ID Q5KA70_CRYNJ Unreviewed; 248 AA.
AC Q5KA70; Q55LB5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Nudix hydrolase domain-containing protein {ECO:0000259|PROSITE:PS51462};
GN OrderedLocusNames=CNJ02760 {ECO:0000313|EMBL:AAW46048.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW46048.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW46048.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AE017350; AAW46048.1; -; Genomic_DNA.
DR RefSeq; XP_567565.1; XM_567565.1.
DR AlphaFoldDB; Q5KA70; -.
DR STRING; 214684.Q5KA70; -.
DR PaxDb; 214684-Q5KA70; -.
DR EnsemblFungi; AAW46048; AAW46048; CNJ02760.
DR VEuPathDB; FungiDB:CNJ02760; -.
DR eggNOG; ENOG502S254; Eukaryota.
DR HOGENOM; CLU_037162_11_0_1; -.
DR InParanoid; Q5KA70; -.
DR OMA; ESINACA; -.
DR OrthoDB; 4161489at2759; -.
DR Proteomes; UP000002149; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008413; F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042262; P:DNA protection; IBA:GO_Central.
DR CDD; cd03427; MTH1; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR43758; 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE; 1.
DR PANTHER; PTHR43758:SF2; OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 38..173
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 248 AA; 27976 MW; D1D36AC63AD7CDB3 CRC64;
MARPTIPAEF SKLPFEQLPF SSQVPVRSWA TLQNIKPWPI EYSLVFVVDR QNSQVLLGLK
RRGMGVGLYN GFGGKPEPGE SMLGCAVREL HEESGLVVNR FDLHYKGILL TSRPDPGTQQ
EKSLLRIHIY ACTSWSGDPE TTEEMEPKWI NISDLPLEKM WPEARKYVPA LMQSILQDRS
NTEMLLARVD YEYLTSVQAP TSLPPLLGLS IKFENEDGDD LPMERLSGWW MAFTTARMLS
SVTGDSGI
//
