ID   Q5HXX8_GLUOX            Unreviewed;       963 AA.
AC   Q5HXX8;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   SubName: Full=RND-type multidrug efflux pump, inner membrane component {ECO:0000313|EMBL:AAW59625.1};
GN   OrderedLocusNames=GOX2559 {ECO:0000313|EMBL:AAW59625.1};
OS   Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans).
OG   Plasmid pGOX1 {ECO:0000313|EMBL:AAW59625.1,
OG   ECO:0000313|Proteomes:UP000006375}.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae; Gluconobacter.
OX   NCBI_TaxID=290633 {ECO:0000313|EMBL:AAW59625.1, ECO:0000313|Proteomes:UP000006375};
RN   [1] {ECO:0000313|EMBL:AAW59625.1, ECO:0000313|Proteomes:UP000006375}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=621H {ECO:0000313|Proteomes:UP000006375};
RC   PLASMID=Plasmid pGOX1 {ECO:0000313|Proteomes:UP000006375};
RX   PubMed=15665824; DOI=10.1038/nbt1062;
RA   Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F.,
RA   Ehrenreich A., Gottschalk G., Deppenmeier U.;
RT   "Complete genome sequence of the acetic acid bacterium Gluconobacter
RT   oxydans.";
RL   Nat. Biotechnol. 23:195-200(2005).
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DR   EMBL; CP000004; AAW59625.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5HXX8; -.
DR   KEGG; gox:GOX2559; -.
DR   eggNOG; COG3696; Bacteria.
DR   HOGENOM; CLU_002755_1_2_5; -.
DR   Proteomes; UP000006375; Plasmid pGOX1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF4; SLR6043 PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius}; Plasmid {ECO:0000313|EMBL:AAW59625.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006375};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        347..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        450..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        483..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        539..558
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        870..892
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        904..934
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   963 AA;  103488 MW;  3CD9CE61944ABD84 CRC64;
     MTGRSFSLQA AIIGFSIRFR GVVIATACLL FFYGLYGLRH ASYDVFPEFI PPRVTIQTEA
     AGFTPEQVET LVSRPMEIAL TGLPGIQRVQ STSIQGLSVV NVLFATSTDI YRARQLVGEQ
     MNVVAQQLPA GVHAPTMTPL TSSAGLVLVI GLTSEQQSLM QLRTLTDWSL RPRLLALPGV
     AGVSVFGGER RSLQIQVHPD QLILHHIGLD DVLAAAQEAT GIQGAGFIDT PNQRVVLQSD
     GQALTPESLA RTVIVRSDNG AVTLGSIATV TEAPIPAFGA ASIEGKTGIV VNIWEQYGAN
     TMAVTREIEA ALTDFRPQLQ GQGITLHADL FRPANFITTA LGNATRALLL GGFLVVAVIF
     LFLFDLRTAA ICCATIPLAI LIALSLLETL GVTLNAMTLG GLAIAIGEVV DDAVIGVENV
     TRRLRENRLL VQPASTARVV LDACVEVRSA VVYATFAVII VFLPVIALPG LSGRLFAPLA
     TAYVLAVMAS LAAAVTVVPA LCAWLLATPG ETRREPPLAG WTARAYERLL ARLMRHPRFV
     IGGMILTTLI GFAALPFLES DFIPDFKEGH LIIHMTAAPG TSLEQSLKLG RQVTEKLRQL
     PEIRSVAQRV GRASLDEDTY GPHTSEFEVD LNQVDGKASR QIDARVRKAL DGFVGASFSV
     SSFLTMRVNE TLSGSSSAVA INIIGDDLDV LDIQANNIVR MLHQIHGATD VRIEAPPGVP
     ELAIRLRPAD LERWGLRSAD VLRSIHTAWQ GETVGQIYER SAAFNVMVRL DDASRNDVAS
     VGFLPLHTVH GNYVPLRAVA DIYETNGRYQ VSHLGAQRTQ TVTANVTGRS AQSFVQDART
     AIAKNIKLPL GTYVQFTSAA EAESQSRKEL FINSGLAAIA VMILLSIITQ GWRNLALILV
     NLPFAFVGGI LAIIVSGTTL TLGATVGFVT LFGITLRNSV MMISHFETLV EREHLRALLE
     IHG
//