ID Q5KHX9_CRYNJ Unreviewed; 409 AA.
AC Q5KHX9; Q55UG5;
DT 15-FEB-2005, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Phosphatidylserine decarboxylase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=CND04930 {ECO:0000313|EMBL:AAW43172.1};
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684 {ECO:0000313|EMBL:AAW43172.1, ECO:0000313|Proteomes:UP000002149};
RN [1] {ECO:0000313|EMBL:AAW43172.1, ECO:0000313|Proteomes:UP000002149}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565 {ECO:0000313|Proteomes:UP000002149};
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J., Koo H.L., Krzywinski M.I., Kwon-Chung J.K.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
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DR EMBL; AE017344; AAW43172.1; -; Genomic_DNA.
DR RefSeq; XP_570479.1; XM_570479.1.
DR AlphaFoldDB; Q5KHX9; -.
DR STRING; 214684.Q5KHX9; -.
DR PaxDb; 214684-Q5KHX9; -.
DR EnsemblFungi; AAW43172; AAW43172; CND04930.
DR GeneID; 3256992; -.
DR KEGG; cne:CND04930; -.
DR VEuPathDB; FungiDB:CND04930; -.
DR eggNOG; KOG2419; Eukaryota.
DR HOGENOM; CLU_029061_2_1_1; -.
DR InParanoid; Q5KHX9; -.
DR OMA; ICSAADC; -.
DR OrthoDB; 1109500at2759; -.
DR Proteomes; UP000002149; Chromosome 4.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004609; F:phosphatidylserine decarboxylase activity; IEA:InterPro.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR003817; PS_Dcarbxylase.
DR PANTHER; PTHR10067; PHOSPHATIDYLSERINE DECARBOXYLASE; 1.
DR PANTHER; PTHR10067:SF17; PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2; 1.
DR Pfam; PF02666; PS_Dcarbxylase; 1.
PE 4: Predicted;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Pyruvate {ECO:0000256|ARBA:ARBA00023317};
KW Reference proteome {ECO:0000313|Proteomes:UP000002149};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 45754 MW; 021AC5DBF6C95072 CRC64;
MDPISDPSTQ ESPHPVQALP EELGKPLEDS LDHIVSNSKA VRGARKDQLA PSELRSDAVH
SHGPEAKHWI AKFFPSEETL DHLFAMEHMG NYVIDRMTGK KFFETMPIYV RVGMHLLFVS
GNSYMSYASV EKLLREKSIK QGQTYDQTGP DVEEHIRSFI RTYELPLDEL LVKDLSQYPT
FNSFFSRRLI ASARPITSVG DPTIIVSAAD CRLTVYQTVD QAKKFWIKGQ QFTLPNLLTG
KDVADMTFKA VQDDREAALS IHRLAPQDYH RFHSPVEGMI VAIKDIDGEL YTVNPQAINE
DLNVFTLNKR SIMLIHANLG SGRETVPIAF VAIGAMLVGS IGWSKKPGDK VCKGEELGWF
QYGGSTTITV FPKSAGVEFD KDLVENSKKQ LETFVRVGME IGKCSTEVK
//
