ID Q5K9F7_CRYNJ Unreviewed; 265 AA.
AC Q5K9F7; Q55K42;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Probable electron transfer flavoprotein subunit beta {ECO:0000256|PIRNR:PIRNR000090};
GN OrderedLocusNames=CNK02100 {ECO:0000313|EMBL:AAW46169.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46169.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46169.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC electron acceptor for several dehydrogenases, including five acyl-CoA
CC dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers
CC the electrons to the main mitochondrial respiratory chain via ETF-
CC ubiquinone oxidoreductase (ETF dehydrogenase).
CC {ECO:0000256|ARBA:ARBA00025416, ECO:0000256|PIRNR:PIRNR000090}.
CC -!- COFACTOR:
CC Name=AMP; Xref=ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|PIRNR:PIRNR000090};
CC Note=Binds 1 AMP per subunit. {ECO:0000256|PIRNR:PIRNR000090};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRNR:PIRNR000090};
CC Note=Binds 1 FAD per dimer. {ECO:0000256|PIRNR:PIRNR000090};
CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC {ECO:0000256|PIRNR:PIRNR000090}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|PIRNR:PIRNR000090}.
CC -!- SIMILARITY: Belongs to the ETF beta-subunit/FixA family.
CC {ECO:0000256|ARBA:ARBA00007557, ECO:0000256|PIRNR:PIRNR000090}.
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DR EMBL; AE017351; AAW46169.1; -; Genomic_DNA.
DR RefSeq; XP_567686.1; XM_567686.1.
DR AlphaFoldDB; Q5K9F7; -.
DR STRING; 214684.Q5K9F7; -.
DR PaxDb; 214684-Q5K9F7; -.
DR EnsemblFungi; AAW46169; AAW46169; CNK02100.
DR GeneID; 3254446; -.
DR KEGG; cne:CNK02100; -.
DR VEuPathDB; FungiDB:CNK02100; -.
DR eggNOG; KOG3180; Eukaryota.
DR HOGENOM; CLU_060196_0_0_1; -.
DR InParanoid; Q5K9F7; -.
DR OMA; EINQPRI; -.
DR OrthoDB; 5476365at2759; -.
DR Proteomes; UP000002149; Chromosome 11.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR GO; GO:0009063; P:amino acid catabolic process; IBA:GO_Central.
DR GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central.
DR CDD; cd01714; ETF_beta; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR000049; ET-Flavoprotein_bsu_CS.
DR InterPro; IPR014730; ETF_a/b_N.
DR InterPro; IPR012255; ETF_b.
DR InterPro; IPR033948; ETF_beta_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR21294; ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT; 1.
DR PANTHER; PTHR21294:SF8; ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA; 1.
DR Pfam; PF01012; ETF; 1.
DR PIRSF; PIRSF000090; Beta-ETF; 1.
DR SMART; SM00893; ETF; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR PROSITE; PS01065; ETF_BETA; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|PIRNR:PIRNR000090};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR000090};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transport {ECO:0000256|PIRNR:PIRNR000090}.
FT DOMAIN 30..228
FT /note="Electron transfer flavoprotein alpha/beta-subunit N-
FT terminal"
FT /evidence="ECO:0000259|SMART:SM00893"
SQ SEQUENCE 265 AA; 28532 MW; 2F0E8BB8F08F8102 CRC64;
MRPTLPSLIN ILVPVKRSID YAVKIRVASD GKGVDTNVKH SMNPFDEIAV EEAIRQRDKS
GEKVESITAL SIGPPKAADT IRTALAMGAD TGIHITTPEN TIVEPLSVAH AIKAIIERSE
KAGKKFDLVF MGKQAIDDDS GATGGMLAGL LGWGQASFAS KVVIEKGGRI EVTREIDGGL
EVVESKIPMV VTTDLRLNEP RYASLPNIMK AKKKKIETLK PEDLGLDFTP RLETVSVSEP
PKRKGGSKVE TVQELVAKMK EAGVL
//
