ID Q5KDX5_CRYNJ Unreviewed; 347 AA.
AC Q5KDX5; Q55PI2;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Activator 1 40 kDa subunit, putative {ECO:0000313|EMBL:AAW44676.1};
GN OrderedLocusNames=CNG02470 {ECO:0000313|EMBL:AAW44676.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW44676.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW44676.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the activator 1 small subunits family.
CC {ECO:0000256|ARBA:ARBA00005378}.
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DR EMBL; AE017347; AAW44676.1; -; Genomic_DNA.
DR RefSeq; XP_571983.1; XM_571983.1.
DR AlphaFoldDB; Q5KDX5; -.
DR STRING; 214684.Q5KDX5; -.
DR PaxDb; 214684-Q5KDX5; -.
DR EnsemblFungi; AAW44676; AAW44676; CNG02470.
DR GeneID; 3258699; -.
DR KEGG; cne:CNG02470; -.
DR VEuPathDB; FungiDB:CNG02470; -.
DR eggNOG; KOG0991; Eukaryota.
DR HOGENOM; CLU_042324_0_1_1; -.
DR InParanoid; Q5KDX5; -.
DR OMA; SCNYSSQ; -.
DR OrthoDB; 275853at2759; -.
DR Proteomes; UP000002149; Chromosome 7.
DR GO; GO:0031390; C:Ctf18 RFC-like complex; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR GO; GO:0031391; C:Elg1 RFC-like complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0031389; C:Rad17 RFC-like complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:EnsemblFungi.
DR GO; GO:0090618; P:DNA clamp unloading; IEA:EnsemblFungi.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:0006272; P:leading strand elongation; IEA:EnsemblFungi.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:EnsemblFungi.
DR GO; GO:0070914; P:UV-damage excision repair; IEA:EnsemblFungi.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR013748; Rep_factorC_C.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR PANTHER; PTHR11669:SF5; REPLICATION FACTOR C SUBUNIT 2; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF08542; Rep_fac_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 58..184
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
SQ SEQUENCE 347 AA; 38600 MW; EA936184C42E408A CRC64;
MASGSSSNNK LISATAKHTD AEGYEMPWVE KYRPVLLDDI VGNSDTVDRL KVIAEDGNVP
HIIISGMPGI GKTTSIHCLA HALLGEAYKE GVLELNASDE RGIDVVRNKI KSFAQRKVTL
PPGRHKIIIL DEADSMTAGA QQALRRTMEI YSNTTRFALA CNMSNKIIEP IQSRCAILRY
SKLNDAEVLK RLKEICDMES IKHNDEGLAA LIFTAEGDMR QAINNLQSTW SGFGFVNQDN
VFKICDQPHP IVIRQMIKDC QHGKIDEALA RVNALWDQGY SAVDIVVTVF RVVKGMEELP
EYLKLEFIRE IGWTHMRVLE GVGTLVQLGA MIARLSKFTL PPNALKI
//
