ID Q5KGI0_CRYNJ Unreviewed; 2006 AA.
AC Q5KGI0; Q55S28;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 24-JAN-2024, entry version 96.
DE SubName: Full=Negative regulator of mitosis, putative {ECO:0000313|EMBL:AAW43613.2};
GN OrderedLocusNames=CNE03530 {ECO:0000313|EMBL:AAW43613.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43613.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43613.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the APC1 family.
CC {ECO:0000256|ARBA:ARBA00010547}.
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DR EMBL; AE017345; AAW43613.2; -; Genomic_DNA.
DR RefSeq; XP_570920.1; XM_570920.1.
DR STRING; 214684.Q5KGI0; -.
DR PaxDb; 214684-Q5KGI0; -.
DR EnsemblFungi; AAW43613; AAW43613; CNE03530.
DR VEuPathDB; FungiDB:CNE03530; -.
DR eggNOG; KOG1858; Eukaryota.
DR HOGENOM; CLU_001202_3_0_1; -.
DR InParanoid; Q5KGI0; -.
DR OrthoDB; 180933at2759; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR024990; Apc1.
DR InterPro; IPR048971; Apc1_3rd.
DR InterPro; IPR041221; APC1_C.
DR InterPro; IPR049255; Apc1_N.
DR InterPro; IPR011989; ARM-like.
DR PANTHER; PTHR12827:SF3; ANAPHASE-PROMOTING COMPLEX SUBUNIT 1; 1.
DR PANTHER; PTHR12827; MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER; 1.
DR Pfam; PF12859; ANAPC1; 1.
DR Pfam; PF21282; APC1_3rd; 1.
DR Pfam; PF18122; APC1_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 69..733
FT /note="Anaphase-promoting complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12859"
FT DOMAIN 1641..1721
FT /note="Anaphase-promoting complex subunit 1 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF21282"
FT DOMAIN 1770..1939
FT /note="Anaphase-promoting complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18122"
FT REGION 355..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2006 AA; 223402 MW; 72CF90263AA07F39 CRC64;
MLEASLLGPA SSPGQLLSSR SFAGPSCDLL RSSFPVIFPA HDTYDANEQS QNEKPKGRII
AAIGKESGRS DEWGEEELVW YDKTVVWSRG VELFRRFTFE HESEVVAYAC FAWFKSEGGQ
NSLSKHNNVL ARSSAASETF GPFHRSQHMA WGGPRSSSQP QSQQPQLERT LVIFLQTRAH
VYYQSGEDIT VYLPFNVDCA WGLPDGGVLI QRELEKRELR MMNKDKRKAG SVLRGMDDQS
SMSVLDDLID LEDESGPSLP RLYILENPFD ELKVAVQGQV EGGYGSKPFL SSPAQPLGAT
SSVLYVSSEP YPFVITYNQE SGEFVIYRHV RIHAAPEHPL STPDPRTMRP EELLRQPDNH
QLPVQPRHRR PSLHRNTSSF GPTAGDRRLS SAADPLDRTQ RRAPRLSRGP LPDTASTDEL
QAVLEPPSNI PANSVGHRRS RGVSLMPTMT PRPSFPENKR RASTAASFIL HDLNAPQAKM
ALHVAAEKDL RETTMMMGLE RDEVGIRSEV VFHALATWKQ PFTVDLKQIN VFLSDNEDPR
HVVINIHITS LSTLQNTSSQ LCSFDATFRT GHSQRWVIKS LPPIPCRSAI PILCSRAPVF
TSSPRQNIYD TIILPLGDGS DPQLVTIGRR QYPFSLSTKL SKSYRSSLKP IKFVDPVGPR
FTTVYANGES MRFSAAIYIR HELTQRCLEA LSGILNENAF VEFKVELLSE LLALPSCQRD
DPDAVWNVFE ETLTCMSGLQ VERRTFSTMG RIVQDSALSV DAVTRRLAAR LKSKEVHLSS
PSEYQQASFK TSIYQSLPGI LLSLHLIAQD FRLSLSRRKD LSRVVKLIIK FALQIGNRDW
VDYWERIMPV EIPNHVRVRG RALDTHILDQ FDTPPDIMLS LSRHLACPTK RFPIPGRLFK
SSGRNINSAH TFKEYPDEFD LLEPCPRIAL ITSIYRELGP SIGSRPQNLP LPRRARNALK
VIISKVPNAE WLHDLPYGVS LPILEILRAC QCSPEDDWTR EMYMLIGRPD MAMKAMKDTW
YEDLTKDDWP SGLGPERLPT IGQIMSQHQA GKMDAKTKKK APLILPHVRF GTDRRLQEVE
RIMQTTKLRI VSLSEPKGAS ADDVARYQQS FVNTLANRTL SITVGQGMFE YGTRVTTITD
VWEIPFIELS VKITPGNNVL KAEIVSDSAE WPCFHNGVAA GLSISPDCKG IDSSWIVFNR
PQALNSEHGG FLLGLGLTGH LRSLLTYHAF PLMEPRHDFT SVGLLLGLAS SYAGSGDLLI
TKILSLHTHA LLPLGSMELN ASPIIQSTAL VGLGLVYVGS RNLRMAEVAL SEVGRLDMPN
VQGFGEHQES YSFSASIAYG LIMLGRGGST TSEIDRKMLA QLRRCIVGDI TSLDSSKGRS
SFPGVDINIT APGATLALGL AYLKTMRKDV ADLLDIPQTA FSLDQVKPEW LLLRTFARAL
IMWDSVVPTI AWVEAQIPAF ILLAIKDAKQ TRSPDLTTEL AYLNILSGAG LAIGLKYAGT
ATELAHNTIM SLYATLAKAV SGQGMNYEGR IKRTSARQGL NVITIALAAV MSGTGELGVL
RRLRVSHGQE GAGVNYGTHM AMHMALGLLF LGRGQYTLGN SNLAIAAMAI AFFPRFLPNP
SDNKAYPQAF RHLWALAVEA RCLTARDVET LETVYLPVKL RFREGSSVRQ QSLISPTQLP
SFDRLLTIEV DSPRYWPIRI DLSNPRDMEN LIRTRTIYVK RKAGFIDYNS DPKGNRSIFV
RVGSMTGIDL HYDLISSGAP PSVAQEEVSE LVRIHSGDAS LVGLANHFTD VSDDFGSGIG
TFLRTVIIEC LALDKPHLIG VYLEIYLSLR REAARSRDPV LSSSEIFDGM EDIVQSGLIK
SFYDEHYEKN FAQVNAAGEK RFALVRHSFI NAARRSVLES SSEETEESHR AIEYMLKGLS
AWESDARKIA KWLARNGVPP LPLLEALKQR LYRKGLAGTE IELKMRRSAE KYWDSVVKSY
DEGPAPVYKG DVWKLCSVQQ IIDLWQ
//
