ID Q5K8N2_CRYNJ Unreviewed; 524 AA.
AC Q5K8N2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Aldehyde dehydrogenase (ALDDH), putative {ECO:0000313|EMBL:AAW46532.1};
GN OrderedLocusNames=CNL05070 {ECO:0000313|EMBL:AAW46532.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46532.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46532.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR EMBL; AE017352; AAW46532.1; -; Genomic_DNA.
DR RefSeq; XP_568049.1; XM_568049.1.
DR AlphaFoldDB; Q5K8N2; -.
DR STRING; 214684.Q5K8N2; -.
DR PaxDb; 214684-Q5K8N2; -.
DR EnsemblFungi; AAW46532; AAW46532; CNL05070.
DR GeneID; 3254745; -.
DR KEGG; cne:CNL05070; -.
DR VEuPathDB; FungiDB:CNL05070; -.
DR eggNOG; KOG2450; Eukaryota.
DR HOGENOM; CLU_005391_0_1_1; -.
DR InParanoid; Q5K8N2; -.
DR OMA; WVNRYGR; -.
DR OrthoDB; 216092at2759; -.
DR Proteomes; UP000002149; Chromosome 12.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR CDD; cd07091; ALDH_F1-2_Ald2-like; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 47..512
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 287
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 524 AA; 56559 MW; 8D9C4660ACF8ED2D CRC64;
MRRTITLRHL LPLGIRSKHI MPTHAKLNVP SLGEVEVPVG LFINNEWVES TSRETFSTVN
PATGQKLLDF AHAKKEDIDK AVIAARKAFK TTWGNNVLAA ERGVLLNKLA DLMERDSDKL
AALESINSGK GIRIAREADV ADSVACIRYY AGLADKIHGQ TVSSFGKEKF VYTLHQPIGV
CGQIIPWNYP IMMWAWKIAP ALAAGCTVVM KPSELTPLSA LALCDLVKEA GIPAGVINTV
PGHGATAGDA ISRHMDIDKV AFTGSVSTGR RISIAAAESN LKKVTLELGG KSPVIVFDSA
DVEEAADWAA LAIWFNSGQD CCAGSRLYVQ EGIFDKFLAA MKKRAEACAI GQPHDEKTSF
GPLISEGQRD KVLNYIVSGK EQGARVVTGG QKWPESNDGY WIEPTILADT TPDMTIVKEE
IFGPVVVAAP FKTEEEVLEV ANDTSYGLAA AVFTNDTRQA TRVSAALDAG TVWINQYALL
HPGVPFGGFK QSGIGRELGT YGLEAYMQIK AVHNNLTQTS PWPV
//
