ID Q5K464_LACTC Unreviewed; 542 AA.
AC Q5K464;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Putative DNA endonuclease {ECO:0000313|EMBL:CAG25600.2};
GN Name=io-cox1.2 {ECO:0000313|EMBL:CAG25600.2};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OG Mitochondrion {ECO:0000313|EMBL:CAG25600.2}.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAG25600.2, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=15620687; DOI=10.1016/j.febslet.2004.10.106;
RA Talla E., Anthouard V., Bouchier C., Frangeul L., Dujon B.;
RT "The complete mitochondrial genome of the yeast Kluyveromyces
RT thermotolerans.";
RL FEBS Lett. 579:30-40(2005).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the LAGLIDADG
CC endonuclease family. {ECO:0000256|ARBA:ARBA00009332}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the heme-copper
CC respiratory oxidase family. {ECO:0000256|ARBA:ARBA00010468}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ634268; CAG25600.2; -; Genomic_DNA.
DR RefSeq; YP_184721.1; NC_006626.1.
DR AlphaFoldDB; Q5K464; -.
DR STRING; 559295.Q5K464; -.
DR GeneID; 3238979; -.
DR InParanoid; Q5K464; -.
DR Proteomes; UP000002036; Mitochondrion.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR Gene3D; 1.20.210.10; Cytochrome c oxidase-like, subunit I domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 2.
DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom.
DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf.
DR InterPro; IPR000883; Cyt_C_Oxase_1.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR004860; LAGLIDADG_2.
DR PANTHER; PTHR10422; CYTOCHROME C OXIDASE SUBUNIT 1; 1.
DR PANTHER; PTHR10422:SF18; CYTOCHROME C OXIDASE SUBUNIT 1; 1.
DR Pfam; PF00115; COX1; 1.
DR Pfam; PF00961; LAGLIDADG_1; 2.
DR PRINTS; PR01165; CYCOXIDASEI.
DR SUPFAM; SSF81442; Cytochrome c oxidase subunit I-like; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 2.
DR PROSITE; PS50855; COX1; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000313|EMBL:CAG25600.2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Intron homing {ECO:0000256|ARBA:ARBA00022886};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, ECO:0000313|EMBL:CAG25600.2};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..130
FT /note="Cytochrome oxidase subunit I profile"
FT /evidence="ECO:0000259|PROSITE:PS50855"
SQ SEQUENCE 542 AA; 63045 MW; E675C6877DB70BCA CRC64;
MVQRWLYSTN AKDIAILYFI FAIFCGMAGT AMSVIIRLEL AAPGNQYLGG NHQLFNVLVV
GHAVLMIFFL VMPALIGGFG NYLLPLMIGA SDMSFARLNN ISFWLLPPAL VCLVTSTLVE
SGAGTGWTVI MNEMMCSCKM STDAWKTLYN FIMYTLKYSI YINKLVKMFN IMGLYASVMF
NYLTTQRTNV TKLKYYMKKK YSTTNKTNKS YFNMNEWLVG MTDGDGTFNI YTNMTHNKII
FTYKISLNKK NTQLLYKIKS YLGVGSVTFD NKTNMASYLI RDKKYLLNII IPIFDEYPLL
TTKRYNYLKF KECLLISNNN LLTQNDKLLT INNIKNKTSS LDLYSDSLKK YNIYISDAWE
SIYKKWNMKE DLTYTPMNTN DGVLIYPHKD IINNINSITI NDVNNIMTKS WLIGFIEAKG
SFFITKKSSN PLRCVHSFEL TQKLDYIVMY SIKLLLNINS SIVMKSPSIS NKSNLFYKLE
TTNNSNIEYI INYFRYKNYK SVFLGMKSFE YRIWSRTYMK HKGNYMKLLQ IKNLLQKHRK
NY
//
