ID Q5K776_CRYNJ Unreviewed; 474 AA.
AC Q5K776; Q55HN6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 114.
DE SubName: Full=Mitochondrion protein, putative {ECO:0000313|EMBL:AAW47112.1};
GN OrderedLocusNames=CNN00830 {ECO:0000313|EMBL:AAW47112.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW47112.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW47112.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017356; AAW47112.1; -; Genomic_DNA.
DR RefSeq; XP_568629.1; XM_568629.1.
DR AlphaFoldDB; Q5K776; -.
DR STRING; 214684.Q5K776; -.
DR PaxDb; 214684-Q5K776; -.
DR EnsemblFungi; AAW47112; AAW47112; CNN00830.
DR GeneID; 3255394; -.
DR KEGG; cne:CNN00830; -.
DR VEuPathDB; FungiDB:CNN00830; -.
DR eggNOG; KOG2018; Eukaryota.
DR HOGENOM; CLU_013325_9_3_1; -.
DR InParanoid; Q5K776; -.
DR OMA; SLNRHSC; -.
DR OrthoDB; 10004at2759; -.
DR Proteomes; UP000002149; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0061503; F:tRNA threonylcarbamoyladenosine dehydratase; IBA:GO_Central.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0061504; P:cyclic threonylcarbamoyladenosine biosynthetic process; IBA:GO_Central.
DR CDD; cd00755; YgdL_like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR PANTHER; PTHR43267; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE; 1.
DR PANTHER; PTHR43267:SF2; TRNA THREONYLCARBAMOYLADENOSINE DEHYDRATASE 1-RELATED; 1.
DR Pfam; PF00899; ThiF; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..355
FT /note="THIF-type NAD/FAD binding fold"
FT /evidence="ECO:0000259|Pfam:PF00899"
SQ SEQUENCE 474 AA; 53563 MW; 727B72B3D1EFC61A CRC64;
MTISLPDISH RQSLILTALA AALGTTSIIL SFQALRREAR TERLKRQVGQ DVEEWERSHE
GSGMSSPDEK IERIVRKEKN WEKEFDEGLI REQLTRNYNF LGEESMGLVR KSYVVVVGCG
GVGSWCALML LRSGVGRILL IDFDLATLSS LNRHACATLE DVGTPKVIAM QKYLKKIAPW
ARIEVEIGLW RKGEGEKWLE GADWVVDAID NIDTKADLLA HCHEQGIKVF SSMGSGAKKD
PTRVQIADIS STYEDPLARS VRRRLRMAGI SSGIPVVYST ETPSEVKLLP LDEEEFKRGA
VKELQAFDDF RVRIMPVLGP LPAIFGLNIA TYILLDLAGK PLTDYMEIKN RKRVYQSLER
GLSDRETKVK GEKLQGKLPI SLEDIGFVFE ELYHGRSSLP PFEVLQKANV IRWQKNQDLS
ADNLVVMGNK DAEKHTKECL IGDRDVREVW GDEVVEFIKR KSDEARKTIA WRRA
//
