ID CAHM4_HUMAN Reviewed; 314 AA.
AC Q5JW98; B0QZ25; B0QZ27; B4DTQ0; Q96MK0;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 144.
DE RecName: Full=Calcium homeostasis modulator protein 4;
DE AltName: Full=Protein FAM26D;
GN Name=CALHM4 {ECO:0000312|HGNC:HGNC:21094}; Synonyms=C6orf78, FAM26D;
GN ORFNames=UNQ6481/PRO21277;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Pore-forming subunit of a voltage-gated ion channel.
CC {ECO:0000250|UniProtKB:Q8IU99}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5JW98-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JW98-2; Sequence=VSP_013817;
CC Name=3;
CC IsoId=Q5JW98-3; Sequence=VSP_018252;
CC Name=4;
CC IsoId=Q5JW98-4; Sequence=VSP_045216;
CC -!- SIMILARITY: Belongs to the CALHM family. {ECO:0000305}.
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DR EMBL; AY358252; AAQ88619.1; -; mRNA.
DR EMBL; AK056801; BAB71288.1; -; mRNA.
DR EMBL; AK300309; BAG62062.1; -; mRNA.
DR EMBL; AL121953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW48223.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW48224.1; -; Genomic_DNA.
DR EMBL; BC057769; AAH57769.2; -; mRNA.
DR CCDS; CCDS5109.1; -. [Q5JW98-2]
DR CCDS; CCDS59031.1; -. [Q5JW98-4]
DR CCDS; CCDS59032.1; -. [Q5JW98-3]
DR CCDS; CCDS93991.1; -. [Q5JW98-1]
DR RefSeq; NP_001243816.1; NM_001256887.2. [Q5JW98-3]
DR RefSeq; NP_001243817.1; NM_001256888.2. [Q5JW98-4]
DR RefSeq; NP_001243818.1; NM_001256889.2. [Q5JW98-2]
DR RefSeq; NP_694581.1; NM_153036.4. [Q5JW98-2]
DR RefSeq; XP_005266917.1; XM_005266860.3.
DR PDB; 6YTK; EM; 4.07 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-314.
DR PDB; 6YTL; EM; 3.82 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V=1-314.
DR PDB; 6YTO; EM; 4.24 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T=1-314.
DR PDB; 6YTQ; EM; 4.02 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V=1-314.
DR PDBsum; 6YTK; -.
DR PDBsum; 6YTL; -.
DR PDBsum; 6YTO; -.
DR PDBsum; 6YTQ; -.
DR AlphaFoldDB; Q5JW98; -.
DR EMDB; EMD-10917; -.
DR EMDB; EMD-10919; -.
DR EMDB; EMD-10920; -.
DR EMDB; EMD-10921; -.
DR SMR; Q5JW98; -.
DR BioGRID; 128707; 62.
DR IntAct; Q5JW98; 15.
DR STRING; 9606.ENSP00000385836; -.
DR TCDB; 1.A.84.1.5; the calcium homeostasis modulator ca(2+) channel (calhm-c) family.
DR PhosphoSitePlus; Q5JW98; -.
DR BioMuta; CALHM4; -.
DR DMDM; 67460441; -.
DR MassIVE; Q5JW98; -.
DR PaxDb; 9606-ENSP00000385836; -.
DR PeptideAtlas; Q5JW98; -.
DR ProteomicsDB; 5119; -.
DR ProteomicsDB; 63378; -. [Q5JW98-1]
DR ProteomicsDB; 63379; -. [Q5JW98-2]
DR ProteomicsDB; 63380; -. [Q5JW98-3]
DR Pumba; Q5JW98; -.
DR Antibodypedia; 19425; 5 antibodies from 4 providers.
DR DNASU; 221301; -.
DR Ensembl; ENST00000368596.4; ENSP00000357585.3; ENSG00000164451.14. [Q5JW98-1]
DR Ensembl; ENST00000368597.6; ENSP00000357586.2; ENSG00000164451.14. [Q5JW98-2]
DR Ensembl; ENST00000405399.5; ENSP00000385836.1; ENSG00000164451.14. [Q5JW98-3]
DR Ensembl; ENST00000628083.1; ENSP00000487169.1; ENSG00000164451.14. [Q5JW98-4]
DR GeneID; 221301; -.
DR KEGG; hsa:221301; -.
DR MANE-Select; ENST00000368596.4; ENSP00000357585.3; NM_001366078.2; NP_001353007.1.
DR UCSC; uc003pwz.5; human. [Q5JW98-1]
DR AGR; HGNC:21094; -.
DR CTD; 221301; -.
DR GeneCards; CALHM4; -.
DR HGNC; HGNC:21094; CALHM4.
DR HPA; ENSG00000164451; Tissue enriched (placenta).
DR neXtProt; NX_Q5JW98; -.
DR OpenTargets; ENSG00000164451; -.
DR PharmGKB; PA162387625; -.
DR VEuPathDB; HostDB:ENSG00000164451; -.
DR eggNOG; ENOG502RKQ2; Eukaryota.
DR GeneTree; ENSGT01030000234610; -.
DR HOGENOM; CLU_069286_3_1_1; -.
DR InParanoid; Q5JW98; -.
DR OMA; FRCPCQV; -.
DR OrthoDB; 2899675at2759; -.
DR PhylomeDB; Q5JW98; -.
DR PathwayCommons; Q5JW98; -.
DR SignaLink; Q5JW98; -.
DR BioGRID-ORCS; 221301; 14 hits in 1135 CRISPR screens.
DR GenomeRNAi; 221301; -.
DR Pharos; Q5JW98; Tdark.
DR PRO; PR:Q5JW98; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5JW98; Protein.
DR Bgee; ENSG00000164451; Expressed in placenta and 40 other cell types or tissues.
DR ExpressionAtlas; Q5JW98; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IBA:GO_Central.
DR InterPro; IPR029569; CALHM.
DR PANTHER; PTHR32261; CALCIUM HOMEOSTASIS MODULATOR PROTEIN; 1.
DR PANTHER; PTHR32261:SF5; CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4; 1.
DR Pfam; PF14798; Ca_hom_mod; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Ion channel; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..314
FT /note="Calcium homeostasis modulator protein 4"
FT /id="PRO_0000186724"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..186
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_013817"
FT VAR_SEQ 1..164
FT /note="MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYG
FT SAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRA
FT VIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCR -> MA
FT PRSAKETFRINPNVAANL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045216"
FT VAR_SEQ 1..143
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_018252"
SQ SEQUENCE 314 AA; 35060 MW; 2CF5DB1741A2E64E CRC64;
MCPTLNNIVS SLQRNGIFIN SLIAALTIGG QQLFSSSTFS CPCQVGKNFY YGSAFLVIPA
LILLVAGFAL RSQMWTITGE YCCSCAPPYR RISPLECKLA CLRFFSITGR AVIAPLTWLA
VTLLTGTYYE CAASEFASVD HYPMFDNVSA SKREEILAGF PCCRSAPSDV ILVRDEIALL
HRYQSQMLGW ILITLATIAA LVSCCVAKCC SPLTSLQHCY WTSHLQNERE LFEQAAEQHS
RLLMMHRIKK LFGFIPGSED VKHIRIPSCQ DWKDISVPTL LCMGDDLQGH YSFLGNRVDE
DNEEDRSRGI ELKP
//
