ID Q5KHP4_CRYNJ Unreviewed; 1621 AA.
AC Q5KHP4; Q55UP7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 2.
DT 27-MAR-2024, entry version 121.
DE SubName: Full=MYO2-related {ECO:0000313|EMBL:AAW42813.2};
GN OrderedLocusNames=CND05780 {ECO:0000313|EMBL:AAW42813.2};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42813.2, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42813.2, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AE017344; AAW42813.2; -; Genomic_DNA.
DR RefSeq; XP_570120.1; XM_570120.1.
DR STRING; 214684.Q5KHP4; -.
DR PaxDb; 214684-Q5KHP4; -.
DR EnsemblFungi; AAW42813; AAW42813; CND05780.
DR VEuPathDB; FungiDB:CND05780; -.
DR eggNOG; KOG0160; Eukaryota.
DR HOGENOM; CLU_000192_9_0_1; -.
DR InParanoid; Q5KHP4; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd15480; fMyo2p_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR046943; Fungal_Myo2/2A_CBD.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140:SF860; DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C; 1.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 5.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149}.
FT DOMAIN 95..807
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1287..1570
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 685..707
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT COILED 980..1007
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 198..205
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1621 AA; 182925 MW; 1A07299FB1EA2BFC CRC64;
MTSLYSKGTL VWISQPSSGW VAGTVESLDL PTDGDSSSEV VMIVSHDSDP TTNETLKFPL
SALQSATTDP TSLRTTTSSL GQDYLPALRN PPALETAEDL ANLSNLNEPS VLHAMATRYM
QHYPYTYSGI VLLSMNPFTP LNIYETAFVK LYAGQKKGER EPHVFAIAEE ALDSMRRGDG
GGGVDPTGAG DQTIIVSGES GAGKTVAAKY ILKYFASAHH DSSTQSTVVG EDGMSEIEKQ
ILASNPIMEA FGNAKTTRND NSSRFGKYIE ILFNRTNEIT GARIRTYLLE RSRLTYQPIS
ERNYHIFYQL LAGAPSKERK DLSLSMAPRD FGYLAGGGPT STSIPGVDDS KEFAVTQSAL
STVGISIERQ WHIFRLLAAL LHLGNIKITQ IRTDAALADD DSALNIATDL LGIPLSDFKK
WIIKKQLTTR NEKIVTSLGS TQALVVRDSV AKFIYSSLFQ WLVCVVNDSL GGNNGGRSNA
TKFIGVLDIY GFEHFTKNSF EQFCINWANE KLQQEFYAHV FKLEQEEYVR EQISWKFIEF
ADNQACIDII EGKMGVLALL DEESRLPGGS DTSFATKLHQ QLVQPWQKQV FKKPRFQQGA
FTITHYAHEV TYDVEGFVEK NRDSVPEEHL SLLKSSANGF LCEVLAFALK PSEAPSQQNF
KTPLVMSKRV TPRKQTLGSM FKNSLTSLMD TINNTNVHYI RCIKPNEAKK AWELDSHQVL
SQLRACGVLE TIRISCNGYP SRWEYAQFAE RYHLMLHSKE WNQGLDLKQL CSLILQKTLD
NDDRYQLGLT KIFFRAGTLA FLESLRSRRQ YELATTIQKY IRRRLAYKHY SQLKSGAIVI
QNWWRGVLSR KKLVELKKLK VTLWIQSTAR GHLSRKRYIQ EKENVVRLQT VARRHLARKR
ANEMRELTAA VTLQCLFRSC AARREYQTQV RRIVVLQSQW RRKLAVRELV SLKIEAKSAT
KLKEISYQLE NKVVELTQAL QKRLSENKDL VSRVAALERE TAVLNQRNNE LLIGRQELEQ
RLSIALAESG NYKSLVAQKE QVESELRRKT DKDIEQREEI RLLTAQLDAA LCSTEETKAS
LDLANSQSVG DKATIDQLRT ELSHVREQLS RTNTLNALTK GNRSREVPSS PSTGQGFRHF
ENTIGLGTAP DQIPLARRRN RRHSMTAGSL LVGGGNQDAN QIVKLNPRAA STIYTQDISL
HLRDSQDLPF SPSLANTSDE ITRLLEDEVS LDDDVLQGLI YQLKIPNPSL HAPPTAKDVL
FPAHLISLVS NEMWKRHMRS ESERFLAVVM SAVQRHVVEF KGEDIIIPGI FWLSNIQEIL
SFISFAEDEE SKGYVPGYDF SNGHDSDWRG YIRLLGVVKH DLDSLEYNIY HTFMLEIKKK
LSKMVVPALI ESQSLPGFIT SEGSGVFSKM LGGIGGAQQP AAKMDDILNL LNKVWKCLKI
YYMEESVTHQ VMTELLKLIG QLSFNDLLMR RNFSSWKRAM QIQYNVTRIE EWCKAHDMPE
GLLQLEHLLQ ATKLLQLKKA TLNDIDILFD VCWILSPAQV QKLISQYHTA DYEAPLNAEI
LRAVAARVKP EDKNDQLLLA PETDDVGPYQ LPPPREIVNL ETYVPAWLNI PTVRRLAALV
A
//
