ID Q5KHI6_CRYNJ Unreviewed; 788 AA.
AC Q5KHI6; Q55UV0;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 08-NOV-2023, entry version 91.
DE RecName: Full=OPT family small oligopeptide transporter {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CND06360 {ECO:0000313|EMBL:AAW43244.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43244.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43244.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the oligopeptide OPT transporter family.
CC {ECO:0000256|ARBA:ARBA00008807}.
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DR EMBL; AE017344; AAW43244.2; -; Genomic_DNA.
DR RefSeq; XP_570551.1; XM_570551.1.
DR AlphaFoldDB; Q5KHI6; -.
DR PaxDb; 214684-Q5KHI6; -.
DR EnsemblFungi; AAW43244; AAW43244; CND06360.
DR VEuPathDB; FungiDB:CND06360; -.
DR eggNOG; KOG2262; Eukaryota.
DR HOGENOM; CLU_004965_3_2_1; -.
DR InParanoid; Q5KHI6; -.
DR OrthoDB; 1383663at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035673; F:oligopeptide transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR004648; Oligpept_transpt.
DR InterPro; IPR004813; OPT.
DR NCBIfam; TIGR00728; OPT_sfam; 1.
DR PANTHER; PTHR22601; ISP4 LIKE PROTEIN; 1.
DR PANTHER; PTHR22601:SF97; TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03140)-RELATED; 1.
DR Pfam; PF03169; OPT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Peptide transport {ECO:0000256|ARBA:ARBA00022856};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 101..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 597..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 89778 MW; 9DB519522127190B CRC64;
MFNSSRDNTT EQEKNDDEIY TTELKGDESP SSSSSDIDEK NEKFDPYVDQ SQEGIAVEEA
KLDDFIHRDE KYDWDSEEFR NIPELVRNTV SFEDDPSMPV ITFRAILLST IFCAIGSVIS
QISYFRTTTA QFPVFFVILA SHPLGKLLAR VLPDYTVPLG RFSFSLNPGP FSVKEHVIIG
IAANTGSQGQ WATYLPTNAA LYYNITMSPA IALFFGWGVS LLGFSFAAMV RPILIDDPQF
IFPLSMQQVA VYRSIQGTSE LHLERSRKQM RVFWWLFLGM FAWQFLPEFA FPFVASLAPL
CWFASRNHKV NFLGAGRGGA GLLNITLDWS NITSTVITYP YSVQVIIFVS FVIVCWILIP
IAYFGNLWGS PTWNIMSNGV FMKNGTSYPF NSLLDTDAQG FQVFNETRYE EIGLAYSGAQ
YLWNVFMWYA SYISSFVWCG LFLGPTIMHV FRAWRAKKPA HNDRLSRIAA KYPGLTWWEW
GLLTLIPFVI LLAVVVSKKL YMSTWTYFVA LGFGAAAMLP MSLVYAMSGY SMKVGIFNEL
IYGYMIEAKG SSRHPLGQLA YRIISGNVWY DARTVLEDQK IGHYFHLPPR QVIGIQILAN
MLALPINYAV MRWVLDTKFD YVSGKEVDPT GQWTGQEFQS YNSAGVQYSL VGPKRLFRSS
VYRPLTYGFV VGAAAPVIIW LLHKRFPRAR FNLWNTTIFF SGAATFYGNL STGPFTAFII
GTVWNFWLYR YRRKFWNMWA YISGAALDTG FNFNLLFIFI FLGTTGAVMP YWWGNNADSI
ERCFALNE
//
