ID Q5KD73_CRYNJ Unreviewed; 277 AA.
AC Q5KD73; Q55LN6;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Protein LDOC1 {ECO:0000256|ARBA:ARBA00044088};
GN OrderedLocusNames=CNH03540 {ECO:0000313|EMBL:AAW45211.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW45211.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW45211.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: May have an important role in the development and/or
CC progression of some cancers. {ECO:0000256|ARBA:ARBA00043935}.
CC -!- SUBUNIT: Interacts with NOD2. {ECO:0000256|ARBA:ARBA00044034}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the LDOC1 family.
CC {ECO:0000256|ARBA:ARBA00043960}.
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DR EMBL; AE017348; AAW45211.2; -; Genomic_DNA.
DR RefSeq; XP_572518.1; XM_572518.1.
DR AlphaFoldDB; Q5KD73; -.
DR PaxDb; 214684-Q5KD73; -.
DR EnsemblFungi; AAW45211; AAW45211; CNH03540.
DR VEuPathDB; FungiDB:CNH03540; -.
DR eggNOG; KOG3105; Eukaryota.
DR HOGENOM; CLU_844729_0_0_1; -.
DR InParanoid; Q5KD73; -.
DR OrthoDB; 1470048at2759; -.
DR Proteomes; UP000002149; Chromosome 8.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR032549; DUF4939.
DR InterPro; IPR032567; LDOC1-rel.
DR PANTHER; PTHR15503:SF22; CCHC-TYPE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR15503; LDOC1 RELATED; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF16297; DUF4939; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 31..112
FT /note="DUF4939"
FT /evidence="ECO:0000259|Pfam:PF16297"
FT DOMAIN 138..219
FT /note="DDE-1"
FT /evidence="ECO:0000259|Pfam:PF03184"
FT REGION 8..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 277 AA; 31650 MW; 6E482F463108DACF CRC64;
MLEILERFST NTTSITTNSR APETRHLAKE PDSFSGNPTE LENFLTSCVL YMDCYPGTFN
SDKAKINFII SHCRHKVMKS LRPLMNRAQQ PELLQNYEEF LKYLRRHWGD PDEKWNAKRE
IRNRQERRYL SGYKDPGGLT NITLRFFKPN LPAHVQPMDA GIISAFKSRY RAKVIPFALA
NYEDGVPPHL CYKVDIKSAM EMADDSWNEI TGETVENCWK KVLHVLNLGP ASLRKNSQYG
APTTAQRSKA TASSIATIMY ASSIVNGIAK ITPRDFH
//
