ID Q5KDP5_CRYNJ Unreviewed; 1220 AA.
AC Q5KDP5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE SubName: Full=Sterol 3-beta-glucosyltransferase, putative {ECO:0000313|EMBL:AAW44734.1};
GN OrderedLocusNames=CNG03260 {ECO:0000313|EMBL:AAW44734.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44734.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44734.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017347; AAW44734.1; -; Genomic_DNA.
DR RefSeq; XP_572041.1; XM_572041.1.
DR AlphaFoldDB; Q5KDP5; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR PaxDb; 214684-Q5KDP5; -.
DR EnsemblFungi; AAW44734; AAW44734; CNG03260.
DR GeneID; 3258742; -.
DR KEGG; cne:CNG03260; -.
DR VEuPathDB; FungiDB:CNG03260; -.
DR eggNOG; KOG1192; Eukaryota.
DR HOGENOM; CLU_000537_6_0_1; -.
DR InParanoid; Q5KDP5; -.
DR OMA; MPWTKTS; -.
DR OrthoDB; 76239at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0016906; F:sterol 3-beta-glucosyltransferase activity; IEA:UniProt.
DR GO; GO:0008194; F:UDP-glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030259; P:lipid glycosylation; IEA:InterPro.
DR GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR004276; GlycoTrans_28_N.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48050; STEROL 3-BETA-GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR48050:SF26; STEROL 3-BETA-GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF03033; Glyco_transf_28; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 279..381
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 83..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1220 AA; 135514 MW; 8B1B3850A60E7C0F CRC64;
MRWFSPSEAV QRSGTPCAAQ LFDLFKYMAG DNSDGDFGQG EAAEGEENEV LPNFLPQGDR
PSPVTWDDRP YALADDPHLH IASQETRPST PSRVKHEKGT STYLEEAEKA TERERNSLSA
RLTAMSLSNL SNAMLLRSGK KVKRRPLPLK DQDPSPEIGA KSSILLTPSA SLDDYKIGVL
GDLSENDMPL DGDDITDEEK IAAIISEFGD ITSLYEDQEP ERILAESKGS VFKSVMMIGN
LHLTTHRLLF HASIPPDYGS GALSSTGSAT NDATVRQPDV LQAGPVTVHY PGAIRPSRRV
WMELSSEMVT TYPGADEASR VRPLRCVLLS SVRQLEPIDP EHPRDFYVEY ETATGWKRSH
ISVDTEQSAG QWRRAFHAAL FRQMRYKWRQ SSGFIPPDDN WSMMRVCIPL SRVTLKGISS
YHSFATLMGL DVDLDVVLHP AFSFLSSIEN RIPDAPHKLK LIHPSSISSV KPPALPCSKT
TSRKSSLWRG DADAARSPDL WNGSQANPDN PKEQKLLEFN IAVLNEQVWF AEALQSAVNA
SKLRKYAATA KEPKIVLEVD GHDCLAADDE LDSKSLGTTG STELDEDEDS GDDVLQQTRK
REKAFMAAKV FGLKEEDGIW MKRCYIVTSF LPARGHIIIT PQYICFWRRV AVGTDIRYRF
PVEDVENVFI VPGIRVRFHG LALQIKGHED LRFEFWKHSS RDEVMAHIKS LAGTSSGVTA
LSSKSPSART SNSGKQVMAV SSKQTFAVHP ADILAPSKSS LFQPLSVTDD SLPYLPFVAN
SPNFTARLEP RTFVCLTIGS RGDVQPYIAL GLQLKKDGHK VVIVTHLEFK EWVEGYGIEH
REAGGDPTAL MKLSQEHKMF SPGFFKESLG SFRQWLDNLL LDSWQACKDA DVLIESPSAM
AGIHIAEALK IPYFRAFTMP WTRTSAYPQA FLVPTFEMGP SFNYATYVLF DNIMWKATAP
QINRWRKKHL NLKPTDLSTL SITNVPFLYN FSPSVVPKPL DWHDDVIVTG YWNLEDSDRD
WVPPAALEEF IVRANEKGRP LVYIGFGSIV VPQPDEMTRS IIKAVEKANV CAIIAKGWSS
RGGDPAKEGQ NITFPESCYG IDKIPHAWLF PRVRAALHHG GAGTVGASLR AGIPTLIKPW
FGDQFFWSIR VSKLGVGLKV PSLRSDDVAS ALIKATSDRL MIEKAARIGE RIRSENGVAT
AVSAISYNIS RAANNRRTAR
//
