ID Q5KFX7_CRYNJ Unreviewed; 1690 AA.
AC Q5KFX7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN OrderedLocusNames=CNF00230 {ECO:0000313|EMBL:AAW43987.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43987.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43987.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017346; AAW43987.2; -; Genomic_DNA.
DR RefSeq; XP_571294.1; XM_571294.1.
DR STRING; 214684.Q5KFX7; -.
DR PaxDb; 214684-Q5KFX7; -.
DR EnsemblFungi; AAW43987; AAW43987; CNF00230.
DR VEuPathDB; FungiDB:CNF00230; -.
DR eggNOG; KOG3519; Eukaryota.
DR HOGENOM; CLU_240982_0_0_1; -.
DR InParanoid; Q5KFX7; -.
DR OrthoDB; 663280at2759; -.
DR Proteomes; UP000002149; Chromosome 6.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13246; PH_Scd1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF15411; PH_10; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 757..813
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..116
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..951
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1690 AA; 183381 MW; 930AE9A314579923 CRC64;
MIWPVNIPQM VNGNDSGSPS SSIEEVSQEE EVGIYGKETI MISFETDSGV CSGSEEGSRE
FATSSQASLT TQSSDSSLIF IFPPTHPSHT SNTPKKFQPP FPSSVHEPPP TFRHPPLPLT
AIGHRHRQKH RLSVSYLDFT PSIETAQALH ASASYSSNDP TTTALSAQAL IAQAKRARTK
SIRKRRSSAP SLSSPSTVRR SNTSSSIIST ISMPRASPFG PCESAINNGE SPPASPHTPV
SPTRSNGREP GSPWRGLRRA LSLSSRESSN AKRGSSRTSV LAKDEACKVS GGDRRDGEGQ
SLGSIVQRPQ DSGERSFIGP SSPTMSTAEE WGDLGTLPRF PRPPSNGNRR RKSVRGLAGL
GPPLLLLPKE GGEGDSSSSD SEGEEGRKTY ARSPSRGLPS TPPSADSQSS QESCLPPQTP
ITDTSPSLPS SLLPPILLTP NTPTAPNTHT PPSANKKLLK LLSPETVSAV VDKHHASQRT
IGDFQSTSLP AVENNSDPQV KLLHSAMPRG WQGSSPIPLP PSSQPSQHRL QPSVPYSTRT
FPSSFSSQND TADTIAISPP QSYANSSIAS PNSRSTAASG SSGSSVCSYT TVGSSLPSHQ
QWHIAERSAI ATVVEEDNTV IEEIRDEFIT KPLDVKRRSP LTQSASTNSV NRSKPTSNYF
SRERSNSQHE TINSAHSKQS SQSSHPFASF SQPASLPTAK ETFLSPQAPR RLERFDSSVI
NSSRSSPNLA GTYKMTQSVQ QLALVSTEDD RDGDVTCPVC VEPMGFTYRL PGEKPPIVPE
CGHALHEECF THVYGEVPPE GSRKVLGVCG VCRQPMKLAD GAAKKDKLSA IMGQSGKSSR
PAPSIRGTSG RGITPLTPPD PTADDPIDNS RPSVSNGQLP KVIVPTLSIK SEFSTISKNR
KGKQMITAMV IIDVPPAPDR GKYPAATRQL DEGRFSPQPS PSPTSARELA TSPSLREFNT
SDPFAHVLQD LKNRVVDLKQ LSVDSLGQLR LFDILTVRKG SLTRDFQVYL FQDALVCAAE
EKKSGFRQMF SSSNSMRSDH SGHSSKSVLK LKGRIYLRHV SRVLDQSTPS ELNLVILMED
KSLESFILTF KDRGSHETWR ATINRLIEDN GGLKERAGKI LGSGAPRSTS SGLAISFSDL
TSPTSASYTI TPATSNFTPV SPKDQSSGDL AYNVPLAPIH TPIDLVLVLS LPAFTPGQSI
PLKIKLMRSS LEFLLALLGP KDRISLVSCE MGVNGTLRKT PFLSTTRYES RKRLETFVET
LGTGKLEKDE FEVSVGSDEK LDVVTAMNVG LDVVLQRKAK NPISSMVIVS DTTDIIKRTQ
MDLVAARLDA ANILVHAVGY GRSHDPSPLW IVTNHTLGTY SFVKEWYHLR ETLAGIVGGM
MNVAMDNAKV HVSCVENDFR IMRVQGTTQA VVTGTGKDID IELQVLRYGD SREILIELEL
ENRDESQKYS DEGSNESGDG SDPASQRGGS PRRAPSSNLG IDMLSVAHSS YDEAIDEVPI
CEVDLAFRDP AAGRSVFRLP HPQLLTVAVI PRTPSSTSPA DPAILRRRME LLASDMLTRA
LLIASRKNYV QADRILRETK RIIETMQDNM RQHVSENASS RRGRSKREVQ AIMAVEGLEG
PLHDLEALLD GMEEQKGVFD RDCRNFTAQQ SGVLRSQRAW TTRSLSERTY CATGVQNIIQ
MSAEWQSRFQ
//
