ID Q5I921_PIG Unreviewed; 236 AA.
AC Q5I921;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE RecName: Full=Sex-determining region Y protein {ECO:0000256|ARBA:ARBA00019052, ECO:0000256|PIRNR:PIRNR037653};
GN Name=SRY {ECO:0000313|EMBL:AAW32109.1};
GN Synonyms=LOC106504154 {ECO:0000313|Ensembl:ENSSSCP00000027045.1}, Sry
GN {ECO:0000313|EMBL:ADR77538.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAW32109.1};
RN [1] {ECO:0000313|EMBL:AAW32109.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CJ1S {ECO:0000313|EMBL:AAW32108.1}, CP2S
RC {ECO:0000313|EMBL:AAW32111.1}, and CW5S {ECO:0000313|EMBL:AAW32109.1};
RA Han S.-H., Cho I.-C., Hwang J.-H., Choi Y.-L., Oh M.-Y., Lee S.-S.,
RA Ko M.-S.;
RT "Polymorphisms and breed-specific haplotypes of SRY gene in pigs (Sus
RT scrofa).";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADR77538.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bannawx29 {ECO:0000313|EMBL:ADR77538.1}, Bannaxer41
RC {ECO:0000313|EMBL:ADR77539.1}, Bannaxer42
RC {ECO:0000313|EMBL:ADR77540.1}, Baoshan43
RC {ECO:0000313|EMBL:ADR77542.1}, Chenghua02
RC {ECO:0000313|EMBL:ADR77543.1}, Chenghua03
RC {ECO:0000313|EMBL:ADR77544.1}, Dahe48 {ECO:0000313|EMBL:ADR77545.1},
RC Dahe49 {ECO:0000313|EMBL:ADR77546.1}, Dongch27
RC {ECO:0000313|EMBL:ADR77561.1}, Dongch28 {ECO:0000313|EMBL:ADR77562.1},
RC Dongshan01 {ECO:0000313|EMBL:ADR77565.1}, Dongshan04
RC {ECO:0000313|EMBL:ADR77566.1}, Dongxh48 {ECO:0000313|EMBL:ADR77567.1},
RC Dongxh54 {ECO:0000313|EMBL:ADR77568.1}, Erhual52
RC {ECO:0000313|EMBL:ADR77569.1}, Erhual54 {ECO:0000313|EMBL:ADR77570.1},
RC Hainanwb04 {ECO:0000313|EMBL:ADR77574.1}, Hainanwb06
RC {ECO:0000313|EMBL:ADR77575.1}, Hainanwb07
RC {ECO:0000313|EMBL:ADR77576.1}, Hainanwb08
RC {ECO:0000313|EMBL:ADR77577.1}, Hanjh46 {ECO:0000313|EMBL:ADR77581.1},
RC Huaizhu56 {ECO:0000313|EMBL:ADR77585.1}, Jiangklb51
RC {ECO:0000313|EMBL:ADR77586.1}, Jianli01 {ECO:0000313|EMBL:ADR77594.1},
RC Jianli02 {ECO:0000313|EMBL:ADR77595.1}, Jiaxingh24
RC {ECO:0000313|EMBL:ADR77596.1}, Jiaxingh25
RC {ECO:0000313|EMBL:ADR77597.1}, Jinhua10 {ECO:0000313|EMBL:ADR77598.1},
RC Jinhua13 {ECO:0000313|EMBL:ADR77599.1}, Jshwb01
RC {ECO:0000313|EMBL:ADR77590.1}, Jshwb02 {ECO:0000313|EMBL:ADR77591.1},
RC Jshwb03 {ECO:0000313|EMBL:ADR77592.1}, Jxiwb02
RC {ECO:0000313|EMBL:ADR77593.1}, Laiwuhei24
RC {ECO:0000313|EMBL:ADR77602.1}, Laiwuhei28
RC {ECO:0000313|EMBL:ADR77603.1}, Lantang01
RC {ECO:0000313|EMBL:ADR77606.1}, Lantang04
RC {ECO:0000313|EMBL:ADR77607.1}, Lepingh54
RC {ECO:0000313|EMBL:ADR77610.1}, Lepingh56
RC {ECO:0000313|EMBL:ADR77611.1}, Longlin16
RC {ECO:0000313|EMBL:ADR77616.1}, Nancheng25
RC {ECO:0000313|EMBL:ADR77624.1}, Nancheng26
RC {ECO:0000313|EMBL:ADR77625.1}, Neijiang06
RC {ECO:0000313|EMBL:ADR77626.1}, Neijiang10
RC {ECO:0000313|EMBL:ADR77627.1}, Ningx46 {ECO:0000313|EMBL:ADR77628.1},
RC Ningx48 {ECO:0000313|EMBL:ADR77629.1}, Qhbamei04
RC {ECO:0000313|EMBL:ADR77638.1}, Qianbeih23
RC {ECO:0000313|EMBL:ADR77634.1}, Qiandh52 {ECO:0000313|EMBL:ADR77636.1},
RC Qiandh53 {ECO:0000313|EMBL:ADR77637.1}, Qingping40
RC {ECO:0000313|EMBL:ADR77640.1}, Rongch01 {ECO:0000313|EMBL:ADR77642.1},
RC Rongch03 {ECO:0000313|EMBL:ADR77643.1}, Saba57
RC {ECO:0000313|EMBL:ADR77644.1}, Saba59 {ECO:0000313|EMBL:ADR77645.1},
RC Shanggao01 {ECO:0000313|EMBL:ADR77648.1}, Shanggao02
RC {ECO:0000313|EMBL:ADR77649.1}, Shangyuh32
RC {ECO:0000313|EMBL:ADR77650.1}, Shangyuh33
RC {ECO:0000313|EMBL:ADR77651.1}, Tongch30 {ECO:0000313|EMBL:ADR77658.1},
RC Tongch31 {ECO:0000313|EMBL:ADR77659.1}, Wannan22
RC {ECO:0000313|EMBL:ADR77661.1}, Wannan23 {ECO:0000313|EMBL:ADR77662.1},
RC Xiangzhu20 {ECO:0000313|EMBL:ADR77667.1}, Xiangzhu24
RC {ECO:0000313|EMBL:ADR77668.1}, Xingzih01
RC {ECO:0000313|EMBL:ADR77671.1}, Xingzih02
RC {ECO:0000313|EMBL:ADR77672.1}, Xmeishan39
RC {ECO:0000313|EMBL:ADR77670.1}, Xshwb01 {ECO:0000313|EMBL:ADR77673.1},
RC Xshwb02 {ECO:0000313|EMBL:ADR77674.1}, Yangxin12
RC {ECO:0000313|EMBL:ADR77675.1}, Yushan56 {ECO:0000313|EMBL:ADR77679.1},
RC Yushan57 {ECO:0000313|EMBL:ADR77680.1}, Zangzhu16
RC {ECO:0000313|EMBL:ADR77681.1}, Zangzhu18
RC {ECO:0000313|EMBL:ADR77682.1}, Zangzhu38
RC {ECO:0000313|EMBL:ADR77684.1}, and Zhejwb08
RC {ECO:0000313|EMBL:ADR77687.1};
RA Liu X.-H., Gu Z.-L., Liu R.-R., Zhao X.-B., Hu X.-X., Wu F., Ling F.,
RA Li N.;
RT "Insights into genetic structure of Sus scrofa populations: traces of human
RT activities.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ADF81071.1}
RP NUCLEOTIDE SEQUENCE.
RA Huo J.L., Zeng Y.Z.;
RT "Cloning and Sequence Analysis of SRY Gene in Banna Mini-pig Inbred Line
RT (BMIL).";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSSSCP00000027045.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000027045.1,
RC ECO:0000313|Proteomes:UP000008227};
RA Datahose;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Ensembl:ENSSSCP00000027045.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcriptional regulator that controls a genetic switch in
CC male development. It is necessary and sufficient for initiating male
CC sex determination by directing the development of supporting cell
CC precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells.
CC Involved in different aspects of gene regulation including promoter
CC activation or repression. Binds to the DNA consensus sequence 5'-
CC [AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation
CC in the minor groove and promotes DNA bending. Also involved in pre-mRNA
CC splicing (By similarity). In male adult brain involved in the
CC maintenance of motor functions of dopaminergic neurons.
CC {ECO:0000256|ARBA:ARBA00025418}.
CC -!- SUBUNIT: Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-
CC O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its
CC DNA-binding activity. The interaction with KPNB1 is sensitive to
CC dissociation by Ran in the GTP-bound form. Interaction with PARP1
CC impaired its DNA-binding activity. {ECO:0000256|ARBA:ARBA00024048}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SRY family. {ECO:0000256|ARBA:ARBA00005998,
CC ECO:0000256|PIRNR:PIRNR037653}.
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DR EMBL; AY842532; AAW32108.1; -; Genomic_DNA.
DR EMBL; AY842533; AAW32109.1; -; Genomic_DNA.
DR EMBL; AY842535; AAW32111.1; -; Genomic_DNA.
DR EMBL; GU991615; ADF81071.1; -; Genomic_DNA.
DR EMBL; GU143100; ADR77538.1; -; Genomic_DNA.
DR EMBL; GU143101; ADR77539.1; -; Genomic_DNA.
DR EMBL; GU143102; ADR77540.1; -; Genomic_DNA.
DR EMBL; GU143104; ADR77542.1; -; Genomic_DNA.
DR EMBL; GU143105; ADR77543.1; -; Genomic_DNA.
DR EMBL; GU143106; ADR77544.1; -; Genomic_DNA.
DR EMBL; GU143107; ADR77545.1; -; Genomic_DNA.
DR EMBL; GU143108; ADR77546.1; -; Genomic_DNA.
DR EMBL; GU143123; ADR77561.1; -; Genomic_DNA.
DR EMBL; GU143124; ADR77562.1; -; Genomic_DNA.
DR EMBL; GU143127; ADR77565.1; -; Genomic_DNA.
DR EMBL; GU143128; ADR77566.1; -; Genomic_DNA.
DR EMBL; GU143129; ADR77567.1; -; Genomic_DNA.
DR EMBL; GU143130; ADR77568.1; -; Genomic_DNA.
DR EMBL; GU143131; ADR77569.1; -; Genomic_DNA.
DR EMBL; GU143132; ADR77570.1; -; Genomic_DNA.
DR EMBL; GU143136; ADR77574.1; -; Genomic_DNA.
DR EMBL; GU143137; ADR77575.1; -; Genomic_DNA.
DR EMBL; GU143138; ADR77576.1; -; Genomic_DNA.
DR EMBL; GU143139; ADR77577.1; -; Genomic_DNA.
DR EMBL; GU143143; ADR77581.1; -; Genomic_DNA.
DR EMBL; GU143147; ADR77585.1; -; Genomic_DNA.
DR EMBL; GU143148; ADR77586.1; -; Genomic_DNA.
DR EMBL; GU143152; ADR77590.1; -; Genomic_DNA.
DR EMBL; GU143153; ADR77591.1; -; Genomic_DNA.
DR EMBL; GU143154; ADR77592.1; -; Genomic_DNA.
DR EMBL; GU143155; ADR77593.1; -; Genomic_DNA.
DR EMBL; GU143156; ADR77594.1; -; Genomic_DNA.
DR EMBL; GU143157; ADR77595.1; -; Genomic_DNA.
DR EMBL; GU143158; ADR77596.1; -; Genomic_DNA.
DR EMBL; GU143159; ADR77597.1; -; Genomic_DNA.
DR EMBL; GU143160; ADR77598.1; -; Genomic_DNA.
DR EMBL; GU143161; ADR77599.1; -; Genomic_DNA.
DR EMBL; GU143164; ADR77602.1; -; Genomic_DNA.
DR EMBL; GU143165; ADR77603.1; -; Genomic_DNA.
DR EMBL; GU143168; ADR77606.1; -; Genomic_DNA.
DR EMBL; GU143169; ADR77607.1; -; Genomic_DNA.
DR EMBL; GU143172; ADR77610.1; -; Genomic_DNA.
DR EMBL; GU143173; ADR77611.1; -; Genomic_DNA.
DR EMBL; GU143178; ADR77616.1; -; Genomic_DNA.
DR EMBL; GU143186; ADR77624.1; -; Genomic_DNA.
DR EMBL; GU143187; ADR77625.1; -; Genomic_DNA.
DR EMBL; GU143188; ADR77626.1; -; Genomic_DNA.
DR EMBL; GU143189; ADR77627.1; -; Genomic_DNA.
DR EMBL; GU143190; ADR77628.1; -; Genomic_DNA.
DR EMBL; GU143191; ADR77629.1; -; Genomic_DNA.
DR EMBL; GU143196; ADR77634.1; -; Genomic_DNA.
DR EMBL; GU143198; ADR77636.1; -; Genomic_DNA.
DR EMBL; GU143199; ADR77637.1; -; Genomic_DNA.
DR EMBL; GU143200; ADR77638.1; -; Genomic_DNA.
DR EMBL; GU143202; ADR77640.1; -; Genomic_DNA.
DR EMBL; GU143204; ADR77642.1; -; Genomic_DNA.
DR EMBL; GU143205; ADR77643.1; -; Genomic_DNA.
DR EMBL; GU143206; ADR77644.1; -; Genomic_DNA.
DR EMBL; GU143207; ADR77645.1; -; Genomic_DNA.
DR EMBL; GU143210; ADR77648.1; -; Genomic_DNA.
DR EMBL; GU143211; ADR77649.1; -; Genomic_DNA.
DR EMBL; GU143212; ADR77650.1; -; Genomic_DNA.
DR EMBL; GU143213; ADR77651.1; -; Genomic_DNA.
DR EMBL; GU143220; ADR77658.1; -; Genomic_DNA.
DR EMBL; GU143221; ADR77659.1; -; Genomic_DNA.
DR EMBL; GU143223; ADR77661.1; -; Genomic_DNA.
DR EMBL; GU143224; ADR77662.1; -; Genomic_DNA.
DR EMBL; GU143229; ADR77667.1; -; Genomic_DNA.
DR EMBL; GU143230; ADR77668.1; -; Genomic_DNA.
DR EMBL; GU143232; ADR77670.1; -; Genomic_DNA.
DR EMBL; GU143233; ADR77671.1; -; Genomic_DNA.
DR EMBL; GU143234; ADR77672.1; -; Genomic_DNA.
DR EMBL; GU143235; ADR77673.1; -; Genomic_DNA.
DR EMBL; GU143236; ADR77674.1; -; Genomic_DNA.
DR EMBL; GU143237; ADR77675.1; -; Genomic_DNA.
DR EMBL; GU143241; ADR77679.1; -; Genomic_DNA.
DR EMBL; GU143242; ADR77680.1; -; Genomic_DNA.
DR EMBL; GU143243; ADR77681.1; -; Genomic_DNA.
DR EMBL; GU143244; ADR77682.1; -; Genomic_DNA.
DR EMBL; GU143246; ADR77684.1; -; Genomic_DNA.
DR EMBL; GU143249; ADR77687.1; -; Genomic_DNA.
DR RefSeq; XP_013842032.1; XM_013986578.1.
DR STRING; 9823.ENSSSCP00000027045; -.
DR Ensembl; ENSSSCT00000027478.2; ENSSSCP00000027045.1; ENSSSCG00000059393.1.
DR GeneID; 106504154; -.
DR KEGG; ssc:106504154; -.
DR GeneTree; ENSGT00940000165583; -.
DR HOGENOM; CLU_1209425_0_0_1; -.
DR OMA; CALPCRE; -.
DR OrthoDB; 2902801at2759; -.
DR Proteomes; UP000008227; Chromosome Y.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0030238; P:male sex determination; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
DR CDD; cd22034; HMG-box_SoxA_SRY; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017253; SRY.
DR PANTHER; PTHR10270:SF199; SEX-DETERMINING REGION Y PROTEIN; 1.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF037653; SRY; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR037653};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|PIRNR:PIRNR037653};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037653};
KW Nucleus {ECO:0000256|PIRNR:PIRNR037653, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Sexual differentiation {ECO:0000256|ARBA:ARBA00022928,
KW ECO:0000256|PIRNR:PIRNR037653};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR037653};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR037653}.
FT DOMAIN 62..130
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 62..130
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 32..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 27132 MW; 5DB823D0A58E89E9 CRC64;
MVQSYASAMF RVLKADDYSP AAQQQNILAL GKGSSLFPTD NHSSKDGRET RGSGRESGQD
RVKRPMNAFI VWSRDQRRKV ALENPQMQNS EISKWLGCKW KMLTEAEKRP FFEEAQRLQA
VHRDKYPGYK YRPRRKGERA QNLLPAEAAV LCSQVRVEER MYPFTYTVAK AKCSGTESQL
SHSQPMNITS SLLQQEDRCN WTGLCHSRVT STRQIRADLP FHRGLQPGLS HIYFPY
//
