ID Q5KDK2_CRYNJ Unreviewed; 287 AA.
AC Q5KDK2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=DNA polymerase epsilon subunit C {ECO:0000256|ARBA:ARBA00044103};
DE AltName: Full=DNA polymerase II subunit C {ECO:0000256|ARBA:ARBA00044272};
GN OrderedLocusNames=CNG03660 {ECO:0000313|EMBL:AAW44766.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44766.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44766.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AE017347; AAW44766.2; -; Genomic_DNA.
DR RefSeq; XP_572073.1; XM_572073.1.
DR AlphaFoldDB; Q5KDK2; -.
DR STRING; 214684.Q5KDK2; -.
DR PaxDb; 214684-Q5KDK2; -.
DR EnsemblFungi; AAW44766; AAW44766; CNG03660.
DR VEuPathDB; FungiDB:CNG03660; -.
DR eggNOG; KOG1657; Eukaryota.
DR HOGENOM; CLU_973231_0_0_1; -.
DR InParanoid; Q5KDK2; -.
DR OrthoDB; 11291at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0008623; C:CHRAC; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR10252:SF54; CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1; 1.
DR PANTHER; PTHR10252; HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 75..138
FT /note="Transcription factor CBF/NF-Y/archaeal histone"
FT /evidence="ECO:0000259|Pfam:PF00808"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 31701 MW; A3D68F2F51C0E037 CRC64;
MQVEYESSPA VEQPSFEEGM SFRPGSPQAG GAESEEEQDE EDVDAGEGSG AKKPARKRII
KQRQSLAEKQ PGTTMFPAAR VKKIVKADRD IDIMSSEAVF MVSVAAEYFI KHFMEEGYTK
ARLEKRKLIN YRDMANVVAR SEEFDFLKDV IPTPMPLSEA IEKRKRKVVA EENLDEDAPA
SSHLNDEDLP PLVPSTNPAF PNAIVKKPSN THAKGASAAK MKADAPTSEK EELRSVVSNA
QGTRKSARRS TMGAEDEADK SYLNELREEG ADEEAITSDG DEKMDEE
//
