11_STAEQ Unreviewed; 775 AA.
AC Q5HQ11;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Penicillin-binding protein 1 {ECO:0000313|EMBL:AAW54126.1};
GN Name=pbp1 {ECO:0000313|EMBL:AAW54126.1};
GN OrderedLocusNames=SERP0746 {ECO:0000313|EMBL:AAW54126.1};
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279 {ECO:0000313|EMBL:AAW54126.1, ECO:0000313|Proteomes:UP000000531};
RN [1] {ECO:0000313|EMBL:AAW54126.1, ECO:0000313|Proteomes:UP000000531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A {ECO:0000313|Proteomes:UP000000531};
RX PubMed=15774886; DOI=10.1128/JB.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J., Khouri H., Utterback T., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP000029; AAW54126.1; -; Genomic_DNA.
DR RefSeq; WP_002446225.1; NC_002976.3.
DR AlphaFoldDB; Q5HQ11; -.
DR STRING; 176279.SERP0746; -.
DR KEGG; ser:SERP0746; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_6_1_9; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR CDD; cd06576; PASTA_Pbp2x-like_1; 1.
DR CDD; cd06575; PASTA_Pbp2x-like_2; 1.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.30.70.2110; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 2.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 2.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000531};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 596..655
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 656..713
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT REGION 711..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 86353 MW; B9395893E0043694 CRC64;
MAKRKIKIKK NKIGAVLLVG LFGLLFFILV LRFSYIMITG HSNGQDLIMK ANEKYLVKNS
QQPERGKIYD RNGKVLAEDV ERYKLVAVVD KKASKESKKP RHVVDKKKTA KKLAEIIDMD
ADEIEKRLNN KKAFQIEFGQ KGTNLTYQEK EKIEKMKLPG IALYPETERF YPNGNFASHL
IGMAQKDPDT GELNGALGVE KIFNSYLNGS RGALKYIHDI WGYIAPNTKK EQQPKRGDDV
HLTIDSNIQV FVEEALDDMV ERYAPKDLFA VVMDAKTGEI LAYSQRPTFN PETGKDFGKK
WANDLYQNTY EPGSTFKTYG LAAAIQEGKF KPDEKYKSGQ RNIMGSEISD WNKTGWGRIP
MSLGFTYSSN TLMMHLQDLV GADKMKSWYE RFGFGKKTGG MFDGEAAGNI GWANELQQKT
SAFGQSTTVT PAQMIQAQSA FFNKGNMLKP WFVSSIDNPI TKKNYYSGKK EFAGKPVTQE
TANKVEEELD KVVNSKKSHA MNYRVKGYDI EGKTGTAQVA DSNGGGYVKG ENPYFVSFMG
DAPKKDPKVI VYAGMSLAQK NDQEAYEMGV SKAFKPIMEN TLKYLNVGKS SDTSSKTDYS
KVPNVQGDEV QKAEDSVNAQ SLKPITIGNG KQIKQQSVKS GTKVLPHSKV MLMTDGELTM
PDMTGWTKED VLAFEDLTKI KVSTKGNGFV TNQSISKGQI IKNKDKIEVS LSAEDTDDDQ
EKTDEDSSDK KSKKDKVDED NSNASSSSKN EKSNADSKND SDDSTNETSG SERNN
//
