ID   Q5K9Q6_CRYNJ            Unreviewed;      1267 AA.
AC   Q5K9Q6; Q55JU5;
DT   15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=TIP120-family protein TIP120B, putative {ECO:0000313|EMBL:AAW46282.1};
GN   OrderedLocusNames=CNK01130 {ECO:0000313|EMBL:AAW46282.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46282.1, ECO:0000313|Proteomes:UP000002149};
RN   [1] {ECO:0000313|EMBL:AAW46282.1, ECO:0000313|Proteomes:UP000002149}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- SIMILARITY: Belongs to the CAND family.
CC       {ECO:0000256|ARBA:ARBA00007657}.
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DR   EMBL; AE017351; AAW46282.1; -; Genomic_DNA.
DR   RefSeq; XP_567799.1; XM_567799.1.
DR   AlphaFoldDB; Q5K9Q6; -.
DR   STRING; 214684.Q5K9Q6; -.
DR   PaxDb; 214684-Q5K9Q6; -.
DR   EnsemblFungi; AAW46282; AAW46282; CNK01130.
DR   GeneID; 3254394; -.
DR   KEGG; cne:CNK01130; -.
DR   VEuPathDB; FungiDB:CNK01130; -.
DR   eggNOG; KOG1824; Eukaryota.
DR   HOGENOM; CLU_007157_0_0_1; -.
DR   InParanoid; Q5K9Q6; -.
DR   OMA; AYIPHFQ; -.
DR   OrthoDB; 68829at2759; -.
DR   Proteomes; UP000002149; Chromosome 11.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0010265; P:SCF complex assembly; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039852; CAND1/CAND2.
DR   InterPro; IPR013932; TATA-bd_TIP120.
DR   PANTHER; PTHR12696:SF0; CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1; 1.
DR   PANTHER; PTHR12696; TIP120; 1.
DR   Pfam; PF08623; TIP120; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1090..1252
FT                   /note="TATA-binding protein interacting (TIP20)"
FT                   /evidence="ECO:0000259|Pfam:PF08623"
FT   REGION          334..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          430..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1267 AA;  137628 MW;  408278072BBA044A CRC64;
     MSRATAVPLS SQLPGLLEKM RSIDPDYRIM ALVDLNKELT RTLAPQPSST RRPDPHYTDD
     YTESQLVEMV LKLLADTNGE VKSAAVACIS LMVKKPRPSS LSKVINSLLE DVSSDNDERR
     DTSCLALKNV VLEMPLESQQ VLSDIERIVT RVFKLFTNEI HPQIASELLQ ILTDLFVRFS
     PNVASSAAIQ STALSSLIQI LDNARPAIRK RAVPTLSSLI ATSPQLFNED LEKEIVNGVG
     QGGESSRIWM GTVASLARGK SAGSIGKLVN EGKLAELILS QTKNVEDVET VEAALTALEA
     LVLRCPSEMF PYISAITQRS LVLVKYDPNY VDLEDDDDDD VDMASDAEVD DDDEYGDADY
     SDEDDDFWKI RRSSAKLLRA LISTRPDLLS ELYNSATPVL ISRFAEREES VRLEVLAAFE
     MLLKQTATSR STDLATGGRN KRKRSEGMDE DYVSDDGPIS SLQSYLPQLS KAILTQLSSK
     SVPTRQQSFS LLRQAATALG GGLDDSADPI CTAAASALRT IDSATSSSLA IATLSFLTVF
     FDTHSARTFA SHLGNLVPAI VRCMKDKLQR ISFEAFDTAS ALTKSLRPAG SSASVSGDLS
     TPIQEVFVAT TEVLGDNSVD GDVREKALAT LGSILVQSGD LFASSFSTSL PLITNRLGSE
     STASTAIVVI GQLAASSQCK GPEFEGWLLQ ILPEVVVALR RTKRGTSKNA EFTCLLNIIE
     RVGKALPVDL AEGLIIELTP VIDTPMALQT IALALTHQPS ARPTVDAQLY PKILTTLKTS
     LNPHLVDALA EFFTAYAASL NSPERAVQLV QELSNNLGSG KRDSLPDATS GGTAAWGTTA
     KCVGGVVKGE IASAGESLAL FEDVVKGKNV KETDAYLALL CIGEIGRIVN LSTKTDLFEI
     ILSFFKHDSE EVRSAAAFAA GNLAVGVPDV YVPAIITRIS AAKDESERLL LLHAIKEVIL
     HSPSAQLESL ADTLWAPLFS ATDATPASKA DSTGGDGIRN VIAACIGKLT TTVPAKFLPQ
     LQQLLYSSPS NRAIVAAAVR YTFIDTSNGY DELIAPIIVE FLSLMKDENL IVRRLSLASL
     NAALQNKPYL IVDKLDILQP LLYQETYVKK ELQREVTMGP WKVIEDDGLE NRKTAYETMY
     TLLGACFSKI DLPTFTARVL VSLSDVNEVK ILGLMLLLRL GQVSPESVIP RLDEVVESLK
     GMMKDVEVKD DTVKQDLERK AEMQRSTLRT VVPLYKSSTV QQAPAFHVFV ENLLANEKWK
     EFRDYQA
//