ID Q5KAZ7_CRYNJ Unreviewed; 525 AA.
AC Q5KAZ7; Q55MM1;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=Cell division control protein, putative {ECO:0000313|EMBL:AAW45287.1};
GN OrderedLocusNames=CNI04330 {ECO:0000313|EMBL:AAW45287.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45287.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45287.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017349; AAW45287.1; -; Genomic_DNA.
DR RefSeq; XP_572594.1; XM_572594.1.
DR AlphaFoldDB; Q5KAZ7; -.
DR STRING; 214684.Q5KAZ7; -.
DR PaxDb; 214684-Q5KAZ7; -.
DR EnsemblFungi; AAW45287; AAW45287; CNI04330.
DR GeneID; 3259570; -.
DR KEGG; cne:CNI04330; -.
DR VEuPathDB; FungiDB:CNI04330; -.
DR eggNOG; KOG0305; Eukaryota.
DR HOGENOM; CLU_014831_6_0_1; -.
DR InParanoid; Q5KAZ7; -.
DR OMA; CSGACLN; -.
DR OrthoDB; 20041at2759; -.
DR Proteomes; UP000002149; Chromosome 9.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF68; FI02843P; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:AAW45287.1};
KW Cell division {ECO:0000313|EMBL:AAW45287.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 230..297
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 242..283
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 325..357
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 467..500
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 56989 MW; AB8B296618A0FACC CRC64;
MLEENTSSNL PGDVSNPFIT KPNSPKKSRG NSSTSDSTLA SLRQGMGRMD ISSKGSSIPY
TIDVRERKDS KDTRRELDRF VPARPASLSH NSHSSSTLPT LAIDSAGHTP DTSVDHSLSQ
DQSTLSLQAS LGLNSNRRIL SFQSAPPLAS HATSHLDAQR NYLLQSSASA NRGTGSHSGK
DTKKRAPPYM PERVLDAPGF EDDYYLDLID WSCANRVAIG LGDMGYVWDA ETGSVSALGS
GAEEDTNKVT SVSWSNDGAY LAIGLDTGDI EVWDVEENKK MRTMKGHLAR VPVMSWHGHV
LTSGCRDGSI YHHDVRVAKH KVMELVGHNA EVCGLAWRSD GQFLASGGND NVVNCWDGRI
GASILNDEGT PRGVAKWTKR NHTAAVKAIA WSPWQSSLLA TGGGTADKHI HFWSTSTGAR
TASLPTSTQV TSLIFSPHSK EILGTHGYPD NTLTLWTYPT LEKIWEVPAH DSRIISSALS
PDGTTVCTGA GDENLKFWKV WEVRQAKKER EEGESGRGKT AVRIR
//
