ID Q5KHV7_CRYNJ Unreviewed; 601 AA.
AC Q5KHV7;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Heat shock protein HSP60, putative {ECO:0000313|EMBL:AAW42752.1};
GN OrderedLocusNames=CND05160 {ECO:0000313|EMBL:AAW42752.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW42752.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW42752.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017344; AAW42752.1; -; Genomic_DNA.
DR RefSeq; XP_570059.1; XM_570059.1.
DR AlphaFoldDB; Q5KHV7; -.
DR STRING; 214684.Q5KHV7; -.
DR PaxDb; 214684-Q5KHV7; -.
DR EnsemblFungi; AAW42752; AAW42752; CND05160.
DR GeneID; 3257077; -.
DR KEGG; cne:CND05160; -.
DR VEuPathDB; FungiDB:CND05160; -.
DR eggNOG; KOG0101; Eukaryota.
DR HOGENOM; CLU_005965_0_3_1; -.
DR InParanoid; Q5KHV7; -.
DR OMA; DQVLMDH; -.
DR OrthoDB; 23943at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005844; C:polysome; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR GO; GO:0051083; P:'de novo' cotranslational protein folding; IBA:GO_Central.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0006450; P:regulation of translational fidelity; IBA:GO_Central.
DR CDD; cd10232; ScSsz1p_like_NBD; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR45639:SF32; HEAT SHOCK PROTEIN PDR13; 1.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR Pfam; PF00012; HSP70; 2.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Stress response {ECO:0000313|EMBL:AAW42752.1}.
FT REGION 521..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..546
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 63594 MW; 819C7FFF95E127B7 CRC64;
MSKPSVLGIN FGQSYASIAV IDKEGHPTCI ANEEGERQIA CAISYAGEQV YIGNGAMPHL
VKNGKNTIMG FRNLLGHTYD EVDHTAILTA PLIPSSTTPA YTVDILVPPP KAPSRSGVTS
SAVSGAATPA VAEPVPSKKT ISVPEVTSEF LSTLLTSATD FLGVKPSACV VSAPTWFTPE
QTEALRKAAE AADINVIQVL DEAAAVLVGY RVGLNEERKA RGLLGRPDEG NAGEEEARDK
RVVVLDMGET SLAVSVIQVA EGEYTVLAKA REDKLGGREF DNLLLKHFAK EFTKKTKVAL
DLPCGESASD ADKRAEAKLR LAVDHTKRSL SASSGAATCA VESLKEGMDL SSAINRLRFD
GLAAPVYRQV GSVLSNTVKS AGLDLCQIDE VLLAGASTLF PGLQSSLSYL FPGTTPITAA
IDPSQVIAIG CALQALHLTS LEDNLKLEDV LATAGPEGKA DVTAAPIGIV IPSQEANTLA
AVVVPSGAPL PVRRRVAIPA PAGKVALEIW EGKDEVKVDL VERPPAEKFE DDEEEDEEEE
EEEPEEVKTP ITVKTKALGA VEVELQKEGQ LVLEVIVQRG GGLEVRAWEE GREEAADKFE
A
//
