ID Q5KGM3_CRYNJ Unreviewed; 336 AA.
AC Q5KGM3;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha {ECO:0000256|ARBA:ARBA00040965};
DE EC=2.5.1.58 {ECO:0000256|ARBA:ARBA00012702};
DE EC=2.5.1.59 {ECO:0000256|ARBA:ARBA00012700};
DE AltName: Full=CAAX farnesyltransferase subunit alpha {ECO:0000256|ARBA:ARBA00043086};
DE AltName: Full=FTase-alpha {ECO:0000256|ARBA:ARBA00042436};
DE AltName: Full=Ras proteins prenyltransferase subunit alpha {ECO:0000256|ARBA:ARBA00041392};
DE AltName: Full=Type I protein geranyl-geranyltransferase subunit alpha {ECO:0000256|ARBA:ARBA00043219};
GN OrderedLocusNames=CNE03110 {ECO:0000313|EMBL:AAW43554.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43554.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43554.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha
CC family. {ECO:0000256|ARBA:ARBA00006734}.
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DR EMBL; AE017345; AAW43554.1; -; Genomic_DNA.
DR RefSeq; XP_570861.1; XM_570861.1.
DR AlphaFoldDB; Q5KGM3; -.
DR STRING; 214684.Q5KGM3; -.
DR PaxDb; 214684-Q5KGM3; -.
DR EnsemblFungi; AAW43554; AAW43554; CNE03110.
DR GeneID; 3257654; -.
DR KEGG; cne:CNE03110; -.
DR VEuPathDB; FungiDB:CNE03110; -.
DR eggNOG; KOG0530; Eukaryota.
DR HOGENOM; CLU_026582_1_1_1; -.
DR InParanoid; Q5KGM3; -.
DR OMA; HRHTIID; -.
DR OrthoDB; 20949at2759; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0005953; C:CAAX-protein geranylgeranyltransferase complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005965; C:protein farnesyltransferase complex; IBA:GO_Central.
DR GO; GO:0004662; F:CAAX-protein geranylgeranyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0004660; F:protein farnesyltransferase activity; IEA:EnsemblFungi.
DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 1.
DR InterPro; IPR002088; Prenyl_trans_a.
DR PANTHER; PTHR11129; PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR11129:SF1; PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA; 1.
DR Pfam; PF01239; PPTA; 5.
DR SUPFAM; SSF48439; Protein prenylyltransferase; 1.
DR PROSITE; PS51147; PFTA; 5.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Prenyltransferase {ECO:0000256|ARBA:ARBA00022602};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022602}.
SQ SEQUENCE 336 AA; 39558 MW; 50E7BBEAB6308AC2 CRC64;
MVTSTYIPMS QRQSWADIKP IIQDDGPNPV VPIMYSEEYK DAMDYFRAVA AKEEKSERAL
ELTEVIVRMN PAHYTVWQYR FSLLTSLNKS LEDELRLMNE FAVQNLKSYQ VWHHRLLLLD
RISPQDPVSE IEYIHESLLP DPKNYHTWAY LHWLYSHFSI LGRISEAQWE SELDWCNEML
RVDGRNNSAW GWRWYLRVSR PGAETSSHNL QDELIYILKS IHFIPHNVSA WNYLRGFLKH
FSLPLTPILP AILPYTASKP NTDMETVGTF HFPVPSDPLP EDTPLPVPLA LEYLADSFIE
QNRLDDAAEV FEKLSSKYDK MRAGYWEFRR RECVEE
//
