ID Q5KDJ5_CRYNJ Unreviewed; 427 AA.
AC Q5KDJ5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Saccharopine dehydrogenase NADP binding domain-containing protein {ECO:0000259|Pfam:PF03435};
GN OrderedLocusNames=CNG03750 {ECO:0000313|EMBL:AAW44773.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44773.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44773.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE017347; AAW44773.1; -; Genomic_DNA.
DR RefSeq; XP_572080.1; XM_572080.1.
DR AlphaFoldDB; Q5KDJ5; -.
DR PaxDb; 214684-Q5KDJ5; -.
DR EnsemblFungi; AAW44773; AAW44773; CNG03750.
DR GeneID; 3258888; -.
DR KEGG; cne:CNG03750; -.
DR VEuPathDB; FungiDB:CNG03750; -.
DR eggNOG; KOG2733; Eukaryota.
DR HOGENOM; CLU_031002_0_1_1; -.
DR InParanoid; Q5KDJ5; -.
DR OMA; GPYQLYG; -.
DR OrthoDB; 5479972at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009247; P:glycolipid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 279..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..136
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 427 AA; 46218 MW; BF170FDA4B336026 CRC64;
MAQTTKPVLV IYGATAYTAQ QLFTYLEEHP EAGDFDFILA GRNQTKLDKL NGSLKIQREV
IACELSDEEG VEAMVKRGNV IVNFAGPYRW HNAEAIIRAC SKAGKHYIDL CGESAWLAKD
IIPKYHSIAS STGACIVPSC GFDSVPSDLI VHLANQTLQT VRPGSTLADS TSIFKVKGTI
SGGTVQSMIT LTELPKEERR AGEFTLCPGI QLPSTPPALT FSLPSTPLTP ARFASFFFMY
VYNRTVVRRS QFLSGALSTK SGGKVMKYAE GLDIGYGKFG SALATIGMMV FGGLFFGFKC
LRNIILRYLP KQGEGAPLEQ LKAGHYQVTN LSTEESSAPD HKPVKILTRF DGEGDPGYLN
TCYLLAESAL ALVLPAPKGT SRPPLAKAGG LLTPATAMGD VLIERLRKSG KFQITSEVLS
EEKKKDI
//