ID Q5K8D6_CRYNJ Unreviewed; 453 AA.
AC Q5K8D6; Q55MD7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Translation initiation factor eIF2B subunit beta {ECO:0000256|ARBA:ARBA00044122};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit beta {ECO:0000256|ARBA:ARBA00044228};
GN OrderedLocusNames=CNL06080 {ECO:0000313|EMBL:AAW46619.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46619.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46619.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; AE017352; AAW46619.1; -; Genomic_DNA.
DR RefSeq; XP_568136.1; XM_568136.1.
DR AlphaFoldDB; Q5K8D6; -.
DR STRING; 214684.Q5K8D6; -.
DR PaxDb; 214684-Q5K8D6; -.
DR EnsemblFungi; AAW46619; AAW46619; CNL06080.
DR GeneID; 3255013; -.
DR KEGG; cne:CNL06080; -.
DR VEuPathDB; FungiDB:CNL06080; -.
DR eggNOG; KOG1465; Eukaryota.
DR InParanoid; Q5K8D6; -.
DR OMA; SHSCAVA; -.
DR Proteomes; UP000002149; Chromosome 12.
DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR45859; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR PANTHER; PTHR45859:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000313|EMBL:AAW46619.1};
KW Protein biosynthesis {ECO:0000313|EMBL:AAW46619.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
SQ SEQUENCE 453 AA; 48421 MW; 757447B514C62739 CRC64;
MAVDSAPQMQ KSADPNARLT DTLCTSLRRR QIVGSLNVAL ATAALIQNIV RSARYNTIDE
LLALIKAVGR KLTEANPKEL AAANIIRRIL RLIREEYRAA AAAHVSSAPN SIPSTPLMGP
STPGINAPLD HYLSAAQSAT VDAQYFPTHI QMSRQTSLSN FVAMRHSRAQ MERSGALSGG
TAEGYSANTT NLFATPNGNG HGRGSSGMAT PRASVDSDEF MKHSAKLKPL LIQAIEEVVG
ELETTHEDVA KGAREHIHSS EIILTMGHSR TVEAFLKQAY KDRKFTVVVA ESAPSYLGHS
LASSLSASGI PTLLIPDSSI HALLPRVTKV ILGAHSVLAN GGLFALSGSL ACALAAKTHS
KPVVVTTGQF KFAPAWNLYH EYGAVDFQGP GAVIGEQGKG GGGGMEGVEV VDPYYDYIRP
ELVNLFVTNE GDHPPSYIYR LIKEAYDDED VEI
//
