ID Q5K8J5_CRYNJ Unreviewed; 591 AA.
AC Q5K8J5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN OrderedLocusNames=CNL05450 {ECO:0000313|EMBL:AAW46565.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46565.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46565.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Sodium-phosphate symporter. {ECO:0000256|RuleBase:RU363058}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. {ECO:0000256|RuleBase:RU363058}.
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DR EMBL; AE017352; AAW46565.2; -; Genomic_DNA.
DR RefSeq; XP_568082.1; XM_568082.1.
DR AlphaFoldDB; Q5K8J5; -.
DR STRING; 214684.Q5K8J5; -.
DR PaxDb; 214684-Q5K8J5; -.
DR EnsemblFungi; AAW46565; AAW46565; CNL05450.
DR VEuPathDB; FungiDB:CNL05450; -.
DR eggNOG; KOG2493; Eukaryota.
DR HOGENOM; CLU_015355_3_0_1; -.
DR InParanoid; Q5K8J5; -.
DR OrthoDB; 5488632at2759; -.
DR Proteomes; UP000002149; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015319; F:sodium:inorganic phosphate symporter activity; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR001204; Phos_transporter.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR PANTHER; PTHR11101:SF80; SODIUM-DEPENDENT PHOSPHATE TRANSPORTER 2; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|RuleBase:RU363058};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 48..69
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 89..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 119..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 146..170
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 191..209
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 221..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 474..493
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 560..586
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT REGION 292..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 63834 MW; 1028B6C706AB0640 CRC64;
MPVLHQWDYL FAFGVLFAAL DAYNIGANDV ANSFATSISS RSLTLRQAAM LAAICEFLGG
VLAGAQVAST IKNGIISMSA FRNNPGIELL AFVCALAASA TWLMIATRKA WPVSTTYSIV
SALAGVGVAL DGPGAVQWGW NDGKGIATIF AGFAIAPAIS AGFGATVYLI TKYAVLTRKN
PLKAGLYVSP IYFFTVAAIL TMSIVYKGAP QLKLNKLPQT TIALAIVLTG VVIAFLSVIF
WLPFVYSKVI KKDYTLRWYH FFYGPLLWRR AAPPPPPEGA RHVPDYRVYD RDDEHKEPTT
ETPTNPVSEG STEGEGAPLE TNLTVTSHEK DKDIESAPLQ SLSKGKPYAS ALEDLEKDDH
KIEGAIILPR NLWILFRYKL PKMLLHGTSV DIHAMQSHEG KGKESDRMMK MYQHAAQYDN
ETEHLYSFLQ VLTACTNSFA HGSNDLANAV GPFAAIYYVW STGTVTPSET ETPVWIFVAG
GLMLVIGLAT YGYNIMSVLG NRLTMHSPSR GFSMELGSSI TVLLASQYGI PVSTTMCITG
ATAGVGIVSG GIKSINWRAF GWIFLGWVLT VPIAGTAAGC LTGIIINAPR F
//
