ID Q5KHF1_CRYNJ Unreviewed; 520 AA.
AC Q5KHF1; Q55T16;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 24-JAN-2024, entry version 126.
DE RecName: Full=TATA box binding protein associated factor (TAF) histone-like fold domain-containing protein {ECO:0000259|SMART:SM00803};
GN OrderedLocusNames=CNE00290 {ECO:0000313|EMBL:AAW43418.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43418.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43418.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF6 family.
CC {ECO:0000256|ARBA:ARBA00007688}.
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DR EMBL; AE017345; AAW43418.1; -; Genomic_DNA.
DR RefSeq; XP_570725.1; XM_570725.1.
DR AlphaFoldDB; Q5KHF1; -.
DR STRING; 214684.Q5KHF1; -.
DR PaxDb; 214684-Q5KHF1; -.
DR EnsemblFungi; AAW43418; AAW43418; CNE00290.
DR VEuPathDB; FungiDB:CNE00290; -.
DR eggNOG; KOG2549; Eukaryota.
DR HOGENOM; CLU_021711_3_2_1; -.
DR InParanoid; Q5KHF1; -.
DR OMA; YFVQFIA; -.
DR OrthoDB; 1529at2759; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IBA:GO_Central.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.25.40.770; TAF6, C-terminal HEAT repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR PANTHER; PTHR10221:SF9; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..72
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 154..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 55368 MW; 22CBACD3B879C566 CRC64;
MPAPQMMGIY PSESIQEVAQ SLPLDPLGPG AATLLAGDVE YRLHLILQEA KKFMVHAKRS
TLMPEDVEHA LEALNVEPIL IPPRPLALPS FHPLNLPPPA ANMPPQTIYT TTDDEIDFAS
YLKEPLPAGI ASSAGVKWKA HWLAVEGVQP AVPENPAPSS IHAGAGGGAQ RVKGAPAPAS
TTLKPSARAH LPQELQLYFT RLTTALVPPT ATLPESEPER HRLAALASLR NDVAVAGMLV
YVVKWLCESI QKCLMAPTAS IGHLVDAVGA LLANEGLFIE PYMHQLLPPL LSIILTVPLG
PHPPQPASSS QPSPTEIRSR ASDVLSKIAS TYSPSYPGLI PRLVSTLTKA LHSPPFPSPL
GAANPPTGRY EGAILGLGGL GPQAVRVGIW GEKGEGVKRI DELAGRLYSE AGKRKNPLVR
ATIKALAQII PPKPSNTPTP SLNVEQVTEM FGPNIAAGLS KKGWTASEMV RMREEELMRA
GSSDVSENER IGVDGERQLR EAGQGGEVED EKMEVDTPVV
//
